After earning his PhD in Chemical Engineering at the University of Twente in 2000, van Sint Annaland joined the Fundamentals of Chemical Reaction Engineering research group there, starting as an Assistant Professor and later becoming an Associate Professor. In 2010, he became a Full Professor at Eindhoven University of Technology, heading the Chemical Process Intensification research group. In 2020, he also became the Scientific Director of the post-master's Process and Product Design course at the same university.
His research focuses on developing innovative multi-functional reactors using advanced, experimentally validated models. Key areas include integrating reaction and separation processes (e.g., membrane reactors, chemical looping and sorption-enhanced processes), dynamic heat exchange in reactors and electrifying chemical reactors, particularly via direct Joule heating and inductive heating.