Differences in the relative volumes of prostate gland components having distinct diffusivities, rather than changes in the conventionally cited “cellularity” metrics, are likely to be the major contributor to clinically observed variations of apparent diffusion coefficient in prostate tissue. PurposeTo investigate the hypothesis that the clinically observed decrease in apparent diffusion coefficient (ADC) at diffusion-weighted magnetic resonance imaging with increasing prostate cancer Gleason grade can be attributed to an increasing volume of low-diffusivity epithelial cells and corresponding decreasing volumes of higher-diffusivity stroma and lumen space rather than to increased cell density.Materials and MethodsTissue samples were acquired after institutional ethics review committee approval and informed consent from patients were obtained. Nuclear count, nuclear area, and gland component volumes (epithelium, stroma, lumen space) were measured in tissue from 14 patients. Gland component volumes and cellularity metrics were correlated with Gleason pattern (Spearman rank correlation coefficient) and measured ADC (Pearson correlation coefficient) in six prostates ex vivo. Differences between metrics for cancerous tissue and those for normal tissue were assessed by using a two-tailed two-sample ...

To propose Irish CT diagnostic reference levels (DRLs) by collecting radiation doses for the most commonly performed CT examinations. A pilot study investigated the most frequent CT examinations. 40 CT sites were then asked to complete a survey booklet to allow the recording of CT parameters for each of 9 CT examinations during a 12-week period. Dose data [CT volume index (CTDI(vol)) and dose-length product (DLP)] on a minimum of 10 average-sized patients in each category were recorded to calculate a mean site CTDI(vol) and DLP value. The rounded 75th percentile was used to calculate a DRL for each site and the country by compiling all results. are compared with international DRL data. Results Data were collected for 3305 patients. 30 sites responded with data for 34 scanners, representing 54% of the national total. All equipment had multislice capability (2-128 slices). DRLs are proposed using CTDI(vol) (mGy) and DLP (mGy cm) for CT head (66/58 and 940, respectively), sinuses (16 and 210, respectively), cervical spine (19 and 420, respectively), thorax (9/11 and 390, respectively), high resolution CT (7 and 280, respectively), CT pulmonary angiography (13 and 430, respectively), multiphase abdomen (13 and 1120, respectively), routine abdomen/pelvis (12 and 600, respectively) and trunk examinations (10/12 and 850, respectively). These values are lower than current DRLs and comparable to other international studies. Wide variations in mean doses are noted across sites. Baseline figures for Irish CT DRLs are provided on the most frequently performed CT examinations. The variations in dose between CT departments as well as between identical scanners suggest a large potential for optimisation of examinations.

OBJECTIVE. The aim of the work was to establish optimum ambient light conditions for viewing radiologic images of the wrist on liquid crystal display monitors.MATERIALS AND METHODS. Five ambient light levels were investigated: 480, 100, 40, 25, and 7 lux. Seventy-nine experienced radiologists were asked to examine 30 posteroanterior wrist images and decide whether a fracture was present. All images were displayed on liquid crystal display monitors. Receiver operating characteristic analysis was performed, and the numbers of false-positive and false-negative findings were recorded.RESULTS. For all the radiologists, greater area under the receiver operating characteristic curve and lower numbers of false-positive and false-negative findings were recorded at 40 and 25 lux compared with 480 and 100 lux. At 7 lux, the results were generally similar to those at 480 and 100 lux. The experience and knowledge of radiologists specializing in imaging of musculoskeletal trauma appeared to compensate in part for inapp...

Purpose: To measure the effect of abnormality-prevalence expectation on experienced radiologists' performance during pulmonary nodular lesion detection on a chest radiograph. Materials and Methods: A multiobserver receiver operating characteristic (ROC) and eye-position analysis study was performed to assess the effect of prevalence expectation on observer performance. Twenty-two experienced radiologists were divided into three groups and each was asked to interpret 30 (15 abnormal) identical posteroanterior chest images twice and decide if pulmonary lesions were present. Before each viewing, the radiologists were told that the images contained a specific number of abnormal images: group 1: 9 and 15; group 2: 15 and 22; and group 3: 15 and not told. Results: ROC analysis demonstrated that no significant effect could be measured as a function of prevalence expectation (P > .05). However, eye-position analysis showed significant increases in eye movements at higher prevalence expectation rates in terms of the number of fixations per image (group 1: P = .0001; group 2: P = .0001; group 3: P = .001) and the total scrutiny time of each image (group 1: P = .0001; group 2: P = .0283; group 3: P = .028). Conclusion: Overall, findings of this study showed no evidence that the accuracy of expert radiologists is altered due to changing prevalence expectation rates. However, the time spent interpreting each image and the number of fixations increased at higher prevalence rates. Maintenance of diagnostic efficacy has been shown even when circumstances challenge normal observer behavior.

OBJECTIVE. Orthopedic injury and intracranial hemorrhage are commonly encountered in emergency radiology, and accurate and timely diagnosis is important. The purpose of this study was to determine whether the diagnostic accuracy of handheld computing devices is comparable to that of monitors that might be used in emergency teleconsultation.SUBJECTS AND METHODS. Two handheld devices, a Dell Axim personal digital assistant (PDA) and an Apple iPod Touch device, were studied. The diagnostic efficacy of each device was tested against that of secondary-class monitors (primary class being clinical workstation display) for each of two image types—posteroanterior wrist radiographs and slices from CT of the brain—yielding four separate observer performance studies. Participants read a bank of 30 wrist or brain images searching for a specific abnormality (distal radial fracture, fresh intracranial bleed) and rated their confidence in their decisions. A total of 168 readings by examining radiologists of the American ...