Human adenoviruses (HAdV) are one of the most important pathogens detected in acute respiratory diseases in pediatrics and immunocompromised patients. In 1953, Wallace Rowe described it for the first time in oropharyngeal lymphatic tissue. To date, more than 110 types of HAdV have been described, with different cellular tropisms. They can cause respiratory and gastrointestinal symptoms, even urinary tract inflammation, although most infections are asymptomatic. However, there is a population at risk that can develop serious and even lethal conditions. These viruses have a double-stranded DNA genome, 25–48 kbp, 90 nm in diameter, without a mantle, are stable in the environment, and resistant to fat-soluble detergents. Currently the diagnosis is made with lateral flow immunochromatography or molecular biology through a polymerase chain reaction. This review aimed to highlight the HAdV variability and the pandemic potential that a HAdV3 and 7 recombinant could have considering the aggressive outbreaks produced in health facilities. Herein, we described the characteristics of HAdV, from the infection to treatment, vaccine development, and the evaluation of the social determinants of health associated with HAdV, suggesting the necessary measures for future sanitary control to prevent disasters such as the SARS-CoV-2 pandemic, with an emphasis on the use of recombinant AdV vaccines to control other potential pandemics.

Introduction: Tuberculosis (TB) is one of the most prevalent respiratory diseases in the world. In 2020 there were at least 9.9 million new infections, with 1.5 million deaths. Approximately 10% of people infected with Mycobacterium tuberculosis develop the disease during the first 2 to 5 years after infection. In South America, the diagnosis of Latent Tuberculosis Infections (LTBI) continues to be performed through the Mantoux tuberculin skin test (TST). Objective: The objective of our study was to compare the sensitivity of a new immunofluorescence IGRA test against a widely available IGRA kit on the market. Material and method: Close contact with infectious TB patients, HIV patients, or immunocompromised for another cause were recruited. Two interferon-gamma release assay (IGRA) diagnostic kits were used and compared with TST. Results: 76 patients were recruited, 93.42% were Chilean nationality, and 98.68% of the patients did not have immunosuppression. The sensitivity of the new technique was 88.89%, and the specificity was 92.50% in the study population compared to the IGRA previously used. In the subgroup older than 36 years, the sensitivity was 95.65%, and the specificity was 89.47%. Conclusion: IGRA techniques are a new resource in clinical laboratories to make an accurate diagnosis of LTBI in the region of the Americas. In our population, the greatest benefit of this new IGRA would be observed in people over 36 years of age, where the sensitivity of the technique was like that of the currently available test.

En la actualidad la obesidad es considerada como una pandemia, además de los cambios metabólicos ya sabidos, se producen alteraciones estructurales como las generadas en el sistema ventilatorio. Sin embargo, se ha observado que dependiendo de la forma de categorización de esta condición, puede o no existir alteración sobre este sistema generando así una complicación al momento de la elección de esta herramienta. Por lo tanto el objetivo de esta investigación fue comparar parámetros de la función pulmonar en individuos obesos (O) y normo-peso (Np) según índice de masa corporal (IMC) y porcentaje de grasa corporal (PGC). Se midió la función ventilatoria en 57 participantes, posteriormente estas variables se contrastaron entre los sujetos normo-peso (Np) y obesos (O) según IMC y PGC. Se observó un aumento significativo en el valor de la capacidad inspiratoria (CI) de O versus Np y del volumen de reserva espiratoria (VRE) y capacidad residual funcional (CRF) de Np en relación a O, tanto para la división por IMC como por PGC, en el grupo dividido por IMC las variables de resistencia especifica de las vías aéreas (sRaw) y presión inspiratoria máxima (PImáx) fueron significativamente mayor en los participantes O, asimismo, la conductancia específica de las vías aéreas (sGaw) fue significativamente mayor en sujetos Np. En conclusión, el IMC mostró mayor versatilidad como predictor de la función ventilatoria, sin embargo, se necesitan mayores estudios de los efectos mecánicos de este indicador y del PGC sobre las vías aéreas.