The COVID-19 pandemic caused massive use and improper disposal of surgical polypropylene (PP)-based face masks. For a first evaluation of the respective environmental consequences, we performed a 6-month microcosm experiment at 25 °C to determine the microbial degradability of 10 × 10 mm cuts of single mask layers and of a complete mask mixed with topsoil (Cambisol). By analyzing the CO₂ production, we identified a fast pool with a mean residence time (MRT_fast) of 3 to 7 days, corresponding to approximately 4 to 5% of the total mask carbon. Solid-state nuclear magnetic resonance (NMR) spectroscopy of the degraded masks suggests a cut-off of PP units or oligomers as a main degradation mechanism. The slow carbon pool of the center mask revealed an MRT_slow of 7 years and those of the remaining mask material MRT_slows between 19 and 28 years, which is three to five times longer than those of soil organic matter (SOM) of the pure soil. Since the masks were not pretreated, and decomposed in the dark without UV radiation, our data support our hypothesis that in soils, microbes must exist that can decompose PP, although their nature still has to be revealed in future attempts.