Emre Gazyakan

Dr. Emre Gazyakan

orcid

Research Focus & Metrics

Academic Career Length

21Years (2006-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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19 April 2019 in Microsurgery
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Journal Article
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YZYing Zhang
Ying Zhang
EGEmre Gazyakan
Emre Gazyakan
ABAmir Khosrow Bigdeli
Amir Khosrow Bigdeli
PWPatrick Will‐Marks
Patrick Will‐Marks
UKUlrich Kneser
Ulrich Kneser
CHChristoph Hirche
Christoph Hirche

19 April 2023 in Journal of Clinical Medicine
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Journal Article
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FSFelix Strübing
Felix Strübing
FWFabian Wenz
Fabian Wenz
NENima Etminan
Nima Etminan
ABAmir Khosrow Bigdeli
Amir Khosrow Bigdeli
LSLaura Cosima Siegwart
Laura Cosima Siegwart
EGEmre Gazyakan
Emre Gazyakan
Background: Complex scalp defects are regularly reconstructed using microvascular tissue transfer. The latissimus dorsi free flap is one of the workhorse flaps used in scalp reconstruction. These cases necessitate, particularly in the elderly, a close cooperation between plastic surgeons and neurosurgeons. The purpose of this study was to evaluate the suitability of the latissimus dorsi free flap for complex scalp reconstructions and to analyze potential risk factors. Methods: A retrospective study identified 43 patients undergoing complex scalp reconstruction using a latissimus dorsi free flap at our department between 2010 and 2022. Results: The mean patient age was 61 ± 18 years. Defects were mostly caused by oncologic tumor resections (n = 23; 55%), exposure to a cranioplasty (n = 10; 23%) or infection (n = 4; 9%). The most frequent recipient vessels were the superficial temporal artery (n = 28; 65%), external carotid artery (n = 12; 28%) and the venae comitantes (n = 28; 65%), external jugular vein (n = 6; 14%). The reconstructive success rate was 97.7%. There was one total flap loss (2%). Partial flap loss occurred in five cases (12%). Follow-up was 8 ± 12 months. Major complications were seen in 13 cases, resulting in a revision rate of 26%. Multivariate logistic regression identified active tobacco use as the only risk factor for major complications (odds ratio 8.9; p = 0.04). Conclusion: Reconstruction of complex scalp defects using the latissimus dorsi free flap yielded high success rates. Among the potential risk factors, active tobacco use seems to affect the outcome of complex scalp reconstructions.

21 August 2020 in Microsurgery
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ABAmir Khosrow Bigdeli
Amir Khosrow Bigdeli
BTBenjamin Thomas
Benjamin Thomas
FFFlorian Falkner
Florian Falkner
CRChristian Andreas Radu
Christian Andreas Radu
EGEmre Gazyakan
Emre Gazyakan
UKUlrich Kneser
Ulrich Kneser

2 September 2022 in Cancers
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Journal Article
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BTBenjamin Thomas
Benjamin Thomas
ABAmir Khosrow Bigdeli
Amir Khosrow Bigdeli
SNSteffen Nolte
Steffen Nolte
EGEmre Gazyakan
Emre Gazyakan
Leila HarhausLeila Harhaus
Leila Harhaus
Ulrich KneserUlrich Kneser
Ulrich Kneser
Although the involvement of plastic surgery has been deemed important in the treatment of sarcoma patients to avoid oncological compromises and ameliorate patient outcomes, it is not ubiquitously available. The accessibility of defect reconstruction and its therapeutic impact on sarcoma care is the subject of this analysis. Cross-sectional data from 1309 sarcoma patients were collected electronically at 39 German study centers from 2017 to 2019. A total of 621 patients with surgical treatment for non-visceral soft-tissue sarcomas were included. The associated factors were analyzed exploratively using multifactorial logistic regression to identify independent predictors of successful defect reconstruction, as well Chi-squared and Cochran–Mantel–Haenszel tests to evaluate subgroups, including limb-salvage rates in extremity cases. A total of 76 patients received reconstructive surgery, including 52 local/pedicled versus 24 free flaps. Sarcomas with positive margins upon first resection (OR = 2.3, 95%CI = 1.2–4.4) that were excised at centers with lower degrees of specialization (OR = 2.2, 95%CI = 1.2–4.2) were independently associated with the need for post-oncological defect coverage. In this context, the inhouse availability of plastic surgery (OR = 3.0, 95%CI = 1.6–5.5) was the strongest independent predictor for successful flap-based reconstruction, which in turn was associated with significantly higher limb-salvage rates (OR = 1.4, 95%CI = 1.0–2.1) in cases of extremity sarcomas (n = 366, 59%). In conclusion, consistent referral to specialized interdisciplinary sarcoma centers significantly ameliorates patient outcomes by achieving higher rates of complete resections and offering unrestricted access to plastic surgery. The latter in particular proved indispensable for limb salvage through flap-based defect reconstruction after sarcoma resection. In fact, although there remains a scarcity of readily available reconstructive surgery services within the current sarcoma treatment system in Germany, plastic and reconstructive flap transfer was associated with significantly increased limb-salvage rates in our cohort.

25 October 2018 in Microsurgery
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Journal Article
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ABAmir Khosrow Bigdeli
Amir Khosrow Bigdeli
BTBenjamin Thomas
Benjamin Thomas
VSVolker J. Schmidt
Volker J. Schmidt
DKDimitra Kotsougiani
Dimitra Kotsougiani
FHFrederick J. Hernekamp
Frederick J. Hernekamp
EGEmre Gazyakan
Emre Gazyakan

16 July 2021 in Medicina
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BZBenjamin Ziegler
Benjamin Ziegler
Gabriel HundeshagenGabriel Hundeshagen
Gabriel Hundeshagen
JWJan Warszawski
Jan Warszawski
EGEmre Gazyakan
Emre Gazyakan
Ulrich KneserUlrich Kneser
Ulrich Kneser
CHChristoph Hirche
Christoph Hirche
Microsurgical free flap reconstruction in acute burn care offers the option of reconstructing even challenging defects in a single stage procedure. Due to altered rheological and hemodynamic conditions in severely burned patients, it bears the risk of a higher complication rate compared to microsurgical reconstruction in other patients. To avoid failure, appropriate indications for free flap reconstruction should be reviewed thoroughly. Several aspects concerning timing of the procedure, individual flap choice, selection and preparation of the recipient vessels, and perioperative measures must be considered. Respecting these specific conditions, a low complication rate, comparable to those seen in microsurgical reconstruction of other traumatic limb defects, can be observed. Hence, the free flap procedure in acute burn care is a relatively safe and reliable tool in the armamentarium of acute burn surgery. In reconstructive burn care, microsurgical tissue transfer is routinely used to treat scar contractures. Due to the more robust perioperative condition of patients, even lower rates of complication are seen in microsurgical reconstruction.