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Prof. Dr. Rodica Mihaela Dinica
University "Dunarea de Jos of Galati

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0 Antioxidants
0 Cytotoxicity
0 Essential Oils
0 Organic Chemistry
0 polyphenols

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Journal article
Published: 14 June 2021 in Nanomaterials
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Root extracts from Danube Delta Nymphaea alba were used to prepare gold nanoparticles (AuNPRn) by reducing HAuCl4 at different pHs (6.4–8.4) using ultrasonic irradiation: an easy, cheap, eco-friendly and green approach. Their antibacterial and anticancer activities were evaluated against Staphylococcus aureus and Escherichia coli, and A2780 ovarian cancer cells, respectively. The AuNPRn were characterized concerning their phytoconstituents (polyphenols, flavonoids and condensed tannins) and gold content. All of the nanoparticles were negatively charged. AuNPRn exhibited a hydrodynamic size distribution ranging from 32 nm to 280 nm, with the larger nanoparticles being obtained with an Au/root extract ratio of 0.56, pH 7 and 10 min of sonication (AuNPR1), whereas the smallest were obtained with an Au/root extract ratio of 0.24, pH 7.8 and 40 min of sonication (AuNPR4). The TEM/SEM images showed that the AuNPRn had different shapes. The ATR-FTIR indicated that AuNPRn interact mainly with hydroxyl groups present in the polyphenol compounds, which also confirm their high antioxidant capacity, except for AuNPR2 obtained at pH 6.4. Among the AuNPRn, the smallest ones exhibited enhanced antimicrobial and anticancer activities.

ACS Style

Mihaela Cudalbeanu; David Peitinho; Francisco Silva; Rosa Marques; Teresa Pinheiro; Ana Ferreira; Fernanda Marques; António Paulo; Catarina Soeiro; Sílvia Sousa; Jorge Leitão; Aurel Tăbăcaru; Sorin Avramescu; Rodica Dinica; Maria Campello. Sono-Biosynthesis and Characterization of AuNPs from Danube Delta Nymphaea alba Root Extracts and Their Biological Properties. Nanomaterials 2021, 11, 1562 .

AMA Style

Mihaela Cudalbeanu, David Peitinho, Francisco Silva, Rosa Marques, Teresa Pinheiro, Ana Ferreira, Fernanda Marques, António Paulo, Catarina Soeiro, Sílvia Sousa, Jorge Leitão, Aurel Tăbăcaru, Sorin Avramescu, Rodica Dinica, Maria Campello. Sono-Biosynthesis and Characterization of AuNPs from Danube Delta Nymphaea alba Root Extracts and Their Biological Properties. Nanomaterials. 2021; 11 (6):1562.

Chicago/Turabian Style

Mihaela Cudalbeanu; David Peitinho; Francisco Silva; Rosa Marques; Teresa Pinheiro; Ana Ferreira; Fernanda Marques; António Paulo; Catarina Soeiro; Sílvia Sousa; Jorge Leitão; Aurel Tăbăcaru; Sorin Avramescu; Rodica Dinica; Maria Campello. 2021. "Sono-Biosynthesis and Characterization of AuNPs from Danube Delta Nymphaea alba Root Extracts and Their Biological Properties." Nanomaterials 11, no. 6: 1562.

Journal article
Published: 25 February 2021 in Agronomy
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The purpose of this study was to assess the suitability of the Romanian Albanus hybrid of Sorghum bicolor as a potential functional food ingredient. Ultrasound-assisted extraction in different solvents, together with spectrophotometric and chromatographic methods, was used to monitor the variation in total phenolic and flavonoid content and the antioxidant activity of raw sorghum grains before and during short germination periods (24, 36 and 48 h). The High-Performance Liquid Chromatography with Diode-Array Detection (HPLC-DAD) investigation of the extracts revealed that the ungerminated sorghum grains extracted with methanol had the highest diversity of phenolic compounds, while the total phenolic content (TPC) was the highest after 36 h of germination in both extract types: 1853 mg GAE/100 g for the methanolic extract and 1726 mg GAE/100 g for the ethanolic extract. The findings of this study showed that the TPC of sorghum extracts is strongly correlated with their antioxidant activity and, overall, that the studied extracts presented a good radical scavenger activity, which supports the benefits of alimentary uses of Sorghum bicolor grains.

ACS Style

Ioana Ghinea; Maria Ionica Mihaila; Giorgiana-Valentina Blaga (Costea); Sorin Avramescu; Mihaela Cudalbeanu; Simona-Florina Isticioaia; Rodica Dinica; Bianca Furdui. HPLC-DAD Polyphenolic Profiling and Antioxidant Activities of Sorghum bicolor during Germination. Agronomy 2021, 11, 417 .

AMA Style

Ioana Ghinea, Maria Ionica Mihaila, Giorgiana-Valentina Blaga (Costea), Sorin Avramescu, Mihaela Cudalbeanu, Simona-Florina Isticioaia, Rodica Dinica, Bianca Furdui. HPLC-DAD Polyphenolic Profiling and Antioxidant Activities of Sorghum bicolor during Germination. Agronomy. 2021; 11 (3):417.

Chicago/Turabian Style

Ioana Ghinea; Maria Ionica Mihaila; Giorgiana-Valentina Blaga (Costea); Sorin Avramescu; Mihaela Cudalbeanu; Simona-Florina Isticioaia; Rodica Dinica; Bianca Furdui. 2021. "HPLC-DAD Polyphenolic Profiling and Antioxidant Activities of Sorghum bicolor during Germination." Agronomy 11, no. 3: 417.

Journal article
Published: 29 November 2020 in Foods
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Food pathogens represent an important health threat, and it is relevant to study the effect of foodstuffs such as spices which can inhibit bacterial growth. This study reports the antimicrobial, antibiofilm, and enzyme (Acetylcholinesterase, Butyrylcholinesterase, urease, tyrosinase) inhibitory activities of two medicinal food spices belonging to the Annonaceae family, Monodora myristica and Xylopia aethiopica. GC-MS (gas chromatography mass spectrometry) analysis of silylated samples of Methanol-Dicloromethane (50:50) extracts of both plants led to the identification of nine compounds in M. myristica and seven compounds in X. aethiopica. M. myristica and X. aethiopica had the same minimum inhibitory concentration (MIC) values of 0.625 mg/mL and 2.5 mg/mL on C. albicans and E. coli, respectively. However, M. myristica had better activity than X. aethiopica on Staphylococcus aureus, while Pseudomonas aeruginosa was more susceptible to X. aethiopica than M. myristica. The lowest MIC value was 0.1325 mg/mL, exhibited by M. myristica on S. aureus. Both extracts showed good antibiofilm activity. On S. aureus, at the same concentration, M. myristica had better antibiofilm activity than X. aethiopica. On E. coli and Candida albicans, X. aethiopica had better antibiofilm activity than M. myristica at the same concentration. X. aethiopica showed better violacein inhibition in Chromobacterium violaceum CV12472, as its percentage inhibition of violacein varied from 80.5% ± 3.0% at MIC to 5.6 ± 0.2 at MIC/8, as compared to M. myristica with 75.1% ± 2.5% at MIC and 15.5% ± 1.1% at MIC/8. The anti-motility activity by swimming and swarming inhibition on P. aeruginosa PA01 was low at test concentrations and in both models, M. myristica showed higher motility inhibition than X. aethiopica. Although in enzyme inhibitory assays all extracts had low inhibitions compared to standards tested at the same concentrations, the results show that these plants can be used to manage food-borne infections.

ACS Style

Alfred Ngenge Tamfu; Ozgur Ceylan; Selcuk Kucukaydin; Mehmet Ozturk; Mehmet Emin Duru; Rodica Mihaela Dinica. Antibiofilm and Enzyme Inhibitory Potentials of Two Annonaceous Food Spices, African Pepper (Xylopia aethiopica) and African Nutmeg (Monodora myristica). Foods 2020, 9, 1768 .

AMA Style

Alfred Ngenge Tamfu, Ozgur Ceylan, Selcuk Kucukaydin, Mehmet Ozturk, Mehmet Emin Duru, Rodica Mihaela Dinica. Antibiofilm and Enzyme Inhibitory Potentials of Two Annonaceous Food Spices, African Pepper (Xylopia aethiopica) and African Nutmeg (Monodora myristica). Foods. 2020; 9 (12):1768.

Chicago/Turabian Style

Alfred Ngenge Tamfu; Ozgur Ceylan; Selcuk Kucukaydin; Mehmet Ozturk; Mehmet Emin Duru; Rodica Mihaela Dinica. 2020. "Antibiofilm and Enzyme Inhibitory Potentials of Two Annonaceous Food Spices, African Pepper (Xylopia aethiopica) and African Nutmeg (Monodora myristica)." Foods 9, no. 12: 1768.

Journal article
Published: 23 November 2020 in Molecules
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Cucurbitaceae is a family of health-promoting plants due to their compounds with beneficial effects. The aim of this study was to analyze, for the first time, the chemical composition, the antioxidant activity and the metal chelating properties of fruit juices obtained from four different species of the Cucurbitaceae family cultivated in Romania, namely Momordica charantia, Cucumis metuliferus, Benincasa hispida and Trichosanthes cucumerina. The samples of juice were analyzed by high-performance liquid chromatography (HPLC) and all the four species displayed high levels of the two triterpenes, oleanolic and ursolic acids, and also in phenolic compounds, including catechin, (−)-epicatechin and gallic acid. The juices demonstrated significant antioxidant activity against the free radical 2,2-diphenyl-1-picrylhydrazyl (ranging from 20 to 95%,), a good iron binding ability (ranging from 7.45 ± 0.28% to 86.95 ± 0.97%) and also promising antioxidant potential against the ABTS radical (ranging from 4.97 to 32.60 μETx/mL juice). Our findings raise interesting questions for further research on Cucurbitaceae fruit juices and, consequently, their very good antioxidant potential suggests these fruits should be further explored for their protective effect against oxidative damage. This is the first time the chemical composition and antioxidant activities of fruit juices from these four Romanian Cucurbitaceae varieties have been investigated.

ACS Style

Anna Cazanevscaia Busuioc; Andreea-Veronica Dediu Botezatu; Bianca Furdui; Costel Vinatoru; Filippo Maggi; Giovanni Caprioli; Rodica-Mihaela Dinica. Comparative Study of the Chemical Compositions and Antioxidant Activities of Fresh Juices from Romanian Cucurbitaceae Varieties. Molecules 2020, 25, 5468 .

AMA Style

Anna Cazanevscaia Busuioc, Andreea-Veronica Dediu Botezatu, Bianca Furdui, Costel Vinatoru, Filippo Maggi, Giovanni Caprioli, Rodica-Mihaela Dinica. Comparative Study of the Chemical Compositions and Antioxidant Activities of Fresh Juices from Romanian Cucurbitaceae Varieties. Molecules. 2020; 25 (22):5468.

Chicago/Turabian Style

Anna Cazanevscaia Busuioc; Andreea-Veronica Dediu Botezatu; Bianca Furdui; Costel Vinatoru; Filippo Maggi; Giovanni Caprioli; Rodica-Mihaela Dinica. 2020. "Comparative Study of the Chemical Compositions and Antioxidant Activities of Fresh Juices from Romanian Cucurbitaceae Varieties." Molecules 25, no. 22: 5468.

Journal article
Published: 18 November 2020 in Processes
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Sweet sorghum is a unique bioenergy crop that produces stalks with fermentable free sugars. The purpose of this study was to evaluate how the production of hemicellulosic saccharides and bioethanol from sweet sorghum stalks (SSS) can be influenced by a dilute sulfuric acid (H2SO4) pretreatment under different isothermal conditions. The bioethanol production from untreated SSS and pretreated solid phases was achieved through the Simultaneous Saccharification and Fermentation (SSF) process. A good SSS fractionation and an extensive hemicellulose hydrolysis into soluble saccharides were obtained, the most abundant hemicellulose-derived compounds present in the pretreated liquid phase being monosaccharides, with up to 17.22 g/L of glucose and 16.64 g/L of xylose in the pretreatments performed with 3% and 1% H2SO4 for 30 min at 134 °C, respectively. The SSF process of untreated SSS allowed a maximum bioethanol concentration of 9.78 g/L, corresponding to a maximum glucan conversion into ethanol of 49.8%. Bioethanol production from untreated SSS led to a higher bioethanol concentration and conversion than in the case of using acid pretreated solid phases obtained under the most severe conditions (with 3% H2SO4 for 30, 60 and 120 min at 134 °C), suggesting that, in the case of this biomass naturally rich in soluble sugars, the acidic pretreatment could negatively influence the fermentative process.

ACS Style

Cristian-Teodor Buruiană; Luminița Georgescu; Simona-Florina Isticioaia; Oana Emilia Constantin; Camelia Vizireanu; Rodica Mihaela Dinică; Bianca Furdui. Insights on Monosaccharides and Bioethanol Production from Sweet Sorghum Stalks Using Dilute Acid Pretreatment. Processes 2020, 8, 1486 .

AMA Style

Cristian-Teodor Buruiană, Luminița Georgescu, Simona-Florina Isticioaia, Oana Emilia Constantin, Camelia Vizireanu, Rodica Mihaela Dinică, Bianca Furdui. Insights on Monosaccharides and Bioethanol Production from Sweet Sorghum Stalks Using Dilute Acid Pretreatment. Processes. 2020; 8 (11):1486.

Chicago/Turabian Style

Cristian-Teodor Buruiană; Luminița Georgescu; Simona-Florina Isticioaia; Oana Emilia Constantin; Camelia Vizireanu; Rodica Mihaela Dinică; Bianca Furdui. 2020. "Insights on Monosaccharides and Bioethanol Production from Sweet Sorghum Stalks Using Dilute Acid Pretreatment." Processes 8, no. 11: 1486.

Journal article
Published: 07 October 2020 in Molecules
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Basil (Ocimum spp.) is a traditional herbal medicine abundant in antioxidants such as phenolic compounds. As part of a diet, this herb is proved to have some roles in decreasing the risk of cancer, and in the treatment of inflammation and neurodegenerative diseases. This study aims to explore the total phenolic and flavonoid content of two new basil hybrids growing in Romania, namely “Aromat de Buzau” (AB) and “Macedon” (MB). The antioxidant capacity of those two species was also analyzed by DPPH and cyclic voltammetry. Six different flavonoids, such as catechin (+), rutin, hyperoside, naringin, naringenin, and genistein, were separated, identified, and quantified by HPLC–DAD chromatography, for the first time, from romanian basil hybrids. The main flavonoid of the extracts was found to be naringin which is present in the highest amount (26.18 mg/kg) in “Aromat de Buzau” (O. basilicum) methanolic extract. These results suggest that dietary intake of these new hybrids can be a source of antioxidant compounds.

ACS Style

Fanica Balanescu; Maria Mihaila; Geta Cârâc; Bianca Furdui; Costel Vînătoru; Sorin Avramescu; Elena Lisa; Mihaela Cudalbeanu; Rodica Dinica. Flavonoid Profiles of Two New Approved Romanian Ocimum Hybrids. Molecules 2020, 25, 4573 .

AMA Style

Fanica Balanescu, Maria Mihaila, Geta Cârâc, Bianca Furdui, Costel Vînătoru, Sorin Avramescu, Elena Lisa, Mihaela Cudalbeanu, Rodica Dinica. Flavonoid Profiles of Two New Approved Romanian Ocimum Hybrids. Molecules. 2020; 25 (19):4573.

Chicago/Turabian Style

Fanica Balanescu; Maria Mihaila; Geta Cârâc; Bianca Furdui; Costel Vînătoru; Sorin Avramescu; Elena Lisa; Mihaela Cudalbeanu; Rodica Dinica. 2020. "Flavonoid Profiles of Two New Approved Romanian Ocimum Hybrids." Molecules 25, no. 19: 4573.

Journal article
Published: 05 June 2020 in Catalysts
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A series of yeast strains was tested in order to evaluate their catalytic potential in biocatalysis of one-pot indolizine’s synthesis. Yeast cultivation was performed in a submerged system at 28 °C for 72 h at 180 rpm. An assessment of the reagents’ toxicity on yeast viability and metabolic functionality concluded that the growth potential of three Yarrowia lipolytica strains were least affected by the reactants compared to the other yeast strains. Further, crude fermentation products (biomass and cell-free supernatant)—obtained by submerged cultivation of these yeasts—were used in multistep cascade reactions for the production of fluorescent indolizine compounds with important biologic activities. A whole–cell catalyzed multicomponent reaction of activated alkynes, α-bromo-carbonyl reagents and 4,4′-bipyridine, at room temperature in buffer solution led to the efficient synthesis of bis-indolizines 4a, 4b and 4c, in good-to-excellent yields (47%–77%). The metabolites of the selected Y. lipolytica strains can be considered effective biocatalysts in cycloaddition reactions and the high purity and bioconversion yields of the synthesized indolizines indicates a great potential of this type of “green” catalysts. Seeds of Triticum estivum L. were used to investigate the impact of the final products on the germination and seedling growth. The most sensitive physiological parameters suggest that indolizines, at the concentrations tested, have non-toxic effect on germination and seedling growth of wheat, fact also confirmed by confocal laser scanning microscopy images.

ACS Style

Andreea Veronica Botezatu (Dediu); Georgiana Horincar; Ioana Otilia Ghinea; Bianca Furdui; Gabriela-Elena Bahrim; Vasilica Barbu; Fanica Balanescu; Lidia Favier; Rodica-Mihaela Dinica. Whole-Cells of Yarrowia lipolytica Applied in “One Pot” Indolizine Biosynthesis. Catalysts 2020, 10, 629 .

AMA Style

Andreea Veronica Botezatu (Dediu), Georgiana Horincar, Ioana Otilia Ghinea, Bianca Furdui, Gabriela-Elena Bahrim, Vasilica Barbu, Fanica Balanescu, Lidia Favier, Rodica-Mihaela Dinica. Whole-Cells of Yarrowia lipolytica Applied in “One Pot” Indolizine Biosynthesis. Catalysts. 2020; 10 (6):629.

Chicago/Turabian Style

Andreea Veronica Botezatu (Dediu); Georgiana Horincar; Ioana Otilia Ghinea; Bianca Furdui; Gabriela-Elena Bahrim; Vasilica Barbu; Fanica Balanescu; Lidia Favier; Rodica-Mihaela Dinica. 2020. "Whole-Cells of Yarrowia lipolytica Applied in “One Pot” Indolizine Biosynthesis." Catalysts 10, no. 6: 629.

Journal article
Published: 04 April 2020 in Foods
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Background: Momordica charantia Linn. (Cucurbitaceae), the wild variety of bitter melon and Morinda lucida Benth (Rubiaceae) were commonly used as a popular folk medicine in Benin. This research focused to measure the antioxidant and enzyme inhibitory effects of M. charantia and M. lucida leaves and their antidiabetic activity. Methods: Antioxidant activities were evaluated by micro-dilution technique using DPPH free radical scavenging activity and β-carotene-linoleate bleaching assay. The α-amylase inhibition assay was carried out utilizing the 3,5-dinitrosalicylic acid procedure, while β-glucosidase inhibition assay was demonstrated using as substrate p-nitrophenyl-β-D-glucopyranoside (PNPG). HPLC-DAD analysis was realized using a high-performance liquid chromatography systems with diode-array detector, L-3000. Results: Chlorogenic acid, epicatechin, daidzein, rutin, naringin, quercetin, naringenin and genistein were identified as polyphenol compounds in the both plants extract. Dichloromethane and ethyl acetate extracts showed a good α-amylase inhibitory activity (56.46 ± 1.96% and 58.76 ± 2.74% respectively). M. lucida methanolic extract has shown IC50 of 0.51 ± 0.01 mg/mL, which is the lowest for DPPH scavenging activity. M. lucida dichloromethane extract showed the highest inhibitory capacity of β-glucosidase activity (82.11. ± 2.15%). Conclusion: These results justify some traditional medicinal uses of both plants. The purified fractions could be used in future formulations, possibly incorporated in functional foods to combat certain diseases.

ACS Style

Michaelle Chokki; Mihaela Cudălbeanu; Cheikna Zongo; Durand Dah-Nouvlessounon; Ioana Otilia Ghinea; Bianca Furdui; Robert Raclea; Aly Savadogo; Lamine Baba-Moussa; Sorin Marius Avamescu; Rodica Mihaela Dinica; Farid Baba-Moussa; Mihaela Cudalbeanu. Exploring Antioxidant and Enzymes (A-Amylase and B-Glucosidase) Inhibitory Activity of Morinda lucida and Momordica charantia Leaves from Benin. Foods 2020, 9, 434 .

AMA Style

Michaelle Chokki, Mihaela Cudălbeanu, Cheikna Zongo, Durand Dah-Nouvlessounon, Ioana Otilia Ghinea, Bianca Furdui, Robert Raclea, Aly Savadogo, Lamine Baba-Moussa, Sorin Marius Avamescu, Rodica Mihaela Dinica, Farid Baba-Moussa, Mihaela Cudalbeanu. Exploring Antioxidant and Enzymes (A-Amylase and B-Glucosidase) Inhibitory Activity of Morinda lucida and Momordica charantia Leaves from Benin. Foods. 2020; 9 (4):434.

Chicago/Turabian Style

Michaelle Chokki; Mihaela Cudălbeanu; Cheikna Zongo; Durand Dah-Nouvlessounon; Ioana Otilia Ghinea; Bianca Furdui; Robert Raclea; Aly Savadogo; Lamine Baba-Moussa; Sorin Marius Avamescu; Rodica Mihaela Dinica; Farid Baba-Moussa; Mihaela Cudalbeanu. 2020. "Exploring Antioxidant and Enzymes (A-Amylase and B-Glucosidase) Inhibitory Activity of Morinda lucida and Momordica charantia Leaves from Benin." Foods 9, no. 4: 434.

Journal article
Published: 21 December 2019 in Antibiotics
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This study aimed to explore for the first time the biological properties such as antifungal, antitumoral and antioxidant of Danube Delta Nymphaea alba (N. alba) leaf and root methanolic extracts. The toxicity studies of N. alba extracts showed no inhibitory effect on wheat seed germination by evaluating the most sensitive physiological parameters (Germination %, Germination index, Vigor index) and using confocal laser scanning microscopy images. The analyzed extracts were found to have high antifungal activity against Candida glabrata with MIC values of 1.717 µg/mL for leaf and 1.935 µg/mL for root. The antitumor activity of the both extracts against A2780/A2780cisR ovarian, LNCaP prostate and MCF-7 breast cancer cells was promising with IC50 values ranging from 23–274 µg/mL for leaf and 18–152 µg/mL for root, and the combination of N. alba extracts with cisplatin showed a synergistic effect (coefficient of drug interaction

ACS Style

Mihaela Cudalbeanu; Bianca Furdui; Geta Cârâc; Vasilica Barbu; Alina Viorica Iancu; Fernanda Marques; Jorge Humberto Leitão; Sílvia Andreia Sousa; Rodica Mihaela Dinica; Mihaela Cudalbeanu. Antifungal, Antitumoral and Antioxidant Potential of the Danube Delta Nymphaea alba Extracts. Antibiotics 2019, 9, 7 .

AMA Style

Mihaela Cudalbeanu, Bianca Furdui, Geta Cârâc, Vasilica Barbu, Alina Viorica Iancu, Fernanda Marques, Jorge Humberto Leitão, Sílvia Andreia Sousa, Rodica Mihaela Dinica, Mihaela Cudalbeanu. Antifungal, Antitumoral and Antioxidant Potential of the Danube Delta Nymphaea alba Extracts. Antibiotics. 2019; 9 (1):7.

Chicago/Turabian Style

Mihaela Cudalbeanu; Bianca Furdui; Geta Cârâc; Vasilica Barbu; Alina Viorica Iancu; Fernanda Marques; Jorge Humberto Leitão; Sílvia Andreia Sousa; Rodica Mihaela Dinica; Mihaela Cudalbeanu. 2019. "Antifungal, Antitumoral and Antioxidant Potential of the Danube Delta Nymphaea alba Extracts." Antibiotics 9, no. 1: 7.

Journal article
Published: 15 October 2019 in Polymers
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In the last two decades, a tremendous amount of attention has been directed towards the design of antibacterial silver(I)-based materials, including coordination polymers (CPs) built up with a great variety of oxygen and nitrogen-containing ligands. Herein, a family of six new silver(I)-based CPs, having the general stoechiometric formula [Ag(H2DMPMB)(X)] (X = NO3, 1; CF3CO2, 2; CF3SO3, 3; BF4, 4; ClO4, 5; and PF6, 6) and incorporating the flexible ditopic pyrazolyl-type ligand 4,4'-bis((3,5-dimethyl-1H-pyrazol-4-yl)methyl)biphenyl (H2DMPMB), has been prepared by the chemical precipitation method involving the reaction of silver(I) salts with H2DMPMB in the 1:1 molar ratio, in alcohols, or acetonitrile at room temperature for two-hours. The new silver(I)-based polymeric materials were characterized by means of Fourier transform infrared spectroscopy (FTIR), elemental analysis (EA), and thermogravimetric analysis (TGA), allowing for the proposition that their structures comprise one-dimensional chains, with the silver(I) ions mostly assuming a T-shapped stereochemistry completed by the exo-bidentate ligands and counter-anions. The obtained silver(I) CPs showed a remarkable light insensitivity and stability in the air, are insoluble in water and in most common organic solvents, and possess appreciable thermal stabilities spanning the range 250-350 °C. The antibacterial activity of the obtained silver(I) CPs was tested against the Gram-negative bacteria Escherichia coli (E. coli) and Gram-positive bacteria Staphylococcus aureus (S. aureus) using the Tetrazolium/Formazan test (TTC), by measuring the bacterial viability at different time intervals. The complete reduction of both bacterial strains occurred after 24 h of exposure to all silver(I) CPs, the bacterial viability values for S. aureus reaching 8% for compounds 3, 5, and 6 after only two-hours.

ACS Style

Aurel Tăbăcaru; Claudio Pettinari; Mariana Bușilă; Rodica Mihaela Dinică. New Antibacterial Silver(I) Coordination Polymers Based on a Flexible Ditopic Pyrazolyl-Type Ligand. Polymers 2019, 11, 1686 .

AMA Style

Aurel Tăbăcaru, Claudio Pettinari, Mariana Bușilă, Rodica Mihaela Dinică. New Antibacterial Silver(I) Coordination Polymers Based on a Flexible Ditopic Pyrazolyl-Type Ligand. Polymers. 2019; 11 (10):1686.

Chicago/Turabian Style

Aurel Tăbăcaru; Claudio Pettinari; Mariana Bușilă; Rodica Mihaela Dinică. 2019. "New Antibacterial Silver(I) Coordination Polymers Based on a Flexible Ditopic Pyrazolyl-Type Ligand." Polymers 11, no. 10: 1686.

Journal article
Published: 28 July 2019 in Annals of the ”Dunarea de Jos” University of Galati. Fascicle II, Mathematics, Physics, Theoretical Mechanics
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The study of phenolic compounds remains an area of ​​the future because of the antiviral, anti-tumor, anti-inflammatory, anti-allergy, anti-cancer, healing, antiseptic and antioxidant properties they possess. The aim of our study was to evaluate the antioxidant activity and to evaluate the phytochemicals from the extracts (aqueous, hydroethanolic and ethanolic) of the leaves of Dischistocalyx hirsutus (Acanthaceae), a plant of the Congolese pharmacopeia. Our study showed the presence of several families, namely anthocyanins, flavonoids, tannins, cardiotonic heterosides and saponins. The presence of these different chemical families is more marked with the hydroethanolic extract. The TLC analysis by DPPH revealed the antioxidant potential of the extracts.

ACS Style

Gloria Stéphanie Aurélia Amboyi; Tsiba Gouollaly; Timoléon Andzi-Barhé; Rodica Mihaela Dinică; Mirela Praisler. Evaluation of TLC antioxidant activity and pytochemical screening of leaf extracts of Dischistocalyx Hirsutus C. B. Clarke. Annals of the ”Dunarea de Jos” University of Galati. Fascicle II, Mathematics, Physics, Theoretical Mechanics 2019, 42, 63 -67.

AMA Style

Gloria Stéphanie Aurélia Amboyi, Tsiba Gouollaly, Timoléon Andzi-Barhé, Rodica Mihaela Dinică, Mirela Praisler. Evaluation of TLC antioxidant activity and pytochemical screening of leaf extracts of Dischistocalyx Hirsutus C. B. Clarke. Annals of the ”Dunarea de Jos” University of Galati. Fascicle II, Mathematics, Physics, Theoretical Mechanics. 2019; 42 (1):63-67.

Chicago/Turabian Style

Gloria Stéphanie Aurélia Amboyi; Tsiba Gouollaly; Timoléon Andzi-Barhé; Rodica Mihaela Dinică; Mirela Praisler. 2019. "Evaluation of TLC antioxidant activity and pytochemical screening of leaf extracts of Dischistocalyx Hirsutus C. B. Clarke." Annals of the ”Dunarea de Jos” University of Galati. Fascicle II, Mathematics, Physics, Theoretical Mechanics 42, no. 1: 63-67.

Original article
Published: 02 July 2019 in International Microbiology
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This investigation was aimed to evaluate the antimicrobial activities and involvement of extracellular lytic enzymes produced by four strains of Trichoderma in the inhibition of Pythium myriotylum. Antagonistic effects were tested by dual culture. Activities of lytic enzymes were evaluated from the filtrate of each strain after cultivation in selected media. Organic extracts were obtained from liquid media subsequent to the cultivation of Trichoderma in potato dextrose broth (PDB). Non-volatile organic compounds such as polyphenols and flavonoids were evaluated spectrophotometrically while volatile organic compounds (VOCs) were analyzed by gas chromatography coupled with mass spectrometry (GC-MS). The antimicrobial activity of the organic extracts was determined using the poisoning method. Results have shown that all the strains were antagonists against P. myriotylum. T. erinaceum (IT-58), T. gamsii (IT-62), T. afroharzianum (P8), and T. harzianum (P11) that were found to produce cellulase, protease, and xylanase. Over 20 compounds were identified in each extract, including esters, lactones, and organic acids. The organic extracts also contained high amounts of polyphenolic compounds and flavonoids and significantly inhibited the mycelial growth of P. myriotylum. The minimal inhibition concentrations were 80 μg/μL, 40 μg/μL, 20 μg/μL, and 10 μg/μL, for extracts obtained from T. erinaceum (IT-58), T. gamsii (IT-62), T. afroharzianum (P8), and T. harzianum (P11), respectively. There was significant correlation between the production of total polyphenol and flavonoid content and the antagonistic effects of the tested strains.

ACS Style

Severin Nguemezi Tchameni; Mihaela Cotârleț; Ioana Otilia Ghinea; Marie Ampere Boat Bedine; Modeste Lambert Sameza; Daniela Borda; Gabriela Bahrim; Rodica Mihaela Dinică. Involvement of lytic enzymes and secondary metabolites produced by Trichoderma spp. in the biological control of Pythium myriotylum. International Microbiology 2019, 23, 179 -188.

AMA Style

Severin Nguemezi Tchameni, Mihaela Cotârleț, Ioana Otilia Ghinea, Marie Ampere Boat Bedine, Modeste Lambert Sameza, Daniela Borda, Gabriela Bahrim, Rodica Mihaela Dinică. Involvement of lytic enzymes and secondary metabolites produced by Trichoderma spp. in the biological control of Pythium myriotylum. International Microbiology. 2019; 23 (2):179-188.

Chicago/Turabian Style

Severin Nguemezi Tchameni; Mihaela Cotârleț; Ioana Otilia Ghinea; Marie Ampere Boat Bedine; Modeste Lambert Sameza; Daniela Borda; Gabriela Bahrim; Rodica Mihaela Dinică. 2019. "Involvement of lytic enzymes and secondary metabolites produced by Trichoderma spp. in the biological control of Pythium myriotylum." International Microbiology 23, no. 2: 179-188.

Journal article
Published: 01 July 2019 in Molecules
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A family of fifteen quaternary ammonium salts (QAs), bearing the 1,2-bis(4-pyridyl)ethane core, were obtained using for the first time two different green methods, such as microwave (MW) and ultrasounds (US) irradiation, with very good yields and in much shorter times compared to the classical method, and an assay on their antimicrobial action against Escherichia coli (E. coli) was carried out. While 12 to 24 hours were required for complete alkylation of 1,2-bis(4-pyridyl)ethane by reactive halogenated derivatives in anhydrous solvent under reflux conditions, MW and US irradiation reduced the reaction time and the desired products were achieved in a few min. One of the aims of this study was to evaluate the antibacterial potential of the synthesized QAs against pathogenic bacteria, along with their impact on germination activity of wheat seeds (Triticum aestivum L.). The antibacterial activity of the QAs against Escherichia coli was explored by determining the minimum inhibitory concentration (MIC). The MIC values varied from 0.312 to 2.5 mg/mL, highlighting the lowest values attained for the derivatives containing methoxy, chlorine and benzofurane functional groups. The viability of aerobic bacteria was determined with the Tetrazolium/Formazan Test, a method that was found to be the best alternative approach with respect to the difuzimetric method. Seeds of Triticum aestivum L. were used for the evaluation of the germination indicators, such as seed germination (SG), the relative seed germination (RSG), the relative radicle growth (RRG), and the seed germination index (GI). The toxicity studies of QAs 1, 4 and 7, at two different concentrations, showed no inhibitory effect on seed germination.

ACS Style

Aurel Tăbăcaru; Andreea Veronica Dediu Botezatu; Georgiana Horincar; Bianca Furdui; Rodica Mihaela Dinică. Green Accelerated Synthesis, Antimicrobial Activity and Seed Germination Test of Quaternary Ammonium Salts of 1,2-bis(4-pyridyl)ethane. Molecules 2019, 24, 2424 .

AMA Style

Aurel Tăbăcaru, Andreea Veronica Dediu Botezatu, Georgiana Horincar, Bianca Furdui, Rodica Mihaela Dinică. Green Accelerated Synthesis, Antimicrobial Activity and Seed Germination Test of Quaternary Ammonium Salts of 1,2-bis(4-pyridyl)ethane. Molecules. 2019; 24 (13):2424.

Chicago/Turabian Style

Aurel Tăbăcaru; Andreea Veronica Dediu Botezatu; Georgiana Horincar; Bianca Furdui; Rodica Mihaela Dinică. 2019. "Green Accelerated Synthesis, Antimicrobial Activity and Seed Germination Test of Quaternary Ammonium Salts of 1,2-bis(4-pyridyl)ethane." Molecules 24, no. 13: 2424.

Journal article
Published: 27 June 2019 in Materials
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The comparative effect of two quaternary ammonium salts from 1,2-bis(4-pyridyl)ethane (PyQAs), namely N,N′-diphenacyl-1,2-bis(4-pyridinium)ethane dibromide (PyQAs1) and N,N′-di(p-methoxyphenacyl)-1,2-bis(4-pyridinium)ethane dibromide (PyQAs2), upon the size and photoluminescence of zinc oxide nanoparticles (ZnO NPs) was investigated. The formation of ZnO NPs took place in the presence of variable amounts of the two PyQAs species (1, 2.5, and 5%), according to the chemical precipitation of zinc(II) acetate with potassium hydroxide in ethanol under reflux. The obtained ZnO NPs were structurally characterized by means of X-ray powder diffraction, infrared, and Raman spectroscopy. The fluorescence of all supernatant solutions, observed under ultraviolet light, determined us to make an investigation of the solutions by means of liquid chromatography coupled with electrospray ionization mass spectrometry (LC-MS-ESI) in order to elucidate the identity of the newly formed fluorescent species. Such an occurrence thus allowed the invocation of the catalytic effect of zinc(II) ions towards the organic transformation of both nonfluorescent PyQAs surfactants into new fluorescent organic species.

ACS Style

Aurel Tăbăcaru; Rodica Mihaela Dinică; Mihaela Cudălbeanu; Cristina Mihaela Nicolescu; Marius Bumbac; Mihaela Cudalbeanu. Catalytic Effect of Photoluminescent Zinc Oxide Nanoparticles Formed in the Presence of Quaternary Ammonium Salts. Materials 2019, 12, 2066 .

AMA Style

Aurel Tăbăcaru, Rodica Mihaela Dinică, Mihaela Cudălbeanu, Cristina Mihaela Nicolescu, Marius Bumbac, Mihaela Cudalbeanu. Catalytic Effect of Photoluminescent Zinc Oxide Nanoparticles Formed in the Presence of Quaternary Ammonium Salts. Materials. 2019; 12 (13):2066.

Chicago/Turabian Style

Aurel Tăbăcaru; Rodica Mihaela Dinică; Mihaela Cudălbeanu; Cristina Mihaela Nicolescu; Marius Bumbac; Mihaela Cudalbeanu. 2019. "Catalytic Effect of Photoluminescent Zinc Oxide Nanoparticles Formed in the Presence of Quaternary Ammonium Salts." Materials 12, no. 13: 2066.

Journal article
Published: 01 August 2018 in Inorganica Chimica Acta
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Two new dinuclear lanthanide(III) complexes, La-DPY and Nd-DPY, with the stoichiometric formula [{Ln(Et3N)(SO4)}2(μ-DPY)(μ4-SO4)] (Ln = La, Nd; DPY = ylide form of DPB, Et3N = triethylamine), were obtained through the reaction of N-heterocylic diquaternary salt N,N’-diphenacyl-4,4′-dipyridinium dibromide (DPB) and lanthanide(III) sulfate in methanol, in the presence of triethylamine. The obtained complexes were characterized by Fourier transform infrared spectroscopy, proton nuclear magnetic resonance, elemental analysis, UV–vis spectroscopy, thermogravimetric analysis and powder X-ray diffraction. Scanning electron microscopy (SEM) was used to investigate the morphology and particles size of the complexes, confirming that their particles are quite homogenous and uniform. The antitumor activity of the complexes was evaluated in the human cancer cells MCF7 and A2780 and compared to cisplatin, the metal-based drug in cancer therapy. The complexes were found to induce apoptotic cell death and, to a lesser extent, production of ROS, although these are not the unique mechanisms of action. In conclusion, we anticipate that these types of Ln(III) complexes have potential and could be further explored for applications as antitumor agents.

ACS Style

Andreea Cârâc; Rica Boscencu; Rodica Mihaela Dinică; Joana F. Guerreiro; Francisco Silva; Fernanda Marques; Maria Paula Cabral Campello; Călin Moise; Oana Brîncoveanu; Marius Enăchescu; Geta Cârâc; Aurel Tăbăcaru. Synthesis, characterization and antitumor activity of two new dipyridinium ylide based lanthanide(III) complexes. Inorganica Chimica Acta 2018, 480, 83 -90.

AMA Style

Andreea Cârâc, Rica Boscencu, Rodica Mihaela Dinică, Joana F. Guerreiro, Francisco Silva, Fernanda Marques, Maria Paula Cabral Campello, Călin Moise, Oana Brîncoveanu, Marius Enăchescu, Geta Cârâc, Aurel Tăbăcaru. Synthesis, characterization and antitumor activity of two new dipyridinium ylide based lanthanide(III) complexes. Inorganica Chimica Acta. 2018; 480 ():83-90.

Chicago/Turabian Style

Andreea Cârâc; Rica Boscencu; Rodica Mihaela Dinică; Joana F. Guerreiro; Francisco Silva; Fernanda Marques; Maria Paula Cabral Campello; Călin Moise; Oana Brîncoveanu; Marius Enăchescu; Geta Cârâc; Aurel Tăbăcaru. 2018. "Synthesis, characterization and antitumor activity of two new dipyridinium ylide based lanthanide(III) complexes." Inorganica Chimica Acta 480, no. : 83-90.

Journal article
Published: 23 May 2018 in Molecules
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Nymphaea alba is an aquatic flowering plant from the Nymphaeaceae family that has been used for hundreds of years in traditional herbal medicine. The plant is characterized by different phytochemicals, depending on the geographical location. Herein, we have carried out, for the first time, the separation and HPLC-MS/MS identification of some antioxidant compounds, such as polyphenols and flavonoids from N. alba extracts from the Danube Delta Biosphere, and investigated their possible antiradical properties. An ultrasonic method has been exhaustively used for the extraction of the antioxidant compounds from the different anatomic parts of N. alba (fruit, flower, leaf, stem, and root). The extracts that were obtained using ultrasound irradiation showed a large polyphenol (19.42 mg EqGA/100 mg extract) and flavonoid (0.97 mg EqQ/100 mg extract) content. The fruit and flower extracts showed the highest antioxidant activity index (AAI). Among the 27 phytochemical compounds identified in all of the N. alba extracts, rutin and p-coumaric acid were found as the major components. The content of macroelements and microelements in N. alba extracts were compared, and it was found that their concentrations depend on the different anatomic parts of the plant. This research contributes to the study of Nymphaeaceae family, being the first exhaustive phytochemical study of N. alba from a wild population in Romania.

ACS Style

Mihaela Cudalbeanu; Ioana Otilia Ghinea; Bianca Furdui; Durand Dah-Nouvlessounon; Robert Raclea; Teodor Costache; Iulia Elena Cucolea; Florentina Urlan; Rodica Mihaela Dinica; Mihaela Cudalbeanu. Exploring New Antioxidant and Mineral Compounds from Nymphaea alba Wild-Grown in Danube Delta Biosphere. Molecules 2018, 23, 1247 .

AMA Style

Mihaela Cudalbeanu, Ioana Otilia Ghinea, Bianca Furdui, Durand Dah-Nouvlessounon, Robert Raclea, Teodor Costache, Iulia Elena Cucolea, Florentina Urlan, Rodica Mihaela Dinica, Mihaela Cudalbeanu. Exploring New Antioxidant and Mineral Compounds from Nymphaea alba Wild-Grown in Danube Delta Biosphere. Molecules. 2018; 23 (6):1247.

Chicago/Turabian Style

Mihaela Cudalbeanu; Ioana Otilia Ghinea; Bianca Furdui; Durand Dah-Nouvlessounon; Robert Raclea; Teodor Costache; Iulia Elena Cucolea; Florentina Urlan; Rodica Mihaela Dinica; Mihaela Cudalbeanu. 2018. "Exploring New Antioxidant and Mineral Compounds from Nymphaea alba Wild-Grown in Danube Delta Biosphere." Molecules 23, no. 6: 1247.

Review article
Published: 20 July 2016 in Inorganica Chimica Acta
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The recent advances of click chemistry reactions have shown that catalysts based on Cu(I) ions and nanoparticles have the potential to mediate and activate the alkyne-azide cycloaddition reactions in mild conditions and with remarkable yields. This review is focused on the recent progress recorded, over the last five years, by the transition metal catalysts in the development of novel methods and applications in the field of click chemistry reactions. Their catalytic efficiency, along with their different applications in materials, drug discovery and biological environments are also presented.

ACS Style

Aurel Tăbăcaru; Bianca Furdui; Ioana Otilia Ghinea; Geta Cârâc; Rodica Mihaela Dinică. Recent advances in click chemistry reactions mediated by transition metal based systems. Inorganica Chimica Acta 2016, 455, 329 -349.

AMA Style

Aurel Tăbăcaru, Bianca Furdui, Ioana Otilia Ghinea, Geta Cârâc, Rodica Mihaela Dinică. Recent advances in click chemistry reactions mediated by transition metal based systems. Inorganica Chimica Acta. 2016; 455 ():329-349.

Chicago/Turabian Style

Aurel Tăbăcaru; Bianca Furdui; Ioana Otilia Ghinea; Geta Cârâc; Rodica Mihaela Dinică. 2016. "Recent advances in click chemistry reactions mediated by transition metal based systems." Inorganica Chimica Acta 455, no. : 329-349.

Journal article
Published: 10 March 2016 in Molecules
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The cycloaddition of pyridinium ylides with alkynes was investigated under mild conditions. A series of 13 pyridinium salts was prepared by alkylation of 4-substituted pyridines. Their reactivity with propiolic ester or amide in various reaction conditions (different temperatures, solvents, added bases) was studied, and 11 indolizines, with three points of structural variation, were, thus, isolated and characterized. The highest yields were obtained when electron-withdrawing groups were present on both the pyridinium ylide, generated in situ from the corresponding pyridinium salt, and the alkyne (X, Z = ester, amide, CN, carbonyl, etc.). Electron-withdrawing substituents, lowering the acid dissociation constant (pKa) of the pyridinium salts, allow the cycloaddition to proceed at pH 7.5 in aqueous buffers at room temperature.

ACS Style

Simon Bonte; Ioana Otilia Ghinea; Rodica Dinica; Isabelle Baussanne; Martine Demeunynck. Investigation of the Pyridinium Ylide—Alkyne Cycloaddition as a Fluorogenic Coupling Reaction. Molecules 2016, 21, 332 .

AMA Style

Simon Bonte, Ioana Otilia Ghinea, Rodica Dinica, Isabelle Baussanne, Martine Demeunynck. Investigation of the Pyridinium Ylide—Alkyne Cycloaddition as a Fluorogenic Coupling Reaction. Molecules. 2016; 21 (3):332.

Chicago/Turabian Style

Simon Bonte; Ioana Otilia Ghinea; Rodica Dinica; Isabelle Baussanne; Martine Demeunynck. 2016. "Investigation of the Pyridinium Ylide—Alkyne Cycloaddition as a Fluorogenic Coupling Reaction." Molecules 21, no. 3: 332.

Journal article
Published: 01 August 2015 in Journal of Biotechnology
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Georgiana Horincar; Ioana Otilia Ghinea; Bianca Furdui; Andreea Veronica Dediu; Gabriela Bahrim; Rodica Mihaela Dinica. Evaluation of the biologic activity of some quaternary ammonium salts against non-pathogenic and pathogenic microorganisms. Journal of Biotechnology 2015, 208, S104 .

AMA Style

Georgiana Horincar, Ioana Otilia Ghinea, Bianca Furdui, Andreea Veronica Dediu, Gabriela Bahrim, Rodica Mihaela Dinica. Evaluation of the biologic activity of some quaternary ammonium salts against non-pathogenic and pathogenic microorganisms. Journal of Biotechnology. 2015; 208 ():S104.

Chicago/Turabian Style

Georgiana Horincar; Ioana Otilia Ghinea; Bianca Furdui; Andreea Veronica Dediu; Gabriela Bahrim; Rodica Mihaela Dinica. 2015. "Evaluation of the biologic activity of some quaternary ammonium salts against non-pathogenic and pathogenic microorganisms." Journal of Biotechnology 208, no. : S104.

Journal article
Published: 01 August 2015 in Journal of Biotechnology
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Ioana Otilia Ghinea; Andreea Veronica Dediu; Claudia Ungureanu; Bianca Furdui; Gabriela Bahrim; Rodica Mihaela Dinica. Measuring the cytotoxicity of bioactive N-heterocyclic compounds obtained via enzymatic catalysis. Journal of Biotechnology 2015, 208, S28 -S29.

AMA Style

Ioana Otilia Ghinea, Andreea Veronica Dediu, Claudia Ungureanu, Bianca Furdui, Gabriela Bahrim, Rodica Mihaela Dinica. Measuring the cytotoxicity of bioactive N-heterocyclic compounds obtained via enzymatic catalysis. Journal of Biotechnology. 2015; 208 ():S28-S29.

Chicago/Turabian Style

Ioana Otilia Ghinea; Andreea Veronica Dediu; Claudia Ungureanu; Bianca Furdui; Gabriela Bahrim; Rodica Mihaela Dinica. 2015. "Measuring the cytotoxicity of bioactive N-heterocyclic compounds obtained via enzymatic catalysis." Journal of Biotechnology 208, no. : S28-S29.