Ming-Chien Chyu

Ming-Chien Chyu


Research Focus & Metrics

Academic Career Length

21Years (2006-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 January 2018 in Nutrition Research
Verified
Journal Article
Closed access
ECEunhee Chung
Eunhee Chung
HMHuanbiao Mo
Huanbiao Mo
Shu WangShu Wang
Shu Wang
YZyujiao zu
yujiao zu
MEManal Elfakhani
Manal Elfakhani
Chwan-Li ShenChwan-Li Shen
Chwan-Li Shen

28 October 2020 in Antioxidants
Verified
Journal Article
Open access
PDF file
HLHui-Ying Luk
Hui-Ying Luk
CACasey Appell
Casey Appell
MCMing-Chien Chyu
Ming-Chien Chyu
Chung-Hwan ChenChung-Hwan Chen
Chung-Hwan Chen
Chien-Yuan WangChien-Yuan Wang
Chien-Yuan Wang
Chwan-Li ShenChwan-Li Shen
Chwan-Li Shen
Osteoarthritis and sarcopenia are two major joint and skeletal muscle diseases prevalent during aging. Osteoarthritis is a multifactorial progressive degenerative and inflammatory disorder of articular cartilage. Cartilage protection and pain management are the two most important strategies in the management of osteoarthritis. Sarcopenia, a condition of loss of muscle mass and strength, is associated with impaired neuromuscular innervation, the transition of skeletal muscle fiber type, and reduced muscle regenerative capacity. Management of sarcopenia requires addressing both skeletal muscle quantity and quality. Emerging evidence suggests that green tea catechins play an important role in maintaining healthy joints and skeletal muscle. This review covers (i) the prevalence and etiology of osteoarthritis and sarcopenia, such as excessive inflammation and oxidative stress, mitochondrial dysfunction, and reduced autophagy; (ii) the effects of green tea catechins on joint health by downregulating inflammatory signaling mediators, upregulating anabolic mediators, and modulating miRNAs expression, resulting in reduced chondrocyte death, collagen degradation, and cartilage protection; (iii) the effects of green tea catechins on skeletal muscle health via maintaining a dynamic balance between protein synthesis and degradation and boosting the synthesis of mitochondrial energy metabolism, resulting in favorable muscle homeostasis and mitigation of muscle atrophy with aging; and (iv) the current study limitations and future research directions.

9 December 2010 in BMC Complementary and Alternative Medicine
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Journal Article
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Chwan-Li ShenChwan-Li Shen
Chwan-Li Shen
MCMing-Chien Chyu
Ming-Chien Chyu
BPBarbara C Pence
Barbara C Pence
JYJames K Yeh
James K Yeh
YZYan Zhang
Yan Zhang
JWJia-Sheng Wang
Jia-Sheng Wang
Evidence suggests that both green tea polyphenols (GTP) and Tai Chi (TC) exercise may benefit bone health in osteopenic women. However, their safety in this population has never been systematically investigated. In particular, there have been hepatotoxicity concerns related to green tea extract. This study was to evaluate the safety of 24 weeks of GTP supplementation combined with TC exercise in postmenopausal osteopenic women, along with effects on quality of life in this population.

1 January 2015 in Journal of Healthcare Engineering
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Journal Article
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MCMing-Chien Chyu
Ming-Chien Chyu
TATony Austin
Tony Austin
FCFethi Calisir
Fethi Calisir
SCSamuel Chanjaplammootil
Samuel Chanjaplammootil
MDMark J. Davis
Mark J. Davis
YZYuan-Ting Zhang
Yuan-Ting Zhang
Engineering has been playing an important role in serving and advancing healthcare. The term “Healthcare Engineering” has been used by professional societies, universities, scientific authors, and the healthcare industry for decades. However, the definition of “Healthcare Engineering” remains ambiguous. The purpose of this position paper is to present a definition of Healthcare Engineering as an academic discipline, an area of research, a field of specialty, and a profession. Healthcare Engineering is defined in terms of what it is, who performs it, where it is performed, and how it is performed, including its purpose, scope, topics, synergy, education/training, contributions, and prospects.

4 September 2009 in BMC Musculoskeletal Disorders
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Journal Article
Open access
PDF file
Chwan-Li ShenChwan-Li Shen
Chwan-Li Shen
MCMing-Chien Chyu
Ming-Chien Chyu
JYJames K Yeh
James K Yeh
CFCarol K Felton
Carol K Felton
KXKe T Xu
Ke T Xu
JWJia-Sheng Wang
Jia-Sheng Wang
Osteoporosis is a major health problem in postmenopausal women. Evidence suggests the importance of oxidative stress in bone metabolism and bone loss. Tea consumption may be beneficial to osteoporosis due to its antioxidant capability. However, lack of objective data characterizing tea consumption has hindered the precise evaluation of the association between tea ingestion and bone mineral density in previous questionnaire-based epidemiological studies. On the other hand, although published studies suggest that Tai Chi (TC) exercise can benefit bone health and may reduce oxidative stress, all studies were conducted using a relatively healthy older population, instead of a high-risk one such as osteopenic postmenopausal women. Therefore, this study was designed to test an intervention including green tea polyphenol (GTP) and TC exercise for feasibility, and to quantitatively assess their individual and interactive effects on postmenopausal women with osteopenia.

5 August 2009 in International Journal of Refrigeration
Verified
Journal Article
Closed access
MCMing-Chien Chyu
Ming-Chien Chyu
JZJ. Zheng
J. Zheng
ZAZ. Ayub
Z. Ayub