Chronic wounds are defined as wounds that do not heal in an orderly and timely manner through the various stages of the healing process. Copper nanoparticles are essential in dressings for wound healing because they promote angiogenesis and skin regeneration, which hasten the healing process. This systematic investigation sought to explain how copper nanoparticles affect chronic wound healing in vivo and in vitro. We realized a systematic review of original articles studying the effectiveness of copper nanoparticles in the healing process of chronic wounds. The protocol was registered in the PROSPERO database. Several databases were searched between 2012 and January 2022 for English-language papers using MeSH terms and text related to chronic wounds, copper nanoparticles, and wound healing. Quality was evaluated using National Institute for Health and Care Excellence methodology and PRISMA guidelines. We looked at a total of 12 primary studies. Quantitative data were gathered and presented in all studies. Our results suggest that copper nanoparticles could have an excellent healing property, facilitating the liberation of growth factors that help the anti-inflammatory process of the wound and significantly improving antibacterial and antioxidant activities. In addition, copper presents a higher biocompatibility than other metallic ions, promoting regeneration and increasing skin quality.

CuCN was investigated by chemical analysis, IR spectroscopy and powder X-ray diffraction. A high-temperature phase of CuCN was identified and structurally characterized by Rietveld refinement. HT-CuCN is isotypic to AgCN (R3m (No. 166), Z = 3, a = 597.109(8), c = 484.33(5) pm, Cu (3a), C/N (6c), z = 0.3915(10) at 77 K) with head-tail disorder of the cyanide anions.

Based on the qualities of Ulmo honey (Eucryphia cordifolia), a medical-grade honey (Ulmoplus^®) has been developed. Relevant to this, the use of copper represents an emerging therapy for the treatment of wounds. Therefore, the aim of this study was to see how this medical-grade honey with copper nanoparticles (CuNPs) helped to heal infected or non-infected wounds. Twenty-four guinea pigs (Cavia porcellus) were divided into four groups for phase 1 (without and with infection, U + F₁ and U + F₂), and two groups for phase 2 (selected formulation, without and with infection, U + F₂NI and U + F₂I). Bacteriological and histopathological studies, collagen fibers content evaluation, and stereological analysis were performed. The selected formulation displayed the same antibacterial potency as Ulmoplus^®, indicating that this medical-grade honey by itself can be used as an antibacterial agent. However, the evaluation of collagen content demonstrated a significant increase in fibroblast and type III collagen fibers for infected and uninfected groups, which correlated with the histopathological study. Therefore, it is correct to affirm that adding CuNPs to Ulmoplus^® improved the maturation of collagen fibers. Finally, polymorphonuclear cells presented similar values between experimental groups, which would indicate that the formulation under study was able to regulate the inflammatory process despite their infectious condition.

Experimental healing studies in humans are complex and difficult to replicate in vitro. Hence, animal models are needed to study the different stages involved. The guinea pig (Cavia porcellus) is a model close to human physiology, including the lack of vitamin C synthesis, a precursor of collagen fibers for healing. The thermal injury in this animal makes it possible to study all the stages of healing, taking few days to show tissue repair in the processes with and without localized infection. The aim of this work was to systematize an experimental guinea pig (Cavia porcellus) animal model protocol for studies on healing with and without localized infection.

La prevención de lesiones de piel, es un componente de la gestión del cuidado de enfermería. Las lesiones asociadas a adhesivos médicos (MARSI) son escasamente reportadas. Esta revisión narrativa, tuvo como objetivo sintetizar la evidencia respecto a la prevención de MARSI en la última década. Las bases de datos consultadas fueron: PubMed, Scopus, LILACS, con los términos MeSH y DeCS: Control and prevention, Asses risks, Medical Device Injuries, education y MARSI, todos vinculados a operadores boléanos AND y OR, también se consideró búsqueda dirigida con términos libres y apoyo del buscador Google Scholar para el rastreo preliminar. Los resultados concuerdan que las MARSI son desconocidas, sin evidencia de estudios primarios con aplicación de protocolos estandarizados, siendo un tema emergente en gestión del cuidado. Los hallazgos se sintetizaron por ejes temáticos claves para estandarizar la prevención, ellos fueron: valoración integral de la persona, aplicación y eliminación de los dispositivos adhesivos, capacitación al equipo de salud y educación al usuario de adhesivos médicos. Se concluye que las MARSI, son prevenibles en la medida que se reconozcan y establezcan las medidas integrales, locales y educativas que certifiquen la seguridad de las personas en riesgo.