This paper proposes an imputation method for missing data based on an extreme learning machine auto-encoder (ELM-AE). The imputation chooses a set of plausible values determined by ELM-AE and then substitutes the average of these plausible values for the missing values. To compare the performance of ELM-AE imputation with the three other widely used imputation techniques, we conducted comprehensive experiments using seven UCI benchmark data sets. The proposed ELM-AE imputation approach proved to be superior to the other three methods based on the results using these data sets.

The gene expression profile has the characteristics of a high dimension, low sample, and continuous type, and it is a great challenge to use gene expression profile data for the classification of tumor samples. This paper proposes a cross-entropy based multi-filter ensemble (CEMFE) method for microarray data classification. Firstly, multiple filters are used to select the microarray data in order to obtain a plurality of the pre-selected feature subsets with a different classification ability. The top N genes with the highest rank of each subset are integrated so as to form a new data set. Secondly, the cross-entropy algorithm is used to remove the redundant data in the data set. Finally, the wrapper method, which is based on forward feature selection, is used to select the best feature subset. The experimental results show that the proposed method is more efficient than other gene selection methods and that it can achieve a higher classification accuracy under fewer characteristic genes.