Laura Cosima Siegwart

Dr. Laura Cosima Siegwart

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Research Focus & Metrics

Academic Career Length

7Years (2020-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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19 April 2023 in Journal of Clinical Medicine
Verified
Journal Article
Open access
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FSFelix Strübing
Felix Strübing
FWFabian Wenz
Fabian Wenz
NENima Etminan
Nima Etminan
ABAmir Khosrow Bigdeli
Amir Khosrow Bigdeli
LSLaura Cosima Siegwart
Laura Cosima Siegwart
EGEmre Gazyakan
Emre Gazyakan
Background: Complex scalp defects are regularly reconstructed using microvascular tissue transfer. The latissimus dorsi free flap is one of the workhorse flaps used in scalp reconstruction. These cases necessitate, particularly in the elderly, a close cooperation between plastic surgeons and neurosurgeons. The purpose of this study was to evaluate the suitability of the latissimus dorsi free flap for complex scalp reconstructions and to analyze potential risk factors. Methods: A retrospective study identified 43 patients undergoing complex scalp reconstruction using a latissimus dorsi free flap at our department between 2010 and 2022. Results: The mean patient age was 61 ± 18 years. Defects were mostly caused by oncologic tumor resections (n = 23; 55%), exposure to a cranioplasty (n = 10; 23%) or infection (n = 4; 9%). The most frequent recipient vessels were the superficial temporal artery (n = 28; 65%), external carotid artery (n = 12; 28%) and the venae comitantes (n = 28; 65%), external jugular vein (n = 6; 14%). The reconstructive success rate was 97.7%. There was one total flap loss (2%). Partial flap loss occurred in five cases (12%). Follow-up was 8 ± 12 months. Major complications were seen in 13 cases, resulting in a revision rate of 26%. Multivariate logistic regression identified active tobacco use as the only risk factor for major complications (odds ratio 8.9; p = 0.04). Conclusion: Reconstruction of complex scalp defects using the latissimus dorsi free flap yielded high success rates. Among the potential risk factors, active tobacco use seems to affect the outcome of complex scalp reconstructions.

1 August 2022 in Burns
Verified
Journal Article
Closed access
CTC. Tapking
C. Tapking
LSLaura Cosima Siegwart
Laura Cosima Siegwart
YJY. Jost
Y. Jost
Gabriel HundeshagenGabriel Hundeshagen
Gabriel Hundeshagen
DKD. Kotsougiani-Fischer
D. Kotsougiani-Fischer
SFSebastian Fischer
Sebastian Fischer

31 March 2023 in Journal of Clinical Medicine
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Journal Article
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CTChristian Tapking
Christian Tapking
VRVictoria Rontoyanni
Victoria Rontoyanni
YDYannick Fabian Diehm
Yannick Fabian Diehm
FSFelix Strübing
Felix Strübing
FSFarzan Solimani
Farzan Solimani
LSLaura Cosima Siegwart
Laura Cosima Siegwart
The treatment of geriatric burn patients represents a major challenge in burn care. The objective of this study was to evaluate the efficacy of enzymatic debridement (ED) in geriatric burn patients. Adult patients who received ED for treatment of mixed pattern and full thickness burns (August 2017–October 2022) were included in this study and grouped in the younger (18–65 years) and geriatric (≥65 years) groups. Primary outcome was a necessity of surgery subsequent to ED. Both groups (patient characteristics, surgical and non-surgical treatment) were compared. Multiple logistic and linear regression models were used to identify the effect of age on the outcomes. A total of 169 patients were included (younger group: 135 patients, geriatric group: 34 patients). The burn size as indicated by %TBSA (24.2 ± 20.4% vs. 26.8 ± 17.1%, p = 0.499) was similar in both groups. The ASA (2.5 ± 1.1 vs. 3.4 ± 1.1, p < 0.001) and ABSI scores (6.1 ± 2.8 vs. 8.6 ± 2.3, p < 0.001) were significantly higher in the geriatric group. The %TBSA treated with ED (5.4 ± 5.0% vs. 4.4 ± 4.3%, p = 0.245) were similar in both groups. The necessity of additional surgical interventions (63.0 % vs. 58.8 %, p = 0.763) and the wound size debrided and grafted (2.9 ± 3.5% vs. 2.2 ± 2.1%; p = 0.301) were similar in both groups. Regression models yielded that age did not have an effect on efficacy of ED. We showed that ED is reliable and safe to use in geriatric patients. Age did not have a significant influence on the surgical outcomes of ED. In both groups, the size of the grafted area was reduced and, in many patients, surgery was avoided completely.

29 October 2021 in Journal of Clinical Medicine
Verified
Journal Article
Open access
PDF file
LSLaura Cosima Siegwart
Laura Cosima Siegwart
ABAnca Bolbos
Anca Bolbos
VHValentin Felix Haug
Valentin Felix Haug
YDYannick Fabian Diehm
Yannick Fabian Diehm
Ulrich KneserUlrich Kneser
Ulrich Kneser
DKDimitra Kotsougiani-Fischer
Dimitra Kotsougiani-Fischer
The transverse musculocutaneous gracilis (TMG) flap has become a popular choice for breast reconstruction. This study aimed to compare the donor site morbidity in unilateral and bilateral procedures. Patients receiving a TMG flap (January 2008–October 2019) were invited to a follow-up and grouped according to unilateral (UL group) or bilateral (BL group) breast reconstruction. Outcome criteria included sensation, function and aesthesis of the thighs. Patient-reported outcomes were surveyed using validated questionnaires. The number and kind of refinement procedures for aesthetic purposes on the donor thighs were evaluated. Thirty-eight patients with 59 TMG flaps were included in the study (UL group: n = 17, BL group: n = 21). Normal to slightly diminished superficial skin sensation was maintained in most of the thigh skin (98.4%). Strength and mobility were without impairment in >80% of the thighs in both groups. Thigh symmetry was achieved in both groups. Symmetrisation procedures were significantly more often performed in the UL group (p = 0.005). The total number of refinement procedures was similar in both groups. Patient-reported outcomes were similar with good appearance of the thighs and scars, excellent function and low pain levels. The TMG flap offers excellent function and sensation on the donor thigh. Thigh symmetry and good patient satisfaction may be achieved in both unilateral and bilateral breast reconstructions.

Verified
Journal Article
Open access
PDF file
LSLaura Cosima Siegwart
Laura Cosima Siegwart
CTChristian Tapking
Christian Tapking
YDYannick Fabian Diehm
Yannick Fabian Diehm
VHValentin Felix Haug
Valentin Felix Haug
ABAmir Khosrow Bigdeli
Amir Khosrow Bigdeli
DKDimitra Kotsougiani-Fischer
Dimitra Kotsougiani-Fischer
The objective of this study was to examine the impact of closed incision negative pressure therapy (CINPT) on donor site complications and patient perceptions in transverse musculocutaneous gracilis (TMG) flap breast reconstruction. Our institution conducted a retrospective cohort study, including all patients with TMG flap breast reconstruction from 1 January 2010 to 31 December 2021. Patients were grouped according to conventional wound management or CINPT. Outcomes were surgical site complications, fluid drainage, time to drain removal, and in-hospital stay length. A patient survey was created. A total of 56 patients with 83 TMG flaps were included (control group: 35 patients with 53 TMG flaps; CINPT group: 21 patients with 30 TMG flaps). Patient characteristics were similar in both groups. The flap width was significantly larger in the CINPT group (8.0 cm vs. 7.0 cm, p = 0.013). Surgical site complications were reduced in the CINPT group without statistical difference (30.0% vs. 50.9%, p = 0.064). Fluid drainage and time to drain removal were similar in both groups. The average in-hospital stay was significantly shortened in the CINPT group (10.0 days vs. 13.0 days, p = 0.030). The survey excluded pain, skin irritations, and discomfort during sleep and movement in the CINPT group and showed that the patients felt well protected. This study fails to provide compelling evidence for CINPT to enhance incision healing on the donor site in TMG flap breast reconstruction. There was a trend toward reduced surgical site complications on the donor thigh and the in-hospital stay was shortened. Prophylactic CINPT increases patient comfort and provides a feeling of additional wound protection.

22 April 2025 in The Breast
Verified
Journal Article
Open access
ABAmir Khosrow Bigdeli
Amir Khosrow Bigdeli
JTJia Wei Tee
Jia Wei Tee
FVFelix Hubertus Vollbach
Felix Hubertus Vollbach
YDYannick Fabian Diehm
Yannick Fabian Diehm
FFFlorian Falkner
Florian Falkner
LSLaura Cosima Siegwart
Laura Cosima Siegwart
The objective of this study was to evaluate microsurgical breast reconstruction as a salvage option for patients with failed implant-based breast reconstruction. We conducted a retrospective single-center study including all patients with failed unilateral implant-based breast reconstruction who elected to undergo conversion surgery to microsurgical breast reconstruction from January 2015 to December 2023. Patients were grouped according to the urgency for conversion surgery in the urgent (implant infection or extrusion) or elective (capsular contracture, patients' desire) group. Both groups were compared. 120 patients were included in the study. 101 patients (84 %) were grouped in the elective group and 19 patients (16 %) in the urgent group. Patient characteristics and intraoperative variables including the utilization of DIEP/MS-TRAM and TMG flap for microsurgical reconstruction were similar in group comparison. Patients in the urgent group had significantly more surgical interventions (3.3 vs. 2.0, p < 0.001) and suffered from significantly more major complications requiring re-operation (32 % vs. 11 %, p = 0.018) compared to the elective group. There was one flap loss in the urgent group (5 % vs. 0 %, p = 0.158). Microsurgical breast reconstruction is a reliable and safe salvage option in patients with failure of implant-based breast reconstruction. Urgent conversion to microsurgical breast reconstruction due to implant-associated complications, such as infection or extrusion, requires more surgical interventions to achieve successful breast reconstruction and has a higher rate of major complications compared to elective conversion.