In the last decade, several access cavity designs with minimal removal of tooth tissue have been described for gaining entry to pulp chambers during root canal treatment. The premise behind this concept assumes that maximum preservation of as much of the pulp chamber roof as possible during access preparation would maintain the fracture resistance of teeth following root canal treatment. However, the smaller the access cavity, the more difficult it may be to visualise and debride the pulp chamber as well as locate, shape, clean and fill the canals. At the same time, a small access cavity may increase the risk of iatrogenic complications as a result of poor visibility, which may negatively impact the treatment outcome. This study aimed to critically analyse the literature on minimal access cavity preparations, propose new nomenclature based on self‐explanatory abbreviations, and highlight the areas in which more research is required. The search was conducted without restrictions using specifics terms and descriptors in four databases. A complementary screening of the references within the selected studies, as well as a manual search in the highest impact journals in Endodontics, namely International Endodontic Journal and Journal of Endodontics, were also performed. The initial search retrieved 1,831 publications. The titles and abstracts of these papers were reviewed and the full text of 94 studies assessed. Finally, a total of 28 studies were identified as evaluating the influence of minimally invasive access cavity designs on the fracture resistance of teeth and at different stages of root canal treatment (orifice location, canal shaping, canal cleaning, canal filling and retreatment). Overall, the studies had major methodological drawbacks and reported inadequate and/or inconclusive results on the utility of minimally invasive access preparations. Furthermore, they offered limited scientific evidence to support the use of minimally invasive access cavities to improve the outcome of root canal treatment and retreatment, as well as, to preserve the fracture resistance of root filled teeth to a greater extent than traditional access cavity preparations. It was concluded that, at present, there is a lack of supporting‐evidence for the introduction of minimally invasive access cavity preparation into routine clinical practice and/or training of undergraduate and postgraduate students.