This systematic review and meta-analysis of randomized controlled trials tested the effects of home-based, supervised, or mixed exercise interventions on the functional capacity (FC) and quality of life (QoL) in colorectal cancer patients. A literature search was performed using the PubMed, Embase, Cochrane, and Medline databases. Two reviewers screened the literature through March 10, 2021 for studies related to exercise and colorectal cancer. Of the 1161 screened studies in the initial search, 13 studies met the eligibility criteria (home-based = 6 studies; supervised or mixed = 7 studies). Overall, 706 patients were enrolled in the trials, and 372 patients were submitted to home-based, supervised, or mixed exercise intervention. The overall results from the main meta-analysis showed a significant effect regarding supervised or mixed intervention (6 studies; p = 0.002; I² = 43%; PI 0.41–1.39); however, no significant effect was observed for home-based intervention (5 studies; p = 0.05; I² = 25%; PI − 0.34–0.76). A sensitivity analysis based on studies with intervention adherence ≥ 80% (home-based = 3 studies; supervised or mixed = 4 studies) revealed that home-based intervention or intervention entirely supervised or with some level of supervision (mixed) are effective in improving the QoL and FC of CRC patients. In summary, this meta-analysis verified that supervised and home-based exercise can modify QoL and FC when intervention adherence ≥ 80%. Regardless of the supervision characteristics, future RCTs are strongly encouraged to provide a detailed description of the exercise variables in physical interventions for CRC prescription. This perspective will allow a refined exercise prescription for patients with CRC, mainly according to their clinical status.

This narrative review explores the potential effects of Propolis and its bioactive compounds on bone health. Propolis, a resinous product collected by bees, is renowned for its antimicrobial, anti-inflammatory, and antioxidant properties. Recent research emphasizes its positive role in osteogenesis, primarily through the modulation of osteoclast and osteoblast activity via molecular pathways. Key mechanisms include reducing inflammatory cytokines, protecting against oxidative stress, and upregulating growth factor essential for bone formation. While compounds such as Caffeic Acid Phenethyl Ester, Apigenin, Quercetin, and Ferulic Acid have been well-documented, emerging evidence points to the significant roles of less-studied compounds like Pinocembrin, Kaempferol, p-Coumaric acid, and Galangin. This review synthesizes the current literature, focusing on the mechanisms by which these bioactive compounds influence osteogenesis. Firstly, it explores the techniques for characterizing bioactive compounds presented in propolis, the chemogeographic variations in its composition, and the effects of both crude extracts and isolated compounds on bone tissue, offering a comprehensive analysis of recent findings across different experimental models. Further, it discusses the effects of Propolis compounds on bone health. In summary, these compounds modulate signaling pathways, including nuclear factor kappa beta, wingless-related integration site, mitogen-activated protein kinase, vascular endothelial growth factor, and reactive oxygen species. These pathways influence the receptor activator of nuclear factor kappa-β/receptor activator of nuclear factor kappa-β ligand/osteoprotegerin system, fostering bone cell differentiation. This regulation mitigates excessive osteoclast formation, stimulates osteoblast activity, and ultimately contributes to the restoration of bone homeostasis by maintaining a balanced bone remodeling process.

In 1993, Uwe Tegtbur proposed a useful physiological protocol named the lactate minimum test (LMT). This test consists of three distinct phases. Firstly, subjects must perform high intensity efforts to induce hyperlactatemia (phase 1). Subsequently, 8 min of recovery are allowed for transposition of lactate from myocytes (for instance) to the bloodstream (phase 2). Right after the recovery, subjects are submitted to an incremental test until exhaustion (phase 3). The blood lactate concentration is expected to fall during the first stages of the incremental test and as the intensity increases in subsequent stages, to rise again forming a “U” shaped blood lactate kinetic. The minimum point of this curve, named the lactate minimum intensity (LMI), provides an estimation of the intensity that represents the balance between the appearance and clearance of arterial blood lactate, known as the maximal lactate steady state intensity (iMLSS). Furthermore, in addition to the iMLSS estimation, studies have also determined anaerobic parameters (e.g. peak, mean and minimum force/power) during phase 1 and also the maximum oxygen consumption in phase 3; therefore, the LMT is considered a robust physiological protocol. Although encouraging reports have been published in both human and animal models, there are still some controversies regarding three main factors: 1) the influence of methodological aspects on the LMT parameters; 2) LMT effectiveness for monitoring training effects; and 3) the LMI as a valid iMLSS estimator. Therefore, the aim of this review is to provide a balanced discussion between scientific evidence of the aforementioned issues, and insights for future investigations are suggested. In summary, further analyses in necessary to determine whether these factors are worthy, since the LMT is relevant in several contexts of health sciences.

Colorectal cancer (CRC) burden across the world is expected to increase by ~2.2 million new cases and ~1.1 million deaths by 2030. Regular physical exercise is recommended to prevent CRC, but the myriad of protocols preclude further discussion on how to manage its variables for this population. Home-based exercise guided by remote monitoring provides an alternative to surpass the barriers of supervised exercise. However, no meta-analysis was conducted to verify the effectiveness of this intervention for improving physical activity (PA). We performed a systematic review of remote and unsupervised strategies imposed on CRC patients for improving PA and compared, via a meta-analysis, their effectiveness against CRC patients submitted to usual care or no intervention. The databases PubMed, Scopus, and Web of Science were searched on 20 September 2022. Eleven studies attained the criteria for eligibility in the qualitative approach, and seven were included in the meta-analysis. No significant effect (p = 0.06) of remote and unsupervised exercise intervention was observed. However, a sensitivity analysis including three studies that only considered CRC patients was performed, demonstrating a significant effect in favor of exercise (p = 0.008). Based on our sensitivity analysis, remote and unsupervised exercise strategies were effective to improve the PA of CRC patients.

The aims of this study were to use a specific all-out 30-sec tethered test to determine the anaerobic parameters in elite kayakers and verify the relationship between these results and sports performance. Twelve elite slalom kayakers were evaluated. The tethered canoe system was created and used for the all-out 30-sec test application. Measurements of peak force, mean force, minimum force, fatigue index and impulse were performed. Performance evaluation was determined by measuring the time of race in a simulated race containing 24 gates on a white-water course. Blood was collected (25-µl) for analysis of lactate concentration at rest and at 2, 4, 6, 8 and 10-min intervals after both the all-out test and the simulated race. The Pearson product moment correlation shows a inverse and significant relationship of peak force, mean force and impulse with time of race. Blood lactate concentrations after the all-out test and the simulated race peak at same time (4 min). Additionally, no interaction was visualized between time and all-out test/simulated race for blood lactate concentrations (P <0.365). These results suggest a relationship between the parameters of the all-out test and performance. Thus, the tethered canoe system is a useful tool for determining parameters that could be used in training control of slalom kayakers.

Background: Among other aspects, aerobic fitness is indispensable for performance in slalom canoe.Purpose: To propose the maximal-lactate steady-state (MLSS) and critical-force (CF) tests using a tethered canoe system as new strategies for aerobic evaluation in elite slalom kayakers. In addition, the relationship between the aerobic parameters from these tests and the kayakers’ performances was studied.Methods: Twelve male elite slalom kayakers from the Brazilian national team participated in this study. All tests were conducted using a tethered canoe system to obtain the force records. The CF test was applied on 4 d and analyzed by hyperbolic (CF_hyper) and linear (CF_lin) mathematical models. The MLSS intensity (MLSS_int) was obtained by three 30-min continuous tests. The time of a simulated race was considered the performance index.Results: No difference (P < .05) between CF_hyper (65.9 ± 1.6 N) and MLSS_int (60.3 ± 2.5 N) was observed; however, CF_lin (71.1 ± 1.7 N) was higher than MLSS_int. An inverse and significant correlation was obtained between MLSS_int and performance (r = –.67, P < .05).Conclusion: In summary, MLSS and CF tests on a tethered canoe system may be used for aerobic assessment of elite slalom kayakers. In addition, CF_hyper may be used as an alternative low-cost and noninvasive method to estimate MLSS_int, which is related with slalom kayakers’ performance.