Accurate segmentation of lung cancer in pathology slides is a critical step in improving patient care. We proposed the ACDC@LungHP (Automatic Cancer Detection and Classification in Whole-slide Lung Histopathology) challenge for evaluating different computer-aided diagnosis (CADs) methods on the automatic diagnosis of lung cancer. The ACDC@LungHP 2019 focused on segmentation (pixel-wise detection) of cancer tissue in whole slide imaging (WSI), using an annotated dataset of 150 training images and 50 test images from 200 patients. This paper reviews this challenge and summarizes the top 10 submitted methods for lung cancer segmentation. All methods were evaluated using metrics using the precision, accuracy, sensitivity, specificity, and DICE coefficient (DC). The DC ranged from 0.7354±0.1149 to 0.8372±0.0858. The DC of the best method was close to the inter-observer agreement (0.8398±0.0890). All methods were based on deep learning and categorized into two groups: multi-model method and single model method. In general, multi-model methods were significantly better (p<0.01) than single model methods, with mean DC of 0.7966 and 0.7544, respectively. Deep learning based methods could potentially help pathologists find suspicious regions for further analysis of lung cancer in WSI.

Recently, unsupervised domain adaptation in satellite pose estimation has gained increasing attention, aiming at alleviating the annotation cost for training deep models. To this end, we propose a self-training framework based on the domain-agnostic geometrical constraints . Specifically, we train a neural network to predict the 2D keypoints of a satellite and then use PnP to estimate the pose. The poses of target samples are regarded as latent variables to formulate the task as a minimization problem. Furthermore, we leverage fine-grained segmentation to tackle the information loss issue caused by abstracting the satellite as sparse keypoints. Finally, we iteratively solve the minimization problem in two steps: pseudo-label generation and network training. Experimental results show that our method adapts well to the target domain. Moreover, our method won the 1st place on the sunlamp task of the second international Satellite Pose Estimation Competition.

Convolutional neural networks (CNNs) have been adopted in monocular satellite pose estimation and achieve superior performance over traditional methods. However, existing CNN-based methods suffer from bias toward texture, indirect description of absolute distance, and lack of long-range dependence modeling. Such factors limit the generalizability of CNN-based methods. Motivated by the striking achievements of transformer models, this article adopts transformer blocks for satellite pose estimation from a single RGB image, proposing an efficient monocular satellite pose estimation method. First, we design an effective satellite representation model based on a set of keypoints. Then, considering monocular satellite pose estimation characteristics, we construct an end-to-end keypoint-set prediction network and build the bipartite loss function. Further, we improve the backbone structure for high-quality feature extraction. Experimental results on a public benchmark dataset indicate that the proposed method achieves second and third place on the synthetic and real test sets, respectively, using only synthetic training data. We also demonstrate that our keypoint predictor takes half as much time as the first-placed method in our comparison, and therefore achieves a better tradeoff between speed and accuracy than existing approaches.

Bronchoscopy inspection, as a follow-up procedure next to the radiological imaging, plays a key role in the diagnosis and treatment design for lung disease patients. When performing bronchoscopy, doctors have to make a decision immediately whether to perform a biopsy. Because biopsies may cause uncontrollable and life-threatening bleeding of the lung tissue, thus doctors need to be selective with biopsies. In this paper, to help doctors to be more selective on biopsies and provide a second opinion on diagnosis, we propose a computer-aided diagnosis (CAD) system for lung diseases, including cancers and tuberculosis (TB). Based on transfer learning (TL), we propose a novel TL method on the top of DenseNet: sequential fine-tuning (SFT). Compared with traditional fine-tuning (FT) methods, our method achieves the best performance. In a data set of recruited 81 normal cases, 76 TB cases and 277 lung cancer cases, SFT provided an overall accuracy of 82% while other traditional TL methods achieved an accuracy from 70% to 74%. The detection accuracy of SFT for cancers, TB, and normal cases are 87%, 54%, and 91%, respectively. This indicates that the CAD system has the potential to improve lung disease diagnosis accuracy in bronchoscopy and it may be used to be more selective with biopsies.

In this article, we present four cases of minimal solutions for two-view relative pose estimation by exploiting the affine transformation between feature points, and we demonstrate efficient solvers for these cases. It is shown that under the planar motion assumption or with knowledge of a vertical direction, a single affine correspondence is sufficient to recover the relative camera pose. The four cases considered are two-view planar relative motion for calibrated cameras as a closed-form and least-squares solutions, a closed-form solution for unknown focal length, and the case of a known vertical direction. These algorithms can be used efficiently for outlier detection within a RANSAC loop and for initial motion estimation. All the methods are evaluated on both synthetic data and real-world datasets. The experimental results demonstrate that our methods outperform comparable state-of-the-art methods in accuracy with the benefit of a reduced number of needed RANSAC iterations. The source code is released at https://github.com/jizhaox/relative_pose_from_affine .