Permanent make-up (PMU) has become a very popular application over the last few years. The ingredients of PMU inks, used over the face area, are organic and inorganic substances very close to the chemical composition of tattoo inks. As the application rates increase, the demand for PMU removal rises. The aim of this study is to assess the decolorization of PMU inks using preparations originating from different plant sources. The leaves of Pelargonium zonale (PE) were extracted with water for 48 h. The Total Phenolic Content (TPC) of the extract was determined using the Folin–Ciocalteu technique reaching 201.34 ± 4.57 μg Gallic Acid Equivalents (GAE)/mL of extract. The antioxidant activity of the extract was 20.87 ± 0.36 μg of Trolox equivalents (TE)/mL and 3.56 ± 0.43 mg FeSO₄×7H₂O mL of extract when assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) or ferric reducing antioxidant power (FRAP) assay respectively. The decolorization potential of PE leaf extract on five commercially available PMU inks of different hues was assessed by UV-Vis spectrophotometry in comparison to polyphenol oxidases enzyme (PPO). The results demonstrated higher absorption reduction that indicates decolorization potential for the inks that have mainly ferrous oxides as colorants.