Released agent is a supramolecular system formed around nanobubbles in highly diluted solutions of substances subjected to technological processing. Released agent retains the structure and symmetry of the supramolecular system of the dissolved substance. It has two specific properties: (1) when combined with the original substance, it modifies its effect on an organism; (2) and it could cause an atypical pathological reaction in some individuals. These properties could be due to the transmission of symmetry from released agent to the receptor in the molecular recognition reaction by deforming the receptor structure. A theoretical analysis of these properties was carried out using methods of statistical thermodynamics of complex systems, chemical thermodynamics of supramolecular systems, and analytical mechanics. The released agent’s modifying effect is a phenomenon of the receptor pre-organization in the molecular recognition reaction. The selective ability and free energy of complex formation of released agent (from highly diluted antibodies to the beta-subunit of the insulin receptor) with the insulin receptor was evaluated. The atypical pathological reaction of some individuals to released agents resembles a resonance phenomenon that occurs when the symmetries (structures) of released agent and the receptor coincide. The obtained results show a possibility to investigate released agents’ properties not only empirically, but also using the methods of theoretical physics.

Aqueous solutions are not homogeneous and could be considered supramolecular systems. They can emit electromagnetic waves. Electromagnetic emission from one supramolecular system (“source”) can be received by another supramolecular system (“receiver”) without direct contact (distantly). This process represents a transfer of a “molecular signal” and causes changes in conformation and symmetry of the “receiver”. The aim of the current work is to theoretically describe such changes primarily using a solution of the chiral protein interferon-gamma (IFNγ) as an example. We provide theoretical evidence that supramolecular systems of highly diluted (HD) aqueous solutions formed by self-assembly after mechanical activation generate a stronger molecular signal compared to non-activated solutions, due to their higher energy-saturated state. Additionally, molecular signals cause supramolecular systems with complex (including chiral) structures to undergo easier changes in conformation and symmetry compared to simpler systems, enhancing their biological activity. Using statistical physics, we obtained the parameter Ic, characterizing the magnitude of conformational and symmetry changes in supramolecular (including chiral) systems caused by molecular signals. In quantum information science, there is an analogue of the parameter Ic, which characterizes the entanglement depth of quantum systems. This study contributes to the understanding of the physico-chemical basis of distant molecular interactions and opens up new possibilities for controlling the properties of complex biological and chemical systems.