This article describes the configuration and technical specifications of a multi-rotor unmanned aerial vehicle (UAV) using a red–green–blue (RGB) sensor for the acquisition of images needed for the production of orthomosaics to be used in archaeological applications. Several flight missions were programmed as follows: flight altitudes at 30, 40, 50, 60, 70 and 80 m above ground level; two forward and side overlap settings (80%–50% and 70%–40%); and the use, or lack thereof, of ground control points. These settings were chosen to analyze their influence on the spatial quality of orthomosaicked images processed by Inpho UASMaster (Trimble, CA, USA). Changes in illumination over the study area, its impact on flight duration, and how it relates to these settings is also considered. The combined effect of these parameters on spatial quality is presented as well, defining a ratio between ground sample distance of UAV images and expected root mean square of a UAV orthomosaick. The results indicate that a balance between all the proposed parameters is useful for optimizing mission planning and image processing, altitude above ground level (AGL) being main parameter because of its influence on root mean square error (RMSE).