Background: Oral nicotine pouches (ONPs) have rapidly gained popularity as a novel nicotine delivery method. However, data on ONP use, awareness, and associated beliefs in Saudi Arabia remain limited. This study aimed to investigate these aspects among adults in Riyadh region.Methods: A cross-sectional survey was conducted in 2024 involving 831 Saudi adults (age ≥ 18 years). Participants completed a self-administered questionnaire assessing ONP awareness, prevalence, beliefs, and susceptibility as well as potential associated ONP use symptoms. Logistic and multinomial regression models were employed to analyze the associations between these variables.Results: Overall, 59.3% of participants reported awareness of ONPs, and 14.2% having used them. Males were more aware (ORadj = 1.97, p < 0.0001) and user (ORadj = 2.86, p = 0.03) of ONP than females. Similarly, younger adults (aged 18–29 and 30–39 years) demonstrated higher ONP awareness (ORadj = 4.67 and 4.88, respectively, both p < 0.0001) and use (ORadj = 6.91, p < 0.002 and 6.12, p < 0.003, respectively) compared to older adults (40–69 years). Additionally, 95.8% of ONP users were smokers, more likely to be cigarette (ORadj = 9.53, p < 0.0001) or e-cigarette (ORadj = 8.43, p < 0.0001) smokers. Approximately 60% of participants demonstrated susceptibility to ONP use, characterized by curiosity, limited knowledge of health risks, and potential willingness to use. Favorable beliefs about ONPs were more prevalent among users. Furthermore, a positive correlation was observed between the frequency of ONP use and the likelihood of experiencing associated symptom (r = 0.3, p = 0.0009), with abdominal symptoms being the most reported symptom.Conclusion: Given that 95.8% of ONP users in this study were smokers, these findings suggest a potential future role for ONPs as a harm reduction strategy within the context of smoking cessation in Saudi population in Riyadh. However, continuous surveillance and targeted public health interventions are crucial to mitigate the potential negative consequences associated with ONP use.

Background and Objectives: This study aimed to assess the dental anxiety of patients using the modified dental anxiety scale (MDAS) questionnaire along with examining the possible relationship between dental anxiety and sociodemographic factors. Materials and Methods: The MDAS questionnaire was used to assess the anxiety level of the patients which included a total of five questions and five options to respond to each question. MDAS questionnaire was filled out by all the patients before the dental treatment. After finishing the treatment, all the patients were given a post-treatment questionnaire to assess their anxiety levels after treatment. Descriptive statistics were performed for measuring the frequency of responses. Mann-Whitney U test was used to compare the anxiety between the gender. The chi-square test was used to identify the distribution of pre-treatment with gender and post-treatment questionnaire with gender and treatment modalities. Linear regression was used to identify the association between clinical variables and different levels of anxiety. Results: A total of 115 patients including 59 males and 56 females with a mean age of 35 ± 11.34 years were included in the current study. Female patients were significantly more anxious about dental treatment compared to male patients. Linear regression showed that age and gender have a significant association with the pre-treatment anxiety level; however, types of treatment is not associated with the MDAS. Anxiety levels decreased for the majority of the patients after the treatment and types of treatment did not show any differences with the post-treatment anxiety level. Conclusions: Age and gender play an important role in dental anxiety; however, types of treatment are not associated with pre-treatment and post-treatment dental anxiety.

Background: To date, little is known about the salivary mucosal immune response following different COVID-19 vaccine types or after a booster (3rd) dose of the BNT162b2 (BNT) vaccine. Methods: A total of 301 saliva samples were collected from vaccinated individuals and arranged into two cohorts: cohort 1 (n = 145), samples from individuals who had received two doses against SARS-CoV-2; cohort 2 (n = 156), samples from individuals who had received a booster of BNT vaccine. Cohorts 1 and 2 were sub-stratified into three groups based on the types of first and second doses (homologous BNT/BNT, homologous ChAdOx1/ChAdOx1, or heterologous BNT/ChAdOx1vaccinations). Salivary immunoglobulin G (IgG) response to SARS-CoV-2 spike glycoprotein was measured by ELISA, and clinical demographic data were collected from hospital records or questionnaires. Results: Salivary IgG antibody responses against different vaccines, whether homologous or heterogeneous vaccination regimens, showed similar levels in cohorts 1 and 2. Compiling all groups in cohort 1 and 2 showed significant, albeit weak, negative correlations between salivary IgG levels and time (r = −0.2, p = 0.03; r = −0.27, p = 0.003, respectively). In cohort 2, the durability of salivary IgG after a booster dose of BNT162b2 significantly dropped after 3 months compared to the <1 month and 1–3 months groups. Conclusions: Different COVID-19 vaccine types and regimens elicit similar salivary anti-SARS-CoV-2 IgG with modest waning over time. Boosting with BNT162b2 vaccine did not produce an evident increase in mucosal IgG response whereby COVID-19 recovered subjects show higher salivary IgG than naive, post-vaccination subjects. The ChAdOx1/ChAdOx1 regimen showed better correlation between salivary IgG levels and durability. These findings highlight the importance of developing oral or intra-nasal vaccines to induce stronger mucosal immunity.

(1) Background: The purpose of this prospective study was to determine the changes in primary hemodynamic parameters and oxygen saturation in systemically healthy patients during the surgical procedure involving crown lengthening. (2) Methods: A total of 44 patients who required a crown-lengthening procedure in a single tooth in the maxillary arch were included in this study. Heart rate (HR), blood pressure (BP) and oxygen saturation (SpO₂) were measured in all the subjects at three different intervals: before injecting the anesthetic (T1), after the anesthetic injection (T2) and after the procedure (T3). Descriptive statistics were computed, and observations were recorded as mean and standard deviation (SD). Analysis of variance (ANOVA) was used to compare the mean observation within parameters at different time intervals. (3) Results: All primary hemodynamic parameters were increased in the T2 phase over T1 and decreased in the T3 phase over T2. However, SpO₂ decreased in both the T2 and T3 phases compared to the initial T1 phase. No significant differences were observed among the primary hemodynamic variables. However, SpO₂ showed a significant difference (p = 0.013) among the T1, T2 and T3 phases. (4) Conclusions: Further study with larger sample size is required in order to analyze the accurate hemodynamic alterations.

Emerging evidence suggests a potential association between periodontitis and adverse outcomes in COVID-19. Both conditions share risk factors and exhibit similar immune dysregulation, including elevated pro-inflammatory cytokines, altered myeloid compartments, and T-cell dysfunction. SARS-CoV-2 uses angiotensin-converting enzyme type 2 and transmembrane protease serine 2 membrane proteins, highly expressed in the oral cavity, for cellular entry. Periodontitis may exacerbate COVID-19 through mechanisms such as oral microbe aspiration, increased viral receptor expression, and systemic inflammation. The shared immunopathogenesis, characterized by cytokine storms and perturbed immune profiles, suggests periodontitis can predispose patients to more severe COVID-19 outcomes. This article aims to review the associations between periodontitis and the severity of COVID-19 and the possible immune mechanisms involved.

Background/Objectives: Oral nicotine pouches (ONPs) have rapidly gained popularity as a novel nicotine delivery method. However, data on ONP use, awareness, and associated beliefs in Saudi Arabia remain limited. This study aimed to investigate these aspects among adults in Riyadh region. Methods: A cross-sectional survey was conducted in 2024 involving 831 Saudi adults (age ≥ 18 years). Participants completed a self-administered questionnaire assessing ONP awareness, prevalence, beliefs, and susceptibility as well as potential associated ONP use symptoms. Logistic and multinomial regression models were employed to analyze the associations between these variables. Results: Overall, 59.3% of participants reported awareness of ONPs, and 14.2% having used them. Males were more aware (ORadj= 1.97, p< 0.0001) and user (ORadj= 2.86, p= 0.03) of ONP than females. Similarly, younger adults (aged 18-29 and 30-39 years) demonstrated higher ONP awareness (ORadj= 4.67 and 4.88, respectively, both p< 0.0001) and use (ORadj= 6.91, p< 0.002 and 6.12, p< 0.003, respectively) compared to older adults (+40 years). Additionally, 95.8% of ONP users were smokers, more likely to be cigarette (ORadj= 9.53, p< 0.0001) or e-cigarette (ORadj= 8.43, p< 0.0001) smokers. Approximately 60% of participants demonstrated susceptibility to ONP use, characterized by curiosity, limited knowledge of health risks, and potential willingness to use. Favorable beliefs about ONPs were more prevalent among users. Furthermore, a positive correlation was observed between the frequency of ONP use and the likelihood of experiencing associated symptom (r= 0.3, p= 0.0009). Conclusions: Given that 95.8% of ONP users in this study were current smokers, these findings suggest a potential future role for ONPs as a harm reduction strategy within the context of smoking cessation in Saudi population in Riyadh. However, continuous surveillance and targeted public health interventions are crucial to mitigate the potential negative consequences associated with ONP use.