Wearable devices are commonly used to monitor human movement since motor activity is a fundamental element in all phases of a person's life. Patients with motor disorders need to be monitored for a prolonged period and the battery life can be a limit for such a goal. Here the technique of harvesting energy from body heat to supply energy to wearable devices is investigated. A commercial flexible thermoelectric generator, equipped with an accelerometer, is placed on the lower leg above the ankle. The accelerometer serves to detect diverse motor activities carried out by ten students of VSB-Technical University of Ostrava involved in the execution of two tasks. To summarize, the motor activities analyzed in the proposed work are: “Sit”, “Walk”, “Rest”, “Go biking”, “Rest after biking”, and “Go down and up the stairs”. The maximum measured value of power density was 20.3 μW cm ^-2 for the “Walk” activity, corresponding to a gradient of temperature between the hot and cold side of the thermocouples constituting the flexible thermoelectric generator of 1.5 °C, while the minimum measured value of power density was 8.3 μW cm ^-2 for the “Sit” activity, corresponding to a gradient of temperature of 1.1 °C. Moreover, a mathematical model was developed for the recognition of motor activities carried out during the execution of the experiments. As a preliminary result, it is possible to state that semi-stationary parts of the signal generated by the thermoelectric generator can be traced back to the performance of an activity.

Cardiovascular diseases are one of most frequent cause of morbidity and mortality in the world. There is an emerging need for integrated, non-invasive, and easy-to-use clinical tools to assess accurately cardiovascular system primarily in the preventative medicine. We present a novel design for a non-invasive pulse wave velocity (PWV) assessment method integrated in a single brachial blood pressure monitor allowing for up to 100 times more sensitive recording of the pressure pulsations based on a brachial occlusion-cuff (suprasystolic) principle. The monitor prototype with built-in proprietary method was validated with a gold standard reference technique SphygmoCor VX device. The blood pressure and PWV were assessed on twenty-five healthy individuals (9 women, age (37 ± 13) years) in a supine position at rest by a brachial cuff blood pressure monitor prototype, and immediately re-tested using a gold standard method. PWV using our BP monitor was (6.67 ± 0.96) m/s compared to PWV determined by SphygmoCor VX (6.15 ± 1.01) m/s. The correlation between methods using a Pearson’s correlation coefficient was r = 0.88 (p < 0.001). The study demonstrates the feasibility of using a single brachial cuff build-in technique for the assessment of the arterial stiffness from a single ambulatory blood pressure assessment.

Systemic arterial blood pressure (BP) is one of the most important parameters of the cardiovascular system. An oscillometric NIBP monitor was specifically designed to measure oscillometric pulsations and mean arterial pressure (MAP) during inflation and deflation of the cuff. Nineteen healthy young (age 23.1±1.7 years; mean±SD) and 35 elderly (83.9±7.9 years; mean±SD) subjects were studied. Differential analysis of MAP during inflation and deflation show mean |ΔMAP|=2.9±2.6 mm Hg in the young group (mean±SD) and |ΔMAP|=6.3±5.2 mm Hg for seniors (mean±SD). There was a significant difference (p<0.05) in means of |ΔMAP| measured during cuff inflation and cuff deflation between both groups. In about 50% of elderly subjects |ΔMAP| was higher than 5 mm Hg. Potential clinical relevance of the method needs to be further evaluated.

We present Breathing Friend – a portable and tangible device that uses haptic interaction to unobtrusively stimulate mindful breathing as efficient stress coping method. Its design is optimized for holding in user’s hands. By changing its shape, it sends haptic signals to the user. Several studies were conducted where we explored and verified the form factors of the artifact, interaction methods, therapeutic effect, fitting to everyday life, and influence on the breathing pattern.

Aims/Hypothesis: Beta-cell failure plays a fundamental role in type 2 diabetes mellitus (T2DM) development. It has been shown that the beta-cells are among the most sensitive to hypoxia. We aimed to analyze whether decrease in pancreatic perfusion relates to 1/decline in beta-cell function and 2/visceral fat accumulation in patients with T2DM. Methods: Fifteen women with T2DM on metformin therapy alone and fifteen women of comparable age and BMI without prediabetes/diabetes were cross-sectionally examined: clinical and anthropometric examination, fast sampled intravenous glucose tolerance test (FSIVGTT), dynamic contrast-enhanced magnetic resonance imaging to assess pancreatic perfusion (area under the curve of postcontrast saturation, AUC_TSIC), and visceral adiposity (VAT, calculated from transverse sections at the level L2–L5 vertebrae). Results: Pancreatic blood perfusion (AUC_TSIC) did not differ between groups (p = 0.273), but it negatively correlated with BMI (r = −0.434, p = 0.017), WHR (r = −0.411, p = 0.024), and VAT (r = −0.436, p = 0.016) in both groups. Moreover, AUC_TSIC in the head of the pancreas negatively correlated with the level of fasting glycemia (r = −0.401, p = 0.028) and HOMA-IR (r = −0.376, p = 0.041). Discussion/Conclusion: We showed that decreased pancreatic perfusion did not relate to beta-cell dysfunction in early stages of T2DM development, but it was related to VAT, insulin resistance, and higher fasting glycemia. Furthermore, lower pancreatic perfusion was related to VAT, insulin resistance, and higher fasting glycemia.