Carmine Cristiano Di Gioia

Dr. Carmine Cristiano Di Gioia


Research Focus & Metrics

Academic Career Length

7Years (2020-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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7 July 2024 in Healthcare
Verified
Journal Article
Open access
PDF file
DODaniele Orso
Daniele Orso
DPDaniele Peric
Daniele Peric
CGCarmine Cristiano Di Gioia
Carmine Cristiano Di Gioia
ICIrene Comisso
Irene Comisso
TBTiziana Bove
Tiziana Bove
NFNicola Federici
Nicola Federici
Renal and genitourinary ultrasound are fundamental resources employed by emergency and critical care healthcare providers to make prompt diagnoses and perform ultrasound-guided procedures. At the bedside, ultrasound can aid in the diagnosis of relevant pathologies, such as post-renal obstruction or kidney stones, and life-threatening conditions such as aortic dissection or hemoperitoneum. A narrative overview was performed, providing an updated review of renal and genitourinary ultrasound for emergency and critical care healthcare providers, emphasizing its advantages and the latest advances in the field. A thorough summary that can be utilized as a guide for emergency and critical care healthcare providers is presented. The daily hemodynamic management of critically ill patients involves the implementation of new protocols, such as VexUS or the evaluation of the renal resistance index. The role of ultrasound in managing acute nephropathy and genitourinary issues is increasingly crucial given its bedside availability, thus this imaging modality not only facilitates the initiation of therapeutic interventions but also provides swift prognostic insights that are vital to provide tailored patient care. As further advances in ultrasound will arise, it is important for healthcare providers to foster the use of these technologies capable of improving patient outcomes.

4 December 2024 in Medicina
Verified
Journal Article
Open access
PDF file
CGCarmine Cristiano Di Gioia
Carmine Cristiano Di Gioia
AAAlice Alame
Alice Alame
DODaniele Orso
Daniele Orso
Background and Objectives: Small bowel obstruction (SBO) requires prompt diagnosis and management. Due to its advantages, POCUS can be beneficial when assessing SBO. However, it is still doubtful whether POCUS performed by an emergency doctor can prolong the time of patients with SBO in the emergency department (ED). The primary outcome was time to diagnosis when using POCUS compared to not using it. Secondary outcomes included the processing time in the ED, ED length of stay (LOS), rates of abdominal radiography, hospital LOS, and mortality. Materials and Methods: We conducted a retrospective, observational study in our ED from 1 November 2021 to 31 December 2023, including patients aged 18 and older diagnosed with SBO. Both groups received confirmation of their diagnosis through contrast-enhanced computed tomography. The two groups of patients (POCUS group vs. non-POCUS group) were compared regarding the time needed to reach the final diagnosis (i.e., time to diagnosis), the ED LOS, the hospital LOS, and in-hospital mortality. Results: A total of 106 patients were included. The median time to diagnosis was 121 min for the POCUS group vs. 217 min for the non-POCUS group (p < 0.001). Median ED processing time was 276 min in the POCUS group compared to 376 min in the non-POCUS group (p = 0.006). ED LOS was also shorter in the POCUS group (333 vs. 436 min, p = 0.010). Abdominal X-ray rates were lower in the POCUS group (49% vs. 78%, p = 0.004). Hospital LOS was similar between the two groups (p = 1.000). Five non-POCUS patients died during hospitalization; none died in the POCUS group, but the difference was not statistically significant (p = 0.063). Conclusions: POCUS significantly reduced time to diagnosis and ED LOS. Further exploration is needed to assess long-term outcomes and the cost-effectiveness of integrating POCUS into ED practice.

22 December 2021 in Emergency Medicine Journal
Verified
Journal Article
Closed access
PDF file
CGCarmine Cristiano Di Gioia
Carmine Cristiano Di Gioia
NANicola Artusi
Nicola Artusi
GXGiovanni Xotta
Giovanni Xotta
MBMarco Bonsano
Marco Bonsano
USUgo Giulio Sisto
Ugo Giulio Sisto
RCRoberto Copetti
Roberto Copetti
Purpose Early diagnosis of COVID-19 has a crucial role in confining the spread among the population. Lung ultrasound (LUS) was included in the diagnostic pathway for its high sensitivity, low costs, non-invasiveness and safety. We aimed to test the sensitivity of LUS to rule out COVID-19 pneumonia (COVIDp) in a population of patients with suggestive symptoms. Methods Multicentre prospective observational study in three EDs in Northeastern Italy during the first COVID-19 outbreak. A convenience sample of 235 patients admitted to the ED for symptoms suggestive COVIDp (fever, cough or shortness of breath) from 17 March 2020 to 26 April 2020 was enrolled. All patients underwent a sequential assessment involving: clinical examination, LUS, CXR and arterial blood gas. The index test under investigation was a standardised protocol of LUS compared with a pragmatic composite reference standard constituted by: clinical gestalt, real-time PCR test, radiological and blood gas results. Of the 235 enrolled patients, 90 were diagnosed with COVIDp according to the reference standard. Results Among the patients with suspected COVIDp, the prevalence of SARS-CoV-2 was 38.3%. The sensitivity of LUS for diagnosing COVIDp was 85.6% (95% CI 76.6% to 92.1%); the specificity was 91.7% (95% CI 86.0% to 95.7%). The positive predictive value and the negative predictive value were 86.5% (95%CI 78.8% to 91.7%) and 91.1% (95% CI 86.1% to 94.4%) respectively. The diagnostic accuracy of LUS for COVIDp was 89.4% (95% CI 84.7% to 93.0%). The positive likelihood ratio was 10.3 (95% CI 6.0 to 17.9), and the negative likelihood ratio was 0.16 (95% CI 0.1 to 0.3). Conclusion In a population with high SARS-CoV-2 prevalence, LUS has a high sensitivity (and negative predictive value) enough to rule out COVIDp in patients with suggestive symptoms. The role of LUS in diagnosing patients with COVIDp is perhaps even more promising. Nevertheless, further research with adequately powered studies is needed. Trial registration number NCT04370275.

1 October 2020 in European Journal of Internal Medicine
Verified
Journal Article
Open access
RCRoberto Copetti
Roberto Copetti
GAGiulia Amore
Giulia Amore
CGCarmine Cristiano Di Gioia
Carmine Cristiano Di Gioia
DODaniele Orso
Daniele Orso
The SARS-CoV-2 epidemic, which has spread to many countries around the world, has hit Europe particularly hard. From our point of view, in a rural emergency department (with an annual patient census of around 25,000) in northeastern Italy, it is necessary to preserve the hospital and prevent it from becoming an outbreak of infection. In our experience, we reevaluated the negative predictive value of lung ultrasound to rule out lung involvement. Since severe acute respiratory failure appears to be the leading cause of death for COVID-19 patients, it is essential to focus on this clinical feature. We currently believe that a patient suspected of COVID-19, if he has a normal ultrasound examination (a so-called "A-profile"), can be discharged home to continue isolation and be treated without being hospitalized.

11 June 2026 in Healthcare
Verified
Journal Article
Open access
PDF file
CGCarmine Cristiano Di Gioia
Carmine Cristiano Di Gioia
DODaniele Orso
Daniele Orso
AAAlice Alame
Alice Alame
JVJessica Vella
Jessica Vella
MDMichela D’Apolito
Michela D’Apolito
MBMarcello Boccardi
Marcello Boccardi
Background: Renal colic is a common emergency department (ED) presentation requiring rapid and accurate diagnosis. Point-of-care ultrasound (POCUS) is a fast, radiation-free alternative to CT. The Copetti sign—a rhythmic anteroposterior oscillation of the affected kidney—has been proposed as a dynamic sonographic marker of distal ureteral stones. Methods: In this prospective observational study (June–September 2025), 44 adult patients with suspected renal colic were enrolled at a single-center ED in Baggiovara, Modena, Italy. All underwent standardized POCUS to detect the Copetti sign prior to confirmatory imaging. Clinical, laboratory, and sonographic variables were collected. Associations between the Copetti sign, stone location, stone size, hydronephrosis, urinoma, and management strategy were explored. Associations with conservative management were considered exploratory. Results: The Copetti sign was identified in 70.5% of patients and was significantly associated with distal ureteral stones (74.2% vs. 25.8%, p = 0.005). Copetti-positive patients were more often managed conservatively (77.4% vs. 38.5%, p = 0.019), although this likely reflects the underlying clinical-imaging phenotype and local treatment decisions rather than a validated prognostic endpoint. Conclusions: In this prospective pilot cohort, the Copetti sign was frequently observed and was strongly associated with distal ureteral stone location. Copetti-positive patients were also more often managed conservatively, although this should be interpreted as an exploratory association reflecting clinical decision-making rather than a validated prognostic endpoint.