Our objective is to design triple-band implantable antennas with wide bandwidths and appropriate sizes for biomedical applications. The targeted design frequencies are 400 MHz, 2.4 GHz, and the new Wi-Fi band of 5.7 GHz. Three triple-band antennas with bandwidth improvements are presented to insure all-time data connection. The proposed triple-band implantable antennas benefit from combining long-distance data transfer at lower frequency bands and a higher effective bandwidth, and high-speed communications at higher frequency bands, which will have flexibility for a variety of applications. A comprehensive explanation of the design procedure to achieve multiple-band implantable antennas is provided. Furthermore, miniaturization techniques are utilized to design antennas in compact sizes suitable for biomedical applications. In this paper, three-layer structures including skin, fat, and muscle are used for the designs, then antennas are placed in the chest, neck, head, and hand of different human voxels to compare antennas’ performance. Additionally, normal and overweight human effects on antenna performance were compared. Antennas have 2 to 6 dBi directivity for telemetry usage, and they are designed to satisfy the absorption limit for the human body to keep the Specific Absorption Rate (SAR) averaged over 1 g of tissue less than 1.6 W/kg and over 10 g of tissue less than 2 W/kg, according to IEEE standard. The antennas include fractal, meandered, and comb types with sizes of 1.4 mm × 10 mm × 10 mm, 3.04 mm × 10 mm × 17.25 mm, and 1.4 mm × 12 mm × 12 mm, respectively. The designed antenna showed an impedance bandwidth of 53 MHz to 120 MHz, 90 MHz to 320 MHz, and 300 MHz to 1200 MHz at the three bands. The meandered antenna was selected for validation of simulations, and its S parameters were measured in the equivalent liquid phantom of body tissues.

An in-depth review on a new ultrasonic micro-droplet generator which utilizes megahertz (MHz) Faraday waves excited by silicon-based multiple Fourier horn ultrasonic nozzles (MFHUNs) and its potential applications is presented. The new droplet generator has demonstrated capability for producing micro droplets of controllable size and size distribution and desirable throughput at very low electrical drive power. For comparison, the serious deficiencies of current commercial droplet generators (nebulizers) and the other ultrasonic droplet generators explored in recent years are first discussed. The architecture, working principle, simulation, and design of the multiple Fourier horns (MFH) in resonance aimed at the amplified longitudinal vibration amplitude on the end face of nozzle tip, and the fabrication and characterization of the nozzles are then described in detail. Subsequently, a linear theory on the temporal instability of Faraday waves on a liquid layer resting on the planar end face of the MFHUN and the detailed experimental verifications are presented. The linear theory serves to elucidate the dynamics of droplet ejection from the free liquid surface and predict the vibration amplitude onset threshold for droplet ejection and the droplet diameters. A battery-run pocket-size clogging-free integrated micro droplet generator realized using the MFHUN is then described. The subsequent report on the successful nebulization of a variety of commercial pulmonary medicines against common diseases and on the experimental antidote solutions to cyanide poisoning using the new droplet generator serves to support its imminent application to inhalation drug delivery.

Electrodeposited iridium oxide (IrOx) pH sensors are gaining interest in numerous biomedical applications, attributed to their superior accuracy, straightforward fabrication, and compatibility with other microfabrication processes. However, the pH sensing range and stability of these sensors have been long-entrenched challenges to control. In this study, we explored the sensor’s behavior under pH conditions beyond its typical sensing range, unearthing potential correlations between the sensing range and other influential factors. Based on these findings, we proposed and implemented a practical method to manipulate the sensing range to designated pH regions. This methodology significantly expanded the sensor’s applicability to encompass extreme acidic or basic environments. A series of investigations revealed that, under such severe conditions, the sensor’s stability—as quantified by drift—could be enhanced more than tenfold posttreatment. Moreover, other stability metrics, including linearity and hysteresis, exhibited notable improvements through this technique, as validated by titration tests in the extended pH sensing ranges. This research offers meaningful insights and a promising approach to enhance the sensing range and stability of electrodeposited IrOx pH sensors, thereby potentially progressing their practical application in biomedical domains.