Both chemical corrosion and axial compression impose critical influences on the internal microstructure of rock. Meanwhile, chemical corrosion can change a rock’s mineral composition, which in turn affects the physical and mechanical properties of the rock. To investigate the dynamic strength characteristics of white sandstone under the coupling effect of axial load and chemical corrosion, a dynamic and static combined loading test device was adopted for performing cyclic impact tests on white sandstone immersed in chemical solution. The results show that with the increasing number of cycles under the same load, the peak strength of the rock presented a trend of ‘strengthening first and then weakening’. The strength of rock resistance to impact failure reached its maximum when the solution of pH was 7 and axial pressure was 12.6 MPa. Under the same axial pressure, the effect of solution pH on the initial dynamic strength of white sandstone is a normal distribution. Acidic and alkaline environments are harmful to rocks during the initial impact, while neutral environments exert little effect and the pH of the solution influences the particle size of impact crushing particles. In addition, the chemical solution has a significant effect on the deterioration of rock strength during the process of initial impact, and the effect is inconspicuous in the later period.