The technique of Levenberg–Marquardt back propagation with neural networks (TLMB-NN) was used in this research article to investigate the heat transfer of Maxwell base fluid flow of nanomaterials (HTM-BFN) with MHD over vertical moving surfaces. In this study, the effects of thermal energy, concentration, and Brownian motion are also employed. Moreover, the impacts of a heat-absorbing fluid with viscous dissipation and radiation have been explored. To simplify the governing equations from a stiff to a simple system of non-linear ODEs, we exploited the efficacy of suitable similarity transformation mechanism. Through applicability of state-of-the-art Adams numerical technique, a set of data for suggested (TLMB-NN) is generated for several situations (scenarios) by changing parameters, such as the Thermophoresis factor N_t, Hartmann number M, Eckert number E_c, concentration Grashoff parameter G_c, Prandtl number P_r, Lewis number Le, thermal Grashof number G_T, and Brownian motion factor N_b. The estimate solution of different instances has validated using the (TLMB-NN) training, testing, and validation method, and the recommended model was compared for excellence. Following that, regression analysis, mean square error, and histogram explorations are used to validate the suggested (TLMB-NN). The proposed technique is distinguished based on the proximity of the proposed and reference findings, with an accuracy level ranging from 10⁻⁹ to 10⁻¹⁰.