Katarzyna Paradowska

Dr. Katarzyna Paradowska

Department of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland
orcid

Research Focus & Metrics

Academic Career Length

19Years (2008-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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11 January 2023 in Life
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Journal Article
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JGJulia Magdalena Górnicka
Julia Magdalena Górnicka
MMMartyna Mika
Martyna Mika
Oliwia WróblewskaOliwia Wróblewska
Oliwia Wróblewska
Paweł SiudemPaweł Siudem
Paweł Siudem
Katarzyna ParadowskaKatarzyna Paradowska
Katarzyna Paradowska
Turmeric is a strong-taste component of spices characteristic of Indian cuisine. It is obtained from the turmeric rhizome (Curcumae longae rhizoma) and has been used for thousands of years not only for culinary purposes, but also for medicinal purposes. It contains a group of organic compounds called curcuminoids. Curcumin is the main representative of this group of compounds which is also most frequently studied. In recent years, bioactive curcuminoids (including curcumin in the first place) have become more and more popular due to a wide spectrum of their biological activity. The anticancer, antibacterial, anti-inflammatory, and antiaging effects of curcumin have been confirmed by numerous in vitro and in vivo studies, as well as in clinical trials. However, an obstacle to simple, clinical application of curcumin is its poor bioavailability (which is due to its hydrophobic nature) and its very weak water solubility. Therefore, many scientists are working on improving the solubility of curcumin in water, which is the topic of the present article. Attempts have been made to combine curcumin with nanoparticles (polysaccharide or silica). Nanosuspensions or complexes with cyclodextrins are also considered. A promising direction is the search for new polymorphic varieties as well as obtaining cocrystals with curcumin which are characterized by better water solubility.

28 December 2022 in Molecules
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NDNatalia Dobros
Natalia Dobros
KZKatarzyna Dorota Zawada
Katarzyna Dorota Zawada
Katarzyna ParadowskaKatarzyna Paradowska
Katarzyna Paradowska
Lavender is a valuable medicinal plant belonging to the Lamiaceae family. Currently 39 species are known, but only Lavandula angustifolia is a pharmacopoeial raw material. Lavender has a long history of medicinal use and mainly exhibits antioxidant, anti-inflammatory, sedative, antidepressant, spasmolytic, anticholinesterases, antifungal and antibacterial properties. Used internally, it relieves symptoms of mental stress and insomnia and supports digestion. Topical use of lavender in aromatherapy, neuralgia and antiseptics is also known. The constant interest in lavender, and in particular in Lavandula angustifolia, in the field of medicine and pharmacy is evidenced by the growing number of publications. In view of so many studies, it seems important to review traditional and modern extraction techniques that determine the chemical composition responsible for the antioxidant and anti-inflammatory effects of various extracts from the species of the Lavandula genus.

5 April 2022 in Antioxidants
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NDNatalia Dobros
Natalia Dobros
KZKatarzyna Dorota Zawada
Katarzyna Dorota Zawada
Katarzyna ParadowskaKatarzyna Paradowska
Katarzyna Paradowska
Lavender is a valuable perennial plant from the Lamiaceae family. It is grown mainly for its essential oil, but it also contains polar bioactive compounds such as polyphenols and coumarins. Their level depends on the species, cultivars, geographical origin, climatic conditions, harvest time and extraction method. The authors investigated the effect of several extraction procedures (maceration, decoction and ultrasound-assisted extraction) applied to three cultivars of Lavandula angustifolia (Betty’s Blue, Elizabeth, Hidcote) and two cultivars of Lavandula x intermedia (Grosso, Gros Bleu) on the yield of the polyphenolic compounds and antioxidant activity. HPLC analysis showed the presence of rosmarinic acid (2.52–10.82 mg/g), ferulic acid glucoside (2.94–8.67 mg/g), caffeic acid (1.70–3.10 mg/g), morin (1.02–13.63 mg/g), coumarin (1.01–5.97 mg/g) and herniarin (1.05–8.02 mg/g). The content of phenolic acids and flavonoids was higher in lavender, while the content of coumarins was higher in lavandin in all types of extracts. The antioxidant activity was determined by DPPH-EPR assay for antiradical properties (104.58–206.77 μmol Trolox/g) and FRAP assay for reducing properties (79.21–203.06 μmol Trolox/g). The obtained results showed that the cultivar is the dominant factor differentiating the samples. Still, the extraction method plays an important role in the final bioactive substances content and antioxidant properties of obtained extracts.

24 May 2013 in Journal of the Science of Food and Agriculture
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MJMarta K Jamróz
Marta K Jamróz
Katarzyna ParadowskaKatarzyna Paradowska
Katarzyna Paradowska
KZKatarzyna Dorota Zawada
Katarzyna Dorota Zawada
KMKaterina Makarova
Katerina Makarova
SKSławomir Kaźmierski
Sławomir Kaźmierski
IWIwona Wawer
Iwona Wawer

15 July 2020 in Molecules
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AMAgnieszka Majewska
Agnieszka Majewska
Paweł SiudemPaweł Siudem
Paweł Siudem
Katarzyna ParadowskaKatarzyna Paradowska
Katarzyna Paradowska
MGMałgorzata Gralec
Małgorzata Gralec
SKSławomir Kaźmierski
Sławomir Kaźmierski
IWIwona Wawer
Iwona Wawer
Aronia melanocarpa (Michx.) Elliott’s (chokeberry) besides anthocyanins contains significant amounts of hydroxycinnamic acids: Chlorogenic and its isomer neochlorogenic acid. They exhibit antioxidant, anti-inflammatory, antidiabetic, and antibacterial activities, thus they can have a significant impact on the health-promoting properties of Aronia. The aim of our research was to determine the changes in the content of chlorogenic acids (CGAs) and anthocyanins during fruit development and ripening, with a particular emphasis on acids. Aronia fruit samples were collected from July to October on two organic farms in Poland. The chemical composition of the extracts was determined by NMR spectroscopy and HPLC-DAD. 1H-NMR and HPLC data were analyzed using chemometric analysis and multivariate statistics (PCA). The results showed that the content of chlorogenic acids and anthocyanins changes during ripening and depends on the time of harvest and the region of cultivation. A correlation between the time of CGAs reduction and the appearance of anthocyanins was also noticed. The result of our research was also a database in the form of NMR parameters, which allows analysis of the metabolite profile and tracking of its changes. The 1H-NMR spectrum showing anthocyanin and CGA resonance can be considered the Aronia berry fingerprint.

1 February 2019 in Journal of Molecular Structure
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Journal Article
Closed access
Paweł SiudemPaweł Siudem
Paweł Siudem
IWIwona Wawer
Iwona Wawer
Katarzyna ParadowskaKatarzyna Paradowska
Katarzyna Paradowska