Background: Vitiligo is an autoimmune disease affecting approximately 2% of the world’s population. Besides vitiligo cosmetic issues, patients suffer from psychological comorbidities. This results from the stigmatization they encounter from surrounding individuals. Accordingly, the current study was the first to assess Jordanians’ knowledge and attitude toward vitiligo. Methods: Data collection was completed by an online questionnaire consisting of four sections to capture participants’ sociodemographic characteristics, previous exposure, and knowledge and attitude toward vitiligo. The analysis took place through R and RStudio. Results: Of our 994 surveyed participants, only 8.45% and 12.47% had a low level of vitiligo knowledge and negative total attitude score, respectively. Moreover, independent predictors of positive attitudes included younger age (18–30), high school education or lower, hearing about or living with a vitiligo patient, and higher knowledge scores. The highest prevalence of positive attitudes was observed when physicians were the source of knowledge. Conclusion: Some critical misconceptions were identified despite the Jordanian public having sufficient overall knowledge. Furthermore, higher knowledge reflected a higher prevalence of positive attitudes toward the patients. We recommend that future efforts target the public understanding of the nature of the disease and its being non-communicable. Moreover, we emphasize that medical knowledge should be communicated through qualified healthcare providers.

Choroid plexus papillomas are rare brain neoplasms, primarily observed in children, and typically manifest with symptoms indicative of heightened intracranial pressure and cerebral irritation. In addition, the tumor's localization varies with the patient's age, and diagnostic and therapeutic approaches predominantly rely on imaging findings and surgical interventions, with histopathological examination being essential for confirmation. This study outlines a unique instance of choroid plexus papilloma in a 30-year-old female, who presented with severe headache and vomiting, subsequently revealing hydrocephalus on Brain CT. Remarkably, the tumor was identified in the Foramen of Monro, an exceedingly rare and unreported location in adults. Notably, the patient underwent successful endoscopic resection without complications, a technique sparsely documented in similar cases. Choroid plexus papilloma, predominantly afflicting children, displays varied tumor locations depending on the patient's age. Our report highlights an exceptional case with an atypical tumor location that was not reported before to our knowledge, and addressed through an innovative endoscopic resection method that was recently used in the management of such cases. This underscores the importance of considering diverse tumor presentations, as it has a favorable prognosis achievable through management, especially with the increasing number of reported cases. Moreover, it advocates for the adoption of emerging endoscopic approaches, which exhibit promising outcomes.

Invasive extra-operative monitoring for drug-resistant epilepsy is primarily conducted using stereo-electroencephalography (SEEG) and subdural grids (SDG).

While fused deposition modelling (FDM) of polyether ether ketone (PEEK) has achieved regulatory acceptance and is utilized for patient-specific orthopaedic implants, the obligatory terminal sterilization via gamma irradiation raises concerns regarding polymer aging and structural degradation. This study investigates the spatiotemporal effects of gamma sterilization on the macroscopic mechanical integrity and medium-term in vivo biocompatibility of 3D-printed PEEK. Standard specimens were fabricated using a Taguchi L9 orthogonal array, manipulating key FDM parameters (layer thickness, print speed, number of shells, and raster width). To simulate a worst-case scenario of accelerated aging and free radical-induced degradation, specimens were subjected to 50 kGy of gamma irradiation and mechanically evaluated over a two-month period. In parallel, to assess clinical safety, an extensive in vivo study was conducted utilizing 81 BALB/c rats over 12 weeks. Specimens sterilized at the standard clinical dose of 25 kGy were implanted subcutaneously and compared with autoclaved controls. Mechanical testing revealed complex, nonlinear interactions between printing parameters and post-irradiation time, indicating simultaneous cross-linking and delayed oxidative chain scission mechanisms that ultimately preserved functional strength. Crucially, histological evaluation at 4, 8, and 12 weeks demonstrated excellent in vivo biocompatibility, characterized by minimal acute inflammation, rare foreign body giant cells, and the formation of a healthy, organized fibrous capsule, irrespective of the sterilization method. These findings suggest that 3D-printed PEEK maintains its structural resilience and favourable immunomodulatory profile post-gamma sterilization, successfully bridging the gap between additive manufacturing parameters and safe clinical translation.