Idiopathic pulmonary fibrosis is a poorly prognosed form of progressive interstitial pneumonia. Patients with IPF have a significantly increased risk of developing lung cancer, which further worsens the course of the disease. The most common histological types of LC among patients with IPF are squamous cell carcinoma and adenocarcinoma. Furthermore, all LC treatment modalities can lead to developing an acute IPF exacerbation. In this report, we present a rare case of coexistence of IPF and small cell lung cancer in a 76-year-old patient with chronic obstructive pulmonary disease, and a former smoker. For over 2 years, the patient was treated with an anti-fibrotic drug-pirfenidone, which slowed down the progression of IPF. Unfortunately, after being diagnosed with an active SCLC, the patient was excluded from further participation in the pirfenidone drug program. SCLC is characterized by high aggressiveness, rapid growth and high metastatic potential; therefore, it is necessary to apply antitumor treatment as soon as possible. The described patient was treated with carboplatin–etoposide chemotherapy. Early treatment tolerance was good and after two cycles of cytotoxic treatment, a partial response was present in CT. The presented case emphasizes the need for further research to determine the treatment regimens in patients with coexisting IPF and LC and the appropriateness of antifibrotic treatment in them. In addition, it can help to choose the treatment method for similar patients, indicating a combination of carboplatin and etoposide as an effective and, at the same time, relatively safes method in terms of the risk of IPF’s exacerbation.

Introduction and purpose: Celiac disease occurs in 1% of the general population. However, many cases remain unrecognized. The disease is a chronic immune-mediated disorder triggered by the ingestion of gluten that appears in individuals with genetic susceptibility. Celiac disease can develop in paediatric patients as well as adults. The purpose of this review is to analyze the newest information on the characteristics, diagnosis and treatment of patients with celiac disease. Material and methods: This review was based on available data collected in the PubMed database and published between 2015 and 2022. The research was done by looking through keywords such as: “celiac disease”, “Gluten-Free Diet”, “diagnosis” and “treatment”. Results: The diagnosis of celiac disease is most often delayed due to the broad spectrum of presentations. Screening of at-risk individuals is important to progress the diagnosis. It is additionally crucial to raise clinicians' attention to non-specific parenteral symptoms that may indicate celiac disease. The majority of the symptoms arise from nutritional deficiencies caused by intestinal malabsorption. According to scientific reports, the most common deficiencies of people with celiac disease are iron, folic acid, vitamin B12, fat-soluble vitamins and a calcium. Conclusions: Recent years have seen the emergence of research into new therapeutic options, but their efficacy and safety still need to be evaluated more thoroughly. Strict adherence to a gluten-free diet by patients is still the only treatment option at present. Celiac disease, due to the constant increase in knowledge about its pathogenesis, diagnosis and treatment is an important material for further research.

Introduction and purpose The fashion for following a gluten-free diet is causing more and more people to opt for it. It is indicated in the treatment of celiac disease. Due to the high prevalence of Hashimoto's disease in the population and the lack of causal treatment for the disease, many researchers have tested the validity of gluten elimination for those burdened with it. This work aimed to review the results achieved so far and assess whether this diet has a real impact on the course of Hashimoto's disease. A brief description of the state of knowledge A PubMed database was searched for studies describing the relationship between gluten consumption and the course of Hashimoto's disease. Some studies indicated a potential beneficial effect of the introduced diet on thyroid function. However, these were mostly survey-based studies of questionable research quality. More reliable studies that took into account antibody and TSH levels showed no significant improvement in thyroid function in response to the diet. Conclusions Based on the studies reviewed, there is no need for a gluten-free diet in patients with chronic autoimmune thyroid disease. It has not been proven that gluten can provoke the body to produce autoantibodies that cause the destruction of thyroid tissue. It is more important to maintain a balanced diet rich in zinc, selenium, iodine, vitamin D3, and iron, as they are essential in the process of hormone production by the thyroid gland.

Introduction: The efforts to restore lost collagen, regain youthful-looking skin and healthier joints have made collagen oral supplements a huge trend of the last few years. Because collagen is the main building protein of our body, many people may ask themselves - can collagen supplementation have a real impact on our health? Are these nutraceuticals a fountain of youth in a bottle or nothing more than marketing hype? The aim of the study: The aim of this paper was to present the current state of knowledge on the supplementation of collagen and application of collagen in oral nutraceuticals. Material and methods: Literature review available on PubMed, Science Direct and Google Scholar and evaluation of available randomized controlled trials using collagen supplementation in terms of treatment effectiveness in terms of skin quality, anti-aging benefits and potential use in dermatology. Abstracts, comments, and non-English language articles were excluded. Conclusions: Collagen is important for maintaining the structural integrity of every tissue in the body. Despite many studies on collagen supplementation, the literature is still impecunious, but the scientific works so far confirm that supplementation with hydrolyzed collagen can improve various aspects of skin aging. Key words: collagen, collagen peptides, antiaging, skin health, nutraceuticals

Polycystic ovary syndrome (PCOS) is a heterogeneous disorder in terms of clinical symptoms and laboratory findings. It is one of the most common endocrinopathies in women of childbearing age. The development of symptoms and the degree of severity in the course of the disease are the results of changes in the ovaries which may be caused by many genetic, metabolic, neuroendocrine, and environmental factors. The main clinical manifestations are menstrual disorders, difficulties with becoming pregnant, and changes related to hyperandrogenism, e.g., acne, hirsutism. Recognition is above mainly based on Rotterdam criteria.A comprehensive explanation of pathophysiology is still lacking. Nevertheless, it probably is a multifactorial condition with a genetic component. Women suffering from PCOS experience lipid and carbohydrate metabolism disorders, which lead to insulin resistance, obesity, hypertension, and cardiac complications. Insulin resistance affects 65-70% of women and not only plays a significant role in the development of the disease but also contributes to the development of hypertension and dyslipidemia. Potential mechanisms of hypertension in PCOS include endothelial dysfunction, increased aldosterone, and excess testosterone secretion, whereas lipid abnormalities consist of reduced high-density lipoprotein-cholesterol (HDL-C), increased triglycerides, and low-density lipoprotein-cholesterol (LDL-C). All of these factors cause high cardiovascular risk. Currently, therapy considers both lifestyle improvements and medications and must be tailored on a case-by-case basis. It is very important not to consider PCOS only in the context of gynecological and endocrine diseases, but also metabolic changes and cardiovascular diseases. Treatment of PCOS should be individualized and dependent on the predominant disorders, as well as the short- and long-term goals chosen. It also should take the prevention of cardiovascular diseases into account.

Introduction and purpose: The prevalence of cardiac arrhythmias in the population is not exactly known. Since cardiac arrhythmias are often episodic, they cannot be detected by conventional methods such as electrocardiography (ECG), which takes only a few seconds to record. The purpose of this review is to analyze the latest information regarding the use of smart watches to detect cardiac arrhythmias. Material and methods: This review is based on available data collected in the PubMed database published between 2015 and 2022. The search was performed by browsing keywords such as: "smartwatch", "cardiac arrhythmia", "mHealth", "screening", "wearable devices". Results: The results suggest that the detection of atrial fibrillation (AF) using commercially available smartwatches shows very high diagnostic accuracy. Accuracy in smartwatch arrhythmia detection demonstrated a cumulative sensitivity of 100% (95% CI 1.00-1.00) in 16 studies with 5,050 participants. Sensitivity ranged from 25% (95% CI 0.14-0.36) to 100% (95% CI 1.00-1.00), specificity ranged from 68% (95% CI 0.65 -0.70) to 100% (95% Cl 1.00-1.00). Insufficient quality of the PPG signal resulted in the exclusion of some data in many studies. The analyzes showed no difference in diagnostic accuracy between photoplethysmography (PPG) and single-lead electrocardiography used in these devices. Conclusions: The prevalence of arrhythmias in the form of atrial fibrillation and other forms of arrhythmia in the middle-aged and older population is significant. This review highlights the increasing role of electronic devices in the detection of cardiac arrhythmias. Smartwatches show promising accuracy in detecting arrhythmias, but more research is needed to make this method of arrhythmia recognition a common screening method.