Quercitrin (quercetin 3-O-α-L-rhamnopyranoside), one of the constituents of the biologically active aqueous extract obtained from Kalanchoe pinnata, is demonstrated to be a potent antileishmanial compound (IC50 ≈ 1 μg/mL) with a low toxicity profile. This is the first time that antileishmanial activity is demonstrated for a flavonoid glycoside.
1 December 2008 in International Immunopharmacology
The infusion of aerial parts (EI) of Eleusine indica Gaertn (Poaceae) is used in Brazil against airway inflammatory processes like influenza and pneumonia. Pre-treatment with 400 mg/kg of crude extract inhibited 98 % of lung neutrophil recruitment in mice exposed to aerosols of lipopolysaccharide (LPS) from Gram-negative bacteria, in a dose-dependent manner. At 400 μg/kg, schaftoside (6-C-β-glucopyranosyl-8-C-α-arabinopyranosylapigenin) and vitexin (8-C-β-glucopyranosylapigenin), isolated from EI, inhibited 62 % and 80 % of lung neutrophil influx, respectively. These results may justify the popular use of E. indica against airway inflammatory processes.