Background: Prostate cancer (PCa) is a disease with a wide range of clinical manifestations. Up to the present date, the genetic understanding of patients with favorable or unfavorable prognosis is gaining interest for giving the appropriate tailored treatment. We aimed to investigate genetic changes associated with lymph node metastasis in a cohort of hormone-naïve Pca patients. Methods: We retrospectively analyzed data from 470 patients who underwent surgery for PCa between 2010 and 2020 at the Department of Urology, University of Catania. Inclusion criteria were patients with lymph node metastasis and patients with PCa with extra capsular extension (pT3) and negative lymph node metastasis. The final cohort consisted of 17 different patients (11 PCa with lymph node metastasis and 6 PCa without lymph node metastasis). Through the cBioPortal online tool, we analyzed gene alterations and their correlations with clinical factors. Results: A total of 688 intronic, synonym and nonsynonym mutations were sequenced. The gene with the most sequenced mutations was ERBB4 (83 mutations, 12% of 688 total), while the ones with the lower percentage of mutations were AKT1, FGFR2 and MLH1 (1 mutation alone, 0.14%). Conclusion: In the present study we found mostly concordance concerning the ERBB4 mutation between both primary PCa samples and matched lymph node metastasis, underlining that the identification of alterations in the primary tumor is extremely important for cancer prognosis prediction.

Background: Renal colic is a common emergency department (ED) presentation requiring rapid and accurate diagnosis. Point-of-care ultrasound (POCUS) is a fast, radiation-free alternative to CT. The Copetti sign—a rhythmic anteroposterior oscillation of the affected kidney—has been proposed as a dynamic sonographic marker of distal ureteral stones. Methods: In this prospective observational study (June–September 2025), 44 adult patients with suspected renal colic were enrolled at a single-center ED in Baggiovara, Modena, Italy. All underwent standardized POCUS to detect the Copetti sign prior to confirmatory imaging. Clinical, laboratory, and sonographic variables were collected. Associations between the Copetti sign, stone location, stone size, hydronephrosis, urinoma, and management strategy were explored. Associations with conservative management were considered exploratory. Results: The Copetti sign was identified in 70.5% of patients and was significantly associated with distal ureteral stones (74.2% vs. 25.8%, p = 0.005). Copetti-positive patients were more often managed conservatively (77.4% vs. 38.5%, p = 0.019), although this likely reflects the underlying clinical-imaging phenotype and local treatment decisions rather than a validated prognostic endpoint. Conclusions: In this prospective pilot cohort, the Copetti sign was frequently observed and was strongly associated with distal ureteral stone location. Copetti-positive patients were also more often managed conservatively, although this should be interpreted as an exploratory association reflecting clinical decision-making rather than a validated prognostic endpoint.

Telemedicine refers to the delivery of healthcare services through information and communication technologies when geographical distance separates patients and healthcare providers, enabling remote...