A highly-wearable single–channel instrument, conceived with off-the-shelf components and dry electrodes, is proposed for detecting human stress in real time by electroencephalography (EEG). The instrument exploits EEG robustness to movement artifacts with respect to other biosignals for stress assessment. The single-channel differential measurement aims at analyzing the frontal asymmetry, a well-claimed EEG feature for stress assessment. The instrument was characterized metrologically on human subjects. As triple metrological references, standardized stress tests, observational questionnaires given by psychologists, and performance measurements were exploited. Four standard machine learning classifiers (SVM, k-NN, Random Forest, and ANN), trained on 50% of the data set, reached more than 90% accuracy in classifying each 2-s epoch of EEG acquired from stressed subjects.

An instrument for remote control of robot by wearable Brain Computer Interface is proposed for rehabilitating children with attention deficit/hyperactivity disorder (ADHD). Augmented Reality (AR) glasses generate flickering stimuli and a single-channel electroencephalographic Brain Computer Interface detect the elicited Steady State Visual Evoked Potentials (SSVEP). This allows to benefit from the SSVEP robustness by leaving available the view of robot movements. Together with the lack of training, a single channel maximizes the device’s wearability, fundamental for the acceptance by ADHD children. Effectively controlling the movements of a robot through a new channel enhances rehabilitation engagement and effectiveness. A case study at an accredited rehabilitation center on 10 healthy adult subjects highlighted an average accuracy higher than 83%, with Information Transfer Rate (ITR) up to 39 bits per minute. Preliminary further tests on 4 ADHD patients between 6 and 8 years old provided highly positive feedback on device acceptance and attentional performance.

The market uptake of Brain-Computer Interface technologies for clinical and non-clinical applications is attracting the scientific world towards the development of daily-life wearable systems. Beyond the use of dry electrodes and wireless technology, reducing the number of channels is crucial to enhance the ergonomics of devices. This paper presents a review of the studies exploiting a number of channels less than 16 for electroencephalographic (EEG) based-emotion recognition. The main findings of this review concern: (i) the criteria to select the most promising scalp areas for EEG acquisitions; (ii) the attention to prior neurophysiological knowledge; and (iii) the convergences among different studies with respect to preferable areas of the scalp for signal acquisition. Three main approaches emerge for channel selection: data-driven, prior knowledge-based, and based on commercially-available wearable solutions. The most spread is the data-driven, but the neurophysiology of emotions is rarely taken into account. Furthermore, commercial EEG devices usually do not provide electrodes purposefully chosen to assess emotions. Considerable convergences emerge for some electrodes: Fp1, Fp2, F3 and F4 resulted the most informative channels for the valence dimension, according to both data-driven and neurophysiological prior knowledge approaches. The P3 and P4 resulted in being significant for the arousal dimension.

A systematic review on electroencephalographic (EEG)-based feature extraction strategies to diagnosis and therapy of attention deficit hyperactivity disorder (ADHD) in children is presented. The analysis is realized at an executive function level to improve the research of neurocorrelates of heterogeneous disorders such as ADHD. The Quality Assessment Tool for Quantitative Studies (QATQS) and field-weighted citation impact metric (Scopus) were used to assess the methodological rigor of the studies and their impact on the scientific community, respectively. One hundred and one articles, concerning the diagnostics and therapy of ADHD children aged from 8 to 14, were collected. Event-related potential components were mainly exploited for executive functions related to the cluster inhibition, whereas band power spectral density is the most considered EEG feature for executive functions related to the cluster working memory. This review identifies the most used (also by rigorous and relevant articles) EEG signal processing strategies for executive function assessment in ADHD.

Wearable electroencephalography (EEG) enables brain monitoring in real-world environments beyond clinical settings; however, the relaxed constraints of the acquisition setup often compromise signal quality. This review examines methods for artifact detection and for the identification of artifact categories (e.g., ocular) and specific sources (e.g., eye blink) in wearable EEG. A systematic search was conducted across six databases using the query: (“electroencephalographic” OR “electroencephalography” OR “EEG”) AND (“Artifact detection” OR “Artifact identification” OR “Artifact removal” OR “Artifact rejection”) AND “wearable”. Following PRISMA guidelines, 58 studies were included. Artifacts in wearable EEG exhibit specific features due to dry electrodes, reduced scalp coverage, and subject mobility, yet only a few studies explicitly address these peculiarities. Most pipelines integrate detection and removal phases but rarely separate their impact on performance metrics, mainly accuracy (71%) when the clean signal is the reference and selectivity (63%), assessed with respect to physiological signal. Wavelet transforms and ICA, often using thresholding as a decision rule, are among the most frequently used techniques for managing ocular and muscular artifacts. ASR-based pipelines are widely applied for ocular, movement, and instrumental artifacts. Deep learning approaches are emerging, especially for muscular and motion artifacts, with promising applications in real-time settings. Auxiliary sensors (e.g., IMUs) are still underutilized despite their potential in enhancing artifact detection under ecological conditions. Only two studies addressed artifact category identification. A mapping of validated pipelines per artifact type and a survey of public datasets are provided to support benchmarking and reproducibility.

An on-chip transducer, for monitoring noninvasively the insulin bio-availability in real time after administration in clinical diabetology, is proposed. The bioavailability is assessed as insulin decrease in situ after administration by means of local impedance measurement. Inter-and-intra individual reproducibility is enhanced by a personalized model, specific for the subject, identified and validated during each insulin administration. Such a real-time noninvasive bioavailability measurement allows to increase the accuracy of insulin bolus administration, by attenuating drawbacks of glycemic swings significantly. In the first part of this paper, the concept, the architecture, and the operation of the transducer, as well as details about its prototype, are illustrated. Then, the metrological characterization and validation are reported in laboratory, in vitro on eggplants, ex vivo on pig abdominal non-perfused muscle, and in vivo on a human subject, using injection as a reference subcutaneous delivery of insulin. Results of significant intra-individual reproducibility in vitro and ex vivo point out noteworthy scenarios for assessing insulin bioavailability in clinical diabetology.