Chiahui Yen

Dr. Chiahui Yen

orcid

Research Focus & Metrics

Academic Career Length

15Years (2012-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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29 June 2023 in Life
Verified
Journal Article
Open access
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Chiahui YenChiahui Yen
Chiahui Yen
CLChia-Li Lin
Chia-Li Lin
Ming-Chang ChiangMing-Chang Chiang
Ming-Chang Chiang
Neuroimaging has revolutionized our understanding of brain function and has become an essential tool for researchers studying neurological disorders. Functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) are two widely used neuroimaging techniques to review changes in brain activity. fMRI is a noninvasive technique that uses magnetic fields and radio waves to produce detailed brain images. An EEG is a noninvasive technique that records the brain’s electrical activity through electrodes placed on the scalp. This review overviews recent developments in noninvasive functional neuroimaging methods, including fMRI and EEG. Recent advances in fMRI technology, its application to studying brain function, and the impact of neuroimaging techniques on neuroscience research are discussed. Advances in EEG technology and its applications to analyzing brain function and neural oscillations are also highlighted. In addition, advanced courses in neuroimaging, such as diffusion tensor imaging (DTI) and transcranial electrical stimulation (TES), are described, along with their role in studying brain connectivity, white matter tracts, and potential treatments for schizophrenia and chronic pain. Application. The review concludes by examining neuroimaging studies of neurodevelopmental and neurological disorders such as autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), Alzheimer’s disease (AD), and Parkinson’s disease (PD). We also described the role of transcranial direct current stimulation (tDCS) in ASD, ADHD, AD, and PD. Neuroimaging techniques have significantly advanced our understanding of brain function and provided essential insights into neurological disorders. However, further research into noninvasive treatments such as EEG, MRI, and TES is necessary to continue to develop new diagnostic and therapeutic strategies for neurological disorders.

27 February 2015 in Behaviour & Information Technology
Verified
Journal Article
Closed access
Chiahui YenChiahui Yen
Chiahui Yen
This study aims to investigate users’ knowledge-sharing intention and collective stickiness intention towards social network sites (SNS). SNS offer an opportunity for users to interact and form relationships, while knowledge is accrued by integrating users’ information, experience, and practice. However, there have been few systematic studies that question why people use SNS to share knowledge. We adopt social capital theory, social identity theory, as well as use and gratification theory, to explore the determinants of members’ knowledge-sharing intention in using SNS. The survey was conducted on two education virtual communities (VCs) on Facebook, of which most members were teachers and educators. Data analysis was executed to validate our research model, and SmartPLS was used to analyse users’ collective stickiness intention. The results show that social capital and social identity have an impact on teachers’ knowledge-sharing intention, which, in turn, influences collective stickiness intention towards SNS. Our findings can not only help researchers interpret why members share their knowledge in VCs, but can assist practitioners in developing better SNS strategies as well.

9 September 2022 in Sustainability
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Journal Article
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Ming-Chang ChiangMing-Chang Chiang
Ming-Chang Chiang
Chiahui YenChiahui Yen
Chiahui Yen
HCHsiu-Li Chen
Hsiu-Li Chen
In recent years, online shopping platforms have displayed more sustainable products to attract consumer attention. Understanding the effect of age on online shopping patterns can provide a broader understanding of the critical role of consumer attention. Physiological measures can explain consumers’ responses to features of online shopping websites and help these companies understand the decision-making process of consumers by using neuroscience-integrated tools. When consumers browse and shop on a platform, their eyes constantly move, effectively scanning the area of interest to capture information. This study attempts to evaluate the impact of consumer age on psychological and physiological responses to online shopping platforms by using eye tracking, EEG recordings, and FaceReader software. Eye tracker data on the average duration and number of fixations and saccades indicated that the older group had fewer eye movements than the younger group. The temporal and frontal cortices of the younger and older groups showed differences in EEG activity. The research also analyzed the faces of younger and older adults using FaceReader software; the main differences occured in the happy, surprised, and neutral expressions observed. This study enhances our understanding of the psychology and behavior of younger and older people in neuromarketing research, combining noninvasive physiological and neuroscience methods to present psychological data.

13 February 2025 in Life
Verified
Journal Article
Open access
PDF file
Ming-Chang ChiangMing-Chang Chiang
Ming-Chang Chiang
YYYu-Ping Yang
Yu-Ping Yang
CNChristopher Nicol
Christopher Nicol
TCTairui Chiang
Tairui Chiang
Chiahui YenChiahui Yen
Chiahui Yen
Parkinson’s disease (PD) is a progressive neurodegenerative disorder primarily characterized by the loss of dopaminergic neurons in the substantia nigra. Mitochondrial dysfunction, oxidative stress, and neuroinflammation are recognized as critical pathological mechanisms driving neurodegeneration in PD. Exosome (Exo)-based therapies, particularly those derived from human neural stem cells (hNSCs), offer promising neuroprotective effects due to their ability to transfer bioactive molecules that modulate cellular processes. Resveratrol (RES), a polyphenolic compound with potent antioxidant and anti-inflammatory properties, has been shown to enhance the therapeutic potential of stem cell (SC)-derived Exos. This study investigated the neuroprotective effects of RES-treated hNSCs-derived Exos (RES-hNSCs-Exos) on SH-SY5Y cells exposed to 1-methyl-4-phenylpyridinium (MPP+), a neurotoxin commonly used to model Parkinsonian neurotoxicity. Treating SH-SY5Y cells with MPP+ led to significant reductions in cell viability, mitochondrial dysfunction, increased oxidative stress, and the activation of inflammatory pathways. Treatment with RES-hNSCs-Exos rescued SH-SY5Y cells from MPP+-induced toxicity by improving cell viability, enhancing ATP production, increasing mitochondrial biogenesis, and reducing reactive oxygen species (ROS) generation. The findings also demonstrated the increased expression of essential genes involved in mitochondrial biogenesis, such as PGC1α, NRF1, and Tfam, indicating improved mitochondrial function in the presence of RES-hNSCs-Exos. Further analysis revealed that these protective effects were mediated by activating the AMP-activated protein kinase (AMPK) and Nrf2 signaling pathways, which promoted mitochondrial health and reduced oxidative stress. Moreover, RES-hNSCs-Exos treatment suppressed neuroinflammation by downregulating NLRP3 inflammasome activation and reducing the secretion of pro-inflammatory cytokines IL-1β and IL-18. In conclusion, the results suggest that RES-hNSCs-Exos exhibit potent neuroprotective effects against MPP+-induced neurotoxicity by enhancing mitochondrial function, reducing oxidative stress, and inhibiting neuroinflammation. These findings highlight the potential of hNSCs-Exos as a novel therapeutic strategy for neurodegenerative diseases like PD, with RES as a valuable enhancer of Exos efficacy.

21 September 2012 in Information Systems and e-Business Management
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Journal Article
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Chiahui YenChiahui Yen
Chiahui Yen
MHMeng-Hsiang Hsu
Meng-Hsiang Hsu
CCChun-Ming Chang
Chun-Ming Chang

13 December 2013 in Human Systems Management
Verified
Journal Article
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CCChao-Min Chiu
Chao-Min Chiu
YFYu-Hui Fang
Yu-Hui Fang
HCHsiang-Lan Cheng
Hsiang-Lan Cheng
Chiahui YenChiahui Yen
Chiahui Yen
This study investigates the repeat purchase intention of experienced online buyers. In the research model, psychological contract violation is proposed as a formative second-order construct driven by distributive justice, procedural justice, interpersonal justice, and informational justice. Psychological contract violation is hypothesized to negatively affect satisfaction and trust in the online store, which in turn are hypothesized to positively affect repeat purchase intentions. Switching cost is hypothesized to negatively moderate the effects of satisfaction and trust on repeat purchase intention. Data collected from 162 of PChome's customers provide partial support for the research model. Results indicate that psychological contract violation is negatively associated with satisfaction and trust. Satisfaction is positively associated with buyers' repeat purchase intentions. A higher level of switching cost diminished satisfaction's effect on repeat purchase intention. Implications for theory and practice are discussed, and suggestions for future research are offered.