Objetivo: Mostrar por primera vez cómo afecta aflibercept a las lesiones de endometriosis. Material y métodos: Endometriosis inducida quir&uacu...

In this study, we aimed to determine the impact of the antiangiogenic medications, namely, aflibercept and cabergoline in the prevention and treatment of ovarian hyperstimulation syndrome in a rat model.

This debate paper aims to examine the effects of glucagon-like peptide-1 receptor agonists (GLP-1 RAs), whose use in obesity and diabetes management has rapidly expanded, on fertility, contraceptive efficacy, and pregnancy outcomes in reproductive-aged individuals, and to provide evidence-based clinical guidance. GLP-1 RAs improve fertility in obese women with polycystic ovary syndrome (PCOS) through weight reduction and enhanced insulin sensitivity, meta-analyses demonstrated significantly higher spontaneous pregnancy rates. However, gastrointestinal side effects may theoretically compromise the absorption of oral contraceptives. Animal studies indicate potential foetal risks, and limited human data support discontinuation before conception with appropriate washout periods (2-4 weeks for short-acting agents, 8 weeks for semaglutide and tirzepatide). In men, metabolic improvements may indirectly enhance reproductive parameters. From a contraceptive perspective, non-oral hormonal methods and long-acting reversible contraception may represent more reliable options during treatment, particularly in the presence of gastrointestinal side effects that could compromise oral drug absorption. GLP-1 RAs are valuable adjuncts in managing obesity-related infertility, particularly in patients with PCOS. Clinicians must counsel patients regarding contraceptive reliability during treatment, ensure adequate washout before attempting conception, and recognise that while fertility benefits are well documented, pregnancy safety data remain limited.

Composition of the vaginal microbiota in relation to cervical intraepithelial lesions - Turkish Journal of Obstetrics and Gynecology