Sleep is a period of rest that is essential for functional learning ability, mental health, and even the performance of normal activities. Insomnia, sleep apnea, and restless legs are all examples of sleep-related issues that are growing more widespread. When appropriately analyzed, the recording of bio-electric signals, such as the Electroencephalogram, can tell how well we sleep. Improved analyses are possible due to recent improvements in machine learning and feature extraction, and they are commonly referred to as automatic sleep analysis to distinguish them from sleep data analysis by a human sleep expert. This study outlines a Systematic Literature Review and the results it provided to assess the present state-of-the-art in automatic analysis of sleep data. A search string was organized according to the PICO (Population, Intervention, Comparison, and Outcome) strategy in order to determine what machine learning and feature extraction approaches are used to generate an Automatic Sleep Scoring System. The American Academy of Sleep Medicine and Rechtschaffen & Kales are the two main scoring standards used in contemporary research, according to the report. Other types of sensors, such as Electrooculography, are employed in addition to Electroencephalography to automatically score sleep. Furthermore, the existing research on parameter tuning for machine learning models that was examined proved to be incomplete. Based on our findings, different sleep scoring standards, as well as numerous feature extraction and machine learning algorithms with parameter tuning, have a high potential for developing a reliable and robust automatic sleep scoring system for supporting physicians. In the context of the sleep scoring problem, there are evident gaps that need to be investigated in terms of automatic feature engineering techniques and parameter tuning in machine learning algorithms.

This paper presents a novel EEG-based learning system designed to enhance the efficiency and effectiveness of studying by dynamically adjusting the difficulty level of learning materials based on real-time attention levels. In the training phase, EEG signals corresponding to high and low concentration levels are recorded while participants engage in quizzes to learn and memorize Chinese characters. The attention levels are determined based on performance metrics derived from the quiz results. Following extensive preprocessing, the EEG data undergoes several feature extraction steps: removal of artifacts due to eye blinks and facial movements, segregation of waves based on their frequencies, similarity indexing with respect to delay, binary thresholding, and (PCA). These extracted features are then fed into a k-NN classifier, which accurately distinguishes between high and low attention brain wave patterns, with the labels derived from the quiz performance indicating high or low attention. During the implementation phase, the system continuously monitors the user’s EEG signals while studying. When low attention levels are detected, the system increases the repetition frequency and reduces the difficulty of the flashcards to refocus the user’s attention. Conversely, when high concentration levels are identified, the system escalates the difficulty level of the flashcards to maximize the learning challenge. This adaptive approach ensures a more effective learning experience by maintaining optimal cognitive engagement, resulting in improved learning rates, reduced stress, and increased overall learning efficiency. Our results indicate that this EEG-based adaptive learning system holds significant potential for personalized education, fostering better retention and understanding of Chinese characters.

An increasing problem in today’s society is the spiraling number of people suffering from various sleep disorders. The research results presented in this paper support the use of a novel method that employs techniques from the classification of sleep disorders for more accurate scoring. Applying this novel method will assist researchers with better analyzing subject profiles for recommending prescriptions or to alleviate sleep disorders. In biomedical research, the use of animal models is required to experimentally test the safety and efficacy of a drug in the pre-clinical stage. We have developed a novel LSTM Recurrent Neural Network to process Pharmaco-EEG Profiles of rats to automatically score their sleep–wake stages. The results indicate improvements over the current methods; for the case of combined channels, the model accuracy improved by 1% and 3% in binary or multiclass classifications, respectively, to accuracies of 93% and 82%. In the case of using a single channel, binary and multiclass LSTM models for identifying rodent sleep stages using single or multiple electrode positions for binary or multiclass problems have not been evaluated in prior literature. The results reveal that single or combined channels, and binary or multiclass classification tasks, can be applied in the automatic sleep scoring of rodents.

Malware is malicious software that compromises data and computer systems. In 2024, the Internet Crime Complaint Center (IC3) reported $12.47 million in ransomware losses alone, highlighting the escalating severity of cyber threats. Because source code is rarely available, analysts rely on disassembling malware binaries to understand their internal behavior, examining control flow, functions, and embedded routines. To evade detection, malware authors use obfuscation techniques such as packing, which compresses or encrypts executables and restores them at runtime via a decryption stub. Since executables contain both code and data sections, unpacking often produces disassembly with irrelevant functions originating from data regions and decryption routines. These extraneous functions introduce noise and can mislead analysis. In malware lineage studies, similarity scores between versions are used to infer evolutionary relationships; noise functions can distort these scores, resulting in inaccurate lineage graphs and flawed conclusions. We propose a technique to identify noise functions in malware disassembly recovered after unpacking. Our method was evaluated on 13 open-source Windows programs and further tested on executables packed with 12 general-purpose packers. Two machine learning models Support Vector Machine (SVM) and K-Nearest Neighbor (K-NN) were employed for classification. SVM achieved 97.36% accuracy on clean data and 92.76% on packed executables, demonstrating strong generalization. By effectively eliminating disassembly noise, our approach enhances the precision of binary diffing, malware detection, and lineage reconstruction, offering a practical advancement for real-world malware analysis.

Emerging diseases like Parkinson or Alzheimer's, which are not curable, endanger human mental health and are challenging to research. Drug target interactions (DTI) are pivotal in the screening of candidate drugs and focus on a small pool of drug targets. Electroencephalogram shows the responses to psychotropic medicines in the brain bioelectric activity. Synaptic activity can be analyzed by using Local Field Potential recordings obtained from micro-electrodes implanted in the brain. The aim is to evaluate the effects of drug on brain bioelectric activity and increase the drug classification accuracy. The ultimate goal is to advance our understanding of how drugs affect synaptic activity and open the door to more focused treatment for neurodegenerative diseases. In this study, Pharmaco-EEG recordings are processed using Advanced neural network models, particularly Convolutional Neural Networks, to assess the effects of medications. The five different medicines used in this study are Ephedrine, Fluoxetine, Kratom, Morphine, and Saline. The signals observed are local field potential signals. To overcome some limits of DTI prediction, we propose Bidirectional Long Short-Term Memory (LSTM) for the categorization of intracranial EEG (i-EEG) data, departing from standard approaches. Similar EEG patterns are presumably caused by drugs that work by homologous pharmacological pathways, producing similar psychotropic effects. To improve accuracy and reduce training loss, our study introduces a bidirectional LSTM model for classification along with Bayesian optimization High recall, precision, and F1-Scores, particularly a 95% F1-Score for morphine, ephedrine, fluoxetine, and saline, suggest good performance in predicting these drug classes. Kratom produces a somewhat lower recall of 94%, but a high F1-Score of 97% and perfect precision of 1.00. The weighted average F1-Score, macro average, and overall accuracy are all consistently high (around 97%), indicating that the model works well throughout the spectrum of drugs. Improved model performance was demonstrated by using a diversified dataset with five drug categories and bidirectional LSTM boosted with Bayesian optimization for hyperparameter tuning. From earlier limited-category models, it represents a substantial advancement.