Prof. Bruce Turnbull
University of Leeds, Leeds, UK
Professor of Biomolecular Chemistry at the University of Lee...
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Academic Career Length
32Years (1995-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications7 November 2003 in Journal of the American Chemical Society
Journal Article
Bruce TurnbullADAntonio Daranas
Antonio Daranas7 July 2005 in Accounts of Chemical Research
Journal Article
JBJovica D. Badjić
Jovica D. Badjić
ANAlshakim Nelson
Alshakim Nelson
SCStuart J. Cantrill
Stuart J. CantrillBruce TurnbullJSJ. Fraser Stoddart
J. Fraser Stoddart
19 December 2012 in Chemical Society Reviews
Journal Article
ABAnna Bernardi
Anna Bernardi
Jesus Jimenez-BarberoACAlessandro Casnati
Alessandro Casnati
Cristina De CastroTDTamis Darbre
Tamis Darbre
AIAnne Imberty
Anne Imberty +27
Multivalency plays a major role in biological processes and particularly in the relationship between pathogenic microorganisms and their host that involves protein–glycan recognition. These interactions occur during the first steps of infection, for specific recognition between host and bacteria, but also at different stages of the immune response. The search for high-affinity ligands for studying such interactions involves the combination of carbohydrate head groups with different scaffolds and linkers generating multivalent glycocompounds with controlled spatial and topology parameters. By interfering with pathogen adhesion, such glycocompounds including glycopolymers, glycoclusters, glycodendrimers and glyconanoparticles have the potential to improve or replace antibiotic treatments that are now subverted by resistance. Multivalent glycoconjugates have also been used for stimulating the innate and adaptive immune systems, for example with carbohydrate-based vaccines. Bacteria present on their surfaces natural multivalent glycoconjugates such as lipopolysaccharides and S-layers that can also be exploited or targeted in anti-infectious strategies.
1 May 2002 in Reviews in Molecular Biotechnology
Journal Article
Bruce TurnbullJSJ.Fraser Stoddart
J.Fraser Stoddart
13 January 2004 in Journal of the American Chemical Society
Journal Article
13 August 2012 in Angewandte Chemie International Edition
Journal Article
DWDaniel J. Williamson
Daniel J. Williamson
MFMartin A. Fascione
Martin A. FascioneMWMichael A. Webb
Michael A. WebbBruce Turnbull“Sorting out” N-terminal labeling: The reversibility of transpeptidase reactions makes protein N-terminal labeling challenging. Depsipeptide substrates for sortase A release alcohol by-products, which are poor nucleophiles for the reverse reaction, during ligation. Proteins with an unhindered N-terminal glycine residue can be labeled efficiently with only a minimal excess of the labeling reagent (see scheme).
About Me
1. Danielewicz N, Rosato F, Dai W, Römer W, Turnbull WB, Mairhofer J. 2022. Microbial carbohydrate-binding toxins – From etiology to biotechnological application. Biotechnol Adv 59:107951.
2. Balmforth MR, Haigh J, Kumar V, Dai W, Tiede C, Tomlinson DC, Deuchars J, Webb ME, Turnbull WB. 2021. Piggybacking on the Cholera Toxin: Identification of a CTB-Binding Protein as an Approach for Targeted Delivery of Proteins to Motor Neurons. Bioconjug Chem 32:2205–2212.
2. Haigh JL, Williamson DJ, Poole E, Zhou D, Webb ME, Deuchars SA, Turnbull WB, Deuchars J. 2020. A versatile cholera toxin conjugate for neuronal targeting and tracing 6098–6101.
3. Wehrum, S., Williamson, D. J., Siukstaite, Branson, T. R., Sych, T., Madl, J., Wildsmith, G. C., Dai W, James, F. R., Maren, T., Webb, M. E., Römer, W., and Turnbull WB. 2021. Membrane fusion mediated by non-covalent binding of re-engineered cholera toxin assemblies to glycolipids. ChemRxiv 1–10.
4. Turnbull WB, Precious BL, Homans SW. 2004. Dissecting the Cholera Toxin - Ganglioside GM1 Interaction by Isothermal Titration Calorimetry 165–171.
5. Ross JF, Wildsmith GC, Johnson M, Hurdiss DL, Hollingsworth K, Thompson RF, Mosayebi M, Trinh CH, Paci E, Pearson AR, Webb ME, Turnbull WB. 2019. Directed Assembly of Homopentameric Cholera Toxin B-Subunit Proteins into Higher-Order Structures Using Coiled-Coil Appendages. J Am Chem Soc2019/03/12. 141:5211–5219.