Zlatko Kopecki

Dr. Zlatko Kopecki

Future Industries Institute, University of South Australia, Mawson Lakes SA 5095, Australia
orcid

Research Focus & Metrics

Academic Career Length

21Years (2006-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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5 January 2021 in Antibiotics
Verified
Journal Article
Open access
PDF file
Hanif HaidariHanif Haidari
Hanif Haidari
Zlatko KopeckiZlatko Kopecki
Zlatko Kopecki
ASAdam T. Sutton
Adam T. Sutton
Sanjay GargSanjay Garg
Sanjay Garg
ACAllison Cowin
Allison Cowin
Krasimir VasilevKrasimir Vasilev
Krasimir Vasilev
Persistent wound infections have been a therapeutic challenge for a long time. Current treatment approaches are mostly based on the delivery of antibiotics, but these are not effective for all infections. Here, we report the development of a sensitive pH-responsive hydrogel that can provide controlled, pH-triggered release of silver nanoparticles (AgNPs). This delivery system was designed to sense the environmental pH and trigger the release of AgNPs when the pH changes from acidic to alkaline, as occurs due to the presence of pathogenic bacteria in the wound. Our results show that the prepared hydrogel restricts the release of AgNPs at acidic pH (pH = 4) but substantially amplifies it at alkaline pH (pH = 7.4 and pH = 10). This indicates the potential use of the hydrogel for the on-demand release of Ag+ depending on the environmental pH. In vitro antibacterial studies demonstrated effective elimination of both Gram-negative and positive bacteria. Additionally, the effective antibacterial dose of Ag+ showed no toxicity towards mammalian skin cells. Collectively, this pH-responsive hydrogel presents potential as a promising new material for the treatment of infected wounds.

25 August 2020 in ACS Applied Materials & Interfaces
Verified
Journal Article
Closed access
HHHanif Haidari
Hanif Haidari
Zlatko KopeckiZlatko Kopecki
Zlatko Kopecki
RBRichard Bright
Richard Bright
ACAllison Cowin
Allison Cowin
Sanjay GargSanjay Garg
Sanjay Garg
Krasimir VasilevKrasimir Vasilev
Krasimir Vasilev

1 July 2021 in Acta Biomaterialia
Verified
Journal Article
Closed access
Hanif HaidariHanif Haidari
Hanif Haidari
RBRichard Bright
Richard Bright
XSXanthe Strudwick
Xanthe Strudwick
Sanjay GargSanjay Garg
Sanjay Garg
Krasimir VasilevKrasimir Vasilev
Krasimir Vasilev
Zlatko KopeckiZlatko Kopecki
Zlatko Kopecki

10 November 2022 in ACS Applied Materials & Interfaces
Verified
Journal Article
Closed access
Hanif HaidariHanif Haidari
Hanif Haidari
Krasimir VasilevKrasimir Vasilev
Krasimir Vasilev
ACAllison Cowin
Allison Cowin
Zlatko KopeckiZlatko Kopecki
Zlatko Kopecki

22 December 2021 in ACS Applied Materials & Interfaces
Verified
Journal Article
Closed access
HHHanif Haidari
Hanif Haidari
RBRichard Bright
Richard Bright
Zlatko KopeckiZlatko Kopecki
Zlatko Kopecki
PZPeter S. Zilm
Peter S. Zilm
Sanjay GargSanjay Garg
Sanjay Garg
NGNirmal Goswami
Nirmal Goswami

1 August 2009 in Journal of Investigative Dermatology
Verified
Journal Article
Closed access
Zlatko KopeckiZlatko Kopecki
Zlatko Kopecki
RARuth Arkell
Ruth Arkell
BPBarry C. Powell
Barry C. Powell
ACAllison Cowin
Allison Cowin