Andreas Müssigbrodt

Dr. Andreas Müssigbrodt

Department of Cardiology, University Hospital Centre of Martinique-CHU Martinique, 97200 Martinique, France
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Research Focus & Metrics

Academic Career Length

26Years (2001-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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26 October 2001 in Journal of Medicinal Chemistry
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Journal Article
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EDElisabeth Davioud-Charvet
Elisabeth Davioud-Charvet
SDSandrine Delarue
Sandrine Delarue
CBChristophe Biot
Christophe Biot
BSBabett Schwöbel
Babett Schwöbel
CBCatharina C. Boehme
Catharina C. Boehme
KBKatja Becker
Katja Becker

31 October 2018 in The International Journal of Cardiovascular Imaging
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Journal Article
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CCCsilla Czimbalmos
Csilla Czimbalmos
ICIbolya Csecs
Ibolya Csecs
ZDZsofia Dohy
Zsofia Dohy
ATAttila Toth
Attila Toth
FSFerenc Imre Suhai
Ferenc Imre Suhai
VHVágó Hajnalka
Vágó Hajnalka
Both, arrhythmogenic right ventricular cardiomyopathy (ARVC) and regular training are associated with right ventricular (RV) remodelling. Cardiac magnetic resonance (CMR) is given an important role in the diagnosis of ARVC in current task force criteria (TFC), however, they contain no cut-off values for athletes. We aimed to confirm the added value of feature tracking and to provide new cut-off values to differentiate between ARVC and athlete’s heart. Healthy athletes with training of minimal 15 h/week (n = 34), patients with definite ARVC (n = 34) and highly trained athletes with ARVC (n = 8) were examined by CMR. Left and right ventricular volumes and masses were determined. Global right and left ventricular, and regional strain analysis for the RV free wall was performed using feature tracking on balanced steady-state free precession cine images. 94% of healthy athletes showed RV dilatation of the proposed TFC, 14.7% showed RV ejection fraction (RVEF) between 45–50%, none of them had RVEF < 45%. Although RVEF showed the highest accuracy in differentiating between athlete’s heart and ARVC, only 37.5% of athletes with ARVC showed RVEF < 45%. The only parameters falling in the pathological range (based on our established cut-off values: > − 25.6 and > − 1.4, respectively) in all athletes with ARVC were the strain and strain rate of the midventricular RV free wall. Establishing RVEF and RV strain analysis provides an important tool to distinguish ARVC from athlete’s heart. CMR based regional strain and strain rate values may help to identify ARVC even in highly trained athletes with preserved RVEF.

30 November 2016 in Journal of Interventional Cardiac Electrophysiology
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Andreas MüssigbrodtAndreas Müssigbrodt
Andreas Müssigbrodt
EEElena Efimova
Elena Efimova
HKHelge Knopp
Helge Knopp
LBLivio Bertagnolli
Livio Bertagnolli
NDNikolaos Dagres
Nikolaos Dagres
AAArash Arya
Arash Arya

29 January 2015 in BioMed Research International
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Andreas MüssigbrodtAndreas Müssigbrodt
Andreas Müssigbrodt
MGMatthias Grothoff
Matthias Grothoff
BDBorislav Dinov
Borislav Dinov
JKJedrzej Kosiuk
Jedrzej Kosiuk
SRSergio Richter
Sergio Richter
GHGerhard Hindricks
Gerhard Hindricks
Radiofrequency (RF) ablation with irrigated tip catheters decreases the likelihood of thrombus and char formation and enables the creation of larger lesions. Due to the potential dramatic consequences, the prevention of thromboembolic events is of particular importance for left-sided procedures. Although acute success rates of ventricular tachycardia (VT) ablation are satisfactory, recurrence rate is high. Apart from the progress of the underlying disease, reconduction and the lack of effective transmural lesions play a major role for VT recurrences. This paper reviews principles of lesion formation with radiofrequency and the effect of tip irrigation as well as recent advances in new technology. Potential areas of further development of catheter technology might be the improvement of mapping by better substrate definition and resolution, the introduction of bipolar and multipolar ablation techniques into clinical routine, and the use of alternative sources of energy.

7 June 2015 in EP Europace
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Andreas MüssigbrodtAndreas Müssigbrodt
Andreas Müssigbrodt
SJSilke John
Silke John
JKJedrzej Kosiuk
Jedrzej Kosiuk
SRSergio Richter
Sergio Richter
GHGerhard Hindricks
Gerhard Hindricks
ABAndreas Bollmann
Andreas Bollmann
Electrical cardioversion is one cornerstone for the rhythm control strategy of atrial fibrillation (AF), which is, however, hampered by immediate AF recurrence (IRAF) or failed electrical cardioversion (FECV). We aimed to investigate the potential role of vernakalant for facilitated electrical cardioversion in cardioversion-resistant AF. The subjects of this study were 63 patients referred to the Heart Centre Leipzig between November 2011 and May 2014 for transthoracic electrical cardioversion of AF. All patients experienced after antiarrhythmic-naïve electrical cardioversion either IRAF (n = 44; 70%) or FECV (n = 19; 30%). After drug infusion, electrical cardioversion was successful in 66.7% of vernakalant-treated as opposed to 46.7% of amiodarone-treated patients (P = 0.109). Multivariate analysis revealed treatment with vernakalant (OR 0.057, 95% CI 0.006–0.540, P = 0.013), treatment with ACEI or ARB (OR 0.101, 95% CI 0.015–0.691 P = 0.019), and IRAF after initial CV (OR 0.047, 95% CI 0.004–0.498, P = 0.011) as predictors for successful, drug-facilitated electrical cardioversion. Subgroup analysis of 18 patients with previous AF ablation revealed a significantly higher success rate of electrical cardioversion after infusion of vernakalant than after infusion of amiodarone (66.7 vs. 11.1%, P = 0.016). Vernakalant may therefore be considered as a useful agent for facilitated electrical cardioversion in cardioversion-resistant AF.

1 July 2018 in International Journal of Cardiology
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Journal Article
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MDMichael Döring
Michael Döring
MEMicaela Ebert
Micaela Ebert
NDNikolaos Dagres
Nikolaos Dagres
Andreas MüssigbrodtAndreas Müssigbrodt
Andreas Müssigbrodt
KBKerstin Bode
Kerstin Bode
SRSergio Richter
Sergio Richter