Piero Borga

Dr. Piero Borga

orcid

Research Focus & Metrics

Academic Career Length

5Years (2022-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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15 January 2022 in Biosensors and Bioelectronics
Verified
Journal Article
Closed access
PPPaola Piedimonte
Paola Piedimonte
Laura SolaLaura Sola
Laura Sola
Marina CretichMarina Cretich
Marina Cretich
AGAlessandro Gori
Alessandro Gori
MCMarcella Chiari
Marcella Chiari
MSMarco Sampietro
Marco Sampietro

25 April 2022 in Sensors
Verified
Journal Article
Open access
PDF file
PBPiero Borga
Piero Borga
FMFrancesca Milesi
Francesca Milesi
NPNicola Peserico
Nicola Peserico
CGChiara Groppi
Chiara Groppi
Francesco DaminFrancesco Damin
Francesco Damin
Riccardo BertaccoRiccardo Bertacco
Riccardo Bertacco
Integrated optical biosensors are gaining increasing attention for their exploitation in lab-on-chip platforms. The standard detection method is based on the measurement of the shift of some optical quantity induced by the immobilization of target molecules at the surface of an integrated optical element upon biomolecular recognition. However, this requires the acquisition of said quantity over the whole hybridization process, which can take hours, during which any external perturbation (e.g., temperature and mechanical instability) can seriously affect the measurement and contribute to a sizeable percentage of invalid tests. Here, we present a different assay concept, named Opto-Magnetic biosensing, allowing us to optically measure off-line (i.e., post hybridization) tiny variations of the effective refractive index seen by microring resonators upon immobilization of magnetic nanoparticles labelling target molecules. Bound magnetic nanoparticles are driven in oscillation by an external AC magnetic field and the corresponding modulation of the microring transfer function, due to the effective refractive index dependence on the position of the particles above the ring, is recorded using a lock-in technique. For a model system of DNA biomolecular recognition we reached a lowest detected concentration on the order of 10 pm, and data analysis shows an expected effective refractive index variation limit of detection of 7.5×10−9 RIU, in a measurement time of just a few seconds.