Gastrointestinal symptoms are common in critically ill COVID-19 patients. There is currently no generally recognized method of assessing gastrointestinal injury in unconscious or sedated intensive care unit (ICU) patients. I-FABP (intestinal fatty acid binding protein) and citrulline have previously been studied as potential biomarkers of enterocyte damage in various gastrointestinal tract diseases, and changes in the levels of these markers may reflect intestinal wall damage in COVID-19. Patients with critical COVID-19, with diagnosed sepsis, or septic shock requiring ICU treatment were included in the study. Blood samples for citrulline and I-FABP were taken daily from day 1 to 5. I-FABP levels were significantly higher in patients who eventually died from COVID-19 than in survivors, and the optimal I-FABP cut-off point for predicting 28-day mortality was 668.57 pg/mL (sensitivity 0.739, specificity 0.765). Plasma levels of I-FABP, but not citrulline, were associated with significantly higher mortality and appeared to be a predictor of poor outcome in multivariate logistic regression analysis. In conclusion, I-FABP seems to be an effective prognostic marker in critically ill COVID-19 patients. Assessing mortality risk based on intestinal markers may be helpful in making clinical decisions regarding the management of intestinal injury, imaging diagnostics, and potential surgical interventions.

The SARS-CoV-2 virus alters the expression of genes for extracellular matrix proteins, including fibronectin. The aim of the study was to establish the relationship between different forms of fibronectin, such as plasma (pFN), cellular (EDA-FN), and proteolytic FN-fragments, and disease severity and mortality of critically ill patients treated in the intensive care unit. The levels of pFN, EDA-FN, and FN-fragments were measured in patients with a viral (N = 43, COVID-19) or bacterial (N = 41, sepsis) infection, using immunoblotting and ELISA. The level of EDA-FN, but not pFN, was related to the treatment outcome and was significantly higher in COVID-19 Non-survivors than in Survivors. Furthermore, EDA-FN levels correlated with APACHE II and SOFA scores. FN-fragments were detected in 95% of COVID-19 samples and the amount was significantly higher in Non-survivors than in Survivors. Interestingly, FN-fragments were present in only 56% of samples from patients with bacterial sepsis, with no significant differences between Non-survivors and Survivors. The new knowledge gained from our research will help to understand the differences in immune response depending on the etiology of the infection. Fibronectin is a potential biomarker that can be used in clinical settings to monitor the condition of COVID-19 patients and predict treatment outcomes.

In this article, we want to describe the opportunities we experienced though involvement with the AACE and EACE to improve cancer education in poland from our points of view as fifth-year medicine students. By participating in the annual meeting of the EACE that our university (Wroclaw ) hosted and also the ESMI-ESO course on medical oncology for medical students, we were able to improve our doctor- patient skills and deepen our knowledge caring for cancer patients. In our opinion in the obligatory medical curriculum in Poland, the curricular offerings in oncology should be better coordinated and there is too little attention to the teaching of the so called “soft skills” for future doctors. Over the course our studies, we are taught a great deal about the biology, diagnosis and symptomatology of cancer; however, we are not exposed very much to issues of communication between the doctor and the oncology patient, or appropriate strategies to pass information about the diagnosis and prognosis. Therefore, we feel that it is important for the future for students to learn more about such topics. Many do this in informal, extracurricular ways as there is much interest to learn about such topics and we will discuss several useful tools. In this review, we would like to summarize the current state of oncology education in Poland and our hopes for improving the current state and to emphasize how inspiring it was for us to participate in an international cancer education meeting where we could discuss good ideas from all over the world and bring them home to Poland.