The aim of the present study was to measure the free carnitine and acylcarnitine levels in pterygium tissue and normal conjunctival tissue at the metabolomics level using tandem mass spectrometry. In this prospective, clinical randomized study, pterygium tissues and normal conjunctival tissues taken during pterygium excision with autograft were compared regarding their free carnitine and acylcarnitine profiles. After tissue homogenization, carnitine levels were measured using tandem mass spectrometry. The data were statistically analyzed with the Wilcoxon signed-rank test. Pterygium and normal conjunctival tissue samples from a single eye of 29 patients (16 females, 13 males; mean age, 54.75 ± 11.25 years [range, 21-78 years]) were evaluated. While the free carnitine (C0) level was significantly high in the pterygium tissue (p<0.001), acylcarnitine levels were significantly high in some esterized derivatives (C2, C5, C5:1, C5DC, C16:1, C18, methylglutarylcarnitine) (p0.05). That the carnitine levels in pterygium tissue were higher suggests that acceleration of cell metabolism developed secondary to chronic inflammation and the premalignant characteristics of pterygium tissue. High carnitine levels may also effectively suppress the apoptosis process. The data reported in our study indicate that further, more extensive studies of the carnitine profile could help clarify the pathogenesis of pterygium.

Aims: To compare retinal nerve fiber layer (RNFL) thickness and choroidal thickness in patients with exfoliation syndrome (XFS) and exfoliative glaucoma (XFG) for 1–5 years or 6–10 years compared to healthy volunteers. Methods and Material: Seventy-eight eyes of 78 patients with XFG, 78 eyes of 78 patients with XFS, and 83 eyes of 83 healthy individuals were included in this prospective study. SD-OCT data for choroid thickness and RNFL were recorded. Results: RNFL thickness was statistically significantly lower in eyes with XFG and XFS than in the control group (p < 0.001). Macular choroidal thickness decreased significantly in the XFG group compared to the XFS and control groups (p < 0.001). No significant difference was observed between the XFS and control groups (p > 0.05). In terms of choroidal and RNFL thicknesses by years in XFG and XFS patients, values were lower in the patients diagnosed 6–10 years previously than in those diagnosed 1–5 years previously. However, the difference was not statistically significant (p > 0.05). Conclusions: Thinning of both choroidal and RNLF thickness in XFG and XFS patients may mean that PEX material is an important risk factor for the progression of XFS to XFG. In addition, thinner choroid and RNLF thickness in the 6–10 years groups show the effect of PEX material and the importance of time.

Purpose: This study aimed to investigate the effects of metabolic and bariatric surgery (MBS) on the corneal and anterior segment parameters of the eye. Materials and Methods: In this study, the anterior chamber depth, volume, angle and central corneal thickness of obese patients who underwent laparoscopic sleeve gastrectomy surgery were prospectively examined using Pentacam topography before and six months after surgery. Results: A total of 112 eyes of 56 individuals, including 26 males with a mean age of 38.88 ± 7.00 years and 30 females with a mean age of 40.94 ± 7.76 years, were evaluated (p = 0.310). Six months following MBS, the average body mass index (BMI) in men decreased from 45.5 kg/m² to 34 kg/m² (p < 0.001), and the BMI decreased from 47 kg/m² to 33 kg/m² (p < 0.001) in women. Central corneal thickness and intraocular pressure decreased significantly in both men and women. The anterior chamber depth, volume and angle ​​significantly increased six months after surgery (p < 0.001 for all parameters). A statistically significant negative correlation was observed between postoperative BMI and anterior chamber depth, volume and angle in both sexes (p < 0.001 for all). Conclusion: This study revealed that anterior segment values, intraocular pressure, and corneal thickness may change after MBS. Caution should be exercised when evaluating for cataracts and refractive surgery after MBS. Graphical

Purpose: Evaluation of anterior segment parameters using the Scheimpflug corneal topography 1 year after surgery in patients who underwent sutureless scleral fixation intraocular lens (SFIOL) implantation using the modified Yamane technique and retropupillary iris-claw intraocular lens (RPIOL) implantation. Methods: A total of 60 eyes from 57 patients who underwent sutureless SFIOL implantation and 57 eyes from 52 patients who underwent RPIOL implantation were included. Anterior chamber depth (ACD), anterior chamber angle (ACA), anterior chamber volume (ACV), anterior–posterior corneal astigmatism, and keratometric values were assessed using the Scheimpflug corneal topography (Pentacam HR, Germany). Results: There was no statistically significant difference in postoperative UCVA and BCVA between the sutureless SFIOL and the RPIOL group (p = 0.236, p = 0.293, respectively). While there was no statistically significant difference in postoperative IOP between the two groups (p = 0.223), a statistically significant decrease in IOP was observed in both groups (p < 0.001). While there was no statistical difference between the sutureless SFIOL group and the RPIOL group in terms of spherical value (p = 0.441) and spherical equivalence (p = 0.237), there was a statistically significant difference in cylindrical value (p < 0.001). While there was a statistical difference in anterior astigmatism (p < 0.001), there was no statistical difference in posterior astigmatism (p = 0.405). There was no statistical difference in terms of ACV, ACD, and ACA between the sutureless SFIOL and the RPIOL group (p = 0.812, p = 0.770, p = 0.401, respectively). Conclusion: In this study, although there was a statistical difference in cylindrical value and anterior corneal astigmatism between the sutureless SFIOL and RPIOL groups, vision was not affected. According to this study, sutureless SFIOL and RPIOL are two successful methods in terms of visual acuity, anterior segment, and keratometry outcomes in aphakic patients after phacoemulsification.

Purpose: This study aimed to evaluate the effect of inferior oblique myectomy (IOM) surgery on the cornea and anterior segment. Methods: The sheimpflug corneal topographies of 56 eyes of 33 patients who underwent IOM were analyzed at preoperative, postoperative 1 week, 1 month, 3 months, and 6 months. Astigmatism degree (Cyl), astigmatism axis (Ax), K1, central corneal thickness (CCT), anterior chamber depth (ACD), anterior chamber volume (ACV), iridocorneal angle (ICA), and horizontal visible iris diameter (HVID) were evaluated. Results: The mean corneal Cyl, K1, ICA, ACD, and HVID did not change after IOM (p=0.671, p=0.377, p=0.431, p=0.588, p=0.795, respectively). There was a statistically significant change in Ax (p=0.025). The right Ax decreased, and the left Ax increased the most at 1 month (p=0.025, p=0.882, respectively). Ax increase was also detected in the left eye that was not operated on. The mean CCT increased and mean ACV decreased at 1 month (p=0.588, p=0.270, respectively), but these changes returned to preoperative values at 3 months. Conclusion: The manifestation of anterior segment alterations and intorsion in both eyes following inferior oblique myectomy may contribute to diminished visual acuity and the potential onset of amblyopia. These alterations merit consideration during the assessment, and if deemed necessary, the provision of new spectacles should be considered as a preventive measure against anisometropic amblyopia.

Amaç: Göz içi basıncı yüksekliği olan hifemalı hastalarda tedavi yaklaşımı ve sonuç görmeye etkili faktörlerin incelenmesi.Gereç ve Yöntem: Ağustos 2015 ve Ağustos 2019 tarihleri arasında tanı ve tedavisi yapılmış 55 hastanın dosyası retrospektif olarak incelendi.Bulgular: Hastaların %44’ü 10-20 yaş aralığında idi. Künt travmatik hifemaya en sık neden olan etyolojik faktör odun parçası (%37,5) idi. Medikal tedavi 38 (%69,1) hastada GİB’ını 25 mmHg altına düşürerek etkili oldu. Medikal tedavi ile GİB düşüşü sağlanamayan 12 (%2,8) hastaya ön kamara lavajı, 2 (%3,6) hastaya ön vitrektomi, 2 (%3,6) hastaya katarakt ekstraksiyonu yapıldı. Ön kamara lavajına rağmen GİB yüksekliği mevcut olan 1 (%1,8) hastaya trabekülektomi uygulandı. Görmeyi etkileyen en önemli faktörün bu hastalarda oluşan ek retinal hasar olduğu tespit edildi.Sonuç: Hifemanın en sık komplikasyonu olan GİB yüksekliğinde medikal tedaviye ek olarak cerrahi tedavi gerekebilir. Yüksek seviye hifema miktarıyla birlikte arka segment bulgularının varlığı sonuç görme keskinliğini daha kötü etkilemektedir.