Currently, treating sign language issues and producing high quality solutions has attracted researchers and practitioners’ attention due to the considerable prevalence of hearing disabilities around the world. The literature shows that Arabic Sign Language (ArSL) is one of the most popular sign languages due to its rate of use. ArSL is categorized into two groups: The first group is ArSL, where words are represented by signs, i.e., pictures. The second group is ArSl alphabetic (ArSLA), where each Arabic letter is represented by a sign. This paper introduces a real time ArSLA recognition model using deep learning architecture. As a methodology, the proceeding steps were followed. First, a trusted scientific ArSLA dataset was located. Second, the best deep learning architectures were chosen by investigating related works. Third, an experiment was conducted to test the previously selected deep learning architectures. Fourth, the deep learning architecture was selected based on extracted results. Finally, a real time recognition system was developed. The results of the experiment show that the AlexNet architecture is the best due to its high accuracy rate. The model was developed based on AlexNet architecture and successfully tested at real time with a 94.81% accuracy rate.