Hongliang Lu

Prof. Hongliang Lu

Air Force Medical University, Xi'an, China
orcid

Research Focus & Metrics

Academic Career Length

9Years (2018-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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11 December 2023 in Human Brain Mapping
Verified
Journal Article
Open access
HLHongliang Lu
Hongliang Lu
YZYajuan Zhang
Yajuan Zhang
HQHuake Qiu
Huake Qiu
ZZZhilong Zhang
Zhilong Zhang
XTXuanyi Tan
Xuanyi Tan
XZXia Zhu
Xia Zhu
Background: Executive function enhancement is considered necessary for improving the quality of life of patients with neurological or psychiatric disorders, such as attention‐deficit/hyperactivity disorder, obsessive‐compulsive disorder and Alzheimer's disease. Transcranial electrical stimulation (tES) has been shown to have some beneficial effects on executive functioning, but the quantification of these improvements remains controversial. We aimed to explore the potential beneficial effects on executive functioning induced by the use of transcranial alternating current stimulation (tACS)/transcranial direct current stimulation (tDCS) on the right inferior frontal gyrus (IFG) and the accompanying brain function variations in the resting state.Methods: We recruited 229 healthy adults to participate in Experiments 1 (105 participants) and 2 (124 participants). The participants in each experiment were randomly divided into tACS, tDCS, and sham groups. The participants completed cognitive tasks to assess behavior related to three core components of executive functions. Functional near‐infrared spectroscopy (fNIRS) was used to monitor the hemodynamic changes in crucial cortical regions in the resting state.Results: Inhibition and cognitive flexibility (excluding working memory) were significantly increased after tACS/tDCS, but there were no significant behavioral differences between the tACS and tDCS groups. fNIRS revealed that tDCS induced decreases in the functional connectivity (increased neural efficiency) of the relevant cortices.Conclusions: Enhancement of executive function was observed after tES, and the beneficial effects of tACS/tDCS may need to be precisely evaluated via brain imaging indicators at rest. tDCS revealed better neural benefits than tACS during the stimulation phase. These findings might provide new insights for selecting intervention methods in future studies and for evaluating the clinical efficacy of tES.

30 August 2022 in Brain Sciences
Verified
Journal Article
Open access
PDF file
XWXinlu Wang
Xinlu Wang
HLHongliang Lu
Hongliang Lu
YHYang He
Yang He
KSKewei Sun
Kewei Sun
TFTingwei Feng
Tingwei Feng
XZXia Zhu
Xia Zhu
Introduction: It is clear that mental fatigue can have many negative impacts on individuals, such as impairing cognitive function or affecting performance. The aim of this study was to investigate the role of sound interventions in combating mental fatigue. Method: The subjects were assessed on various scales, a psychomotor vigilance task (PVT) task, and a 3 min resting-state electroencephalogram (EEG), followed by a 20 min mental fatigue–inducing task (Time Load Dual Back, TloadDback), during which subjects in different condition groups listened to either 15 Hz binaural beats, 40 Hz binaural beats, relaxing music, or a 240 Hz pure tone. After the mental fatigue–inducing task, subjects were again assessed on various scales, a PVT task, and a 3 min resting-state EEG. Results: After the fatigue-inducing task, there was no significant difference between the four groups on the scales or the PVT task performance. In TloadDback, the accuracy rate of the 40 Hz binaural beats group and the relaxing music group decreased in the middle stage of the task, while the 15 Hz binaural beats group and the 240 Hz pure tone group remained unchanged in all stages of the task. The EEG results showed that after fatigue inducement, the average path length of the 15 Hz binaural beats group decreased, and local efficiency showed an increasing tendency, indicating enhanced brain network connectivity. Meanwhile, the 240 Hz pure tone group showed enhanced functional connectivity, suggesting a state of mental fatigue in the group. Conclusions: The results of this study show that listening to 15 Hz binaural beats is a proven intervention for mental fatigue that can contribute to maintaining working memory function, enhancing brain topological structure, and alleviating the decline in brain function that occurs in a mentally fatigued state. As such, these results are of great scientific and practical value.

26 March 2024 in Current Psychology
Verified
Journal Article
Closed access
PDF file
ZGZhihua Guo
Zhihua Guo
YZYajuan Zhang
Yajuan Zhang
PPPeiyun Pi
Peiyun Pi
XZXia Zhu
Xia Zhu
YCYi Cui
Yi Cui
HLHongliang Lu
Hongliang Lu

9 May 2024 in Heliyon
Verified
Journal Article
Open access
HQHuake Qiu
Huake Qiu
HLHongliang Lu
Hongliang Lu
XWXianyang Wang
Xianyang Wang
ZGZhihua Guo
Zhihua Guo
CXChen Xing
Chen Xing
YZYan Zhang
Yan Zhang
The theories of relational regulation and compensatory Internet use suggest that intolerance of uncertainty influences smartphone addiction (SPA), which in turn is influenced by other aspects. This study used previous results to examine how intolerance of uncertainty affects SPA in PhD and master's degree programs. A convenience sample comprising 1727 master's and PhD students (99.9 %; 50.7 % female; Mage = 27.71; SD = 3.80; range = 21-43) was recruited. Using established questionnaires, we measured SPA, anxiety, positive coping style, perceived social support, and intolerance of uncertainty. The results demonstrated that intolerance of uncertainty positively affects SPA in terms of predictive power. Furthermore, anxiety and positive coping style mediate that link in a cascade fashion. A greater SPA indicates that the individual is less likely to use a positive coping style, has a higher anxiety level, and has a lower tolerance for uncertainty. While thinking about how intolerance of uncertainty affects anxiety and positive coping style, perceived social support mediates the relationship. Intolerance of uncertainty has less impact on anxiety and positive coping style when perceived social support is high. These results indicate the possibility of examining SPA prevention and intervention from several angles. Therefore, emotional regulation, which modifies anxiety and the tendency to use a positive coping style, may reduce the impact of intolerance of uncertainty on SPA. Another successful strategy for reducing smartphone addiction is to provide social support from loved ones and the community at large.

1 November 2018 in Advances in Psychological Science
Verified
Journal Article
Closed access
彦王彦志 王
彦志 王
TYTang Yao
Tang Yao
HLHongliang Lu
Hongliang Lu

27 September 2025 in Human Brain Mapping
Verified
Journal Article
Open access
HLHongliang Lu
Hongliang Lu
YMYe Miao
Ye Miao
YZYajuan Zhang
Yajuan Zhang
ZGZhihua Guo
Zhihua Guo
XWXianyang Wang
Xianyang Wang
JMJin Ma
Jin Ma
Attention is crucial for military personnel to recover from mental dysfunction and maintain superior cognitive abilities. Transcranial electrical stimulation (tES) is a promising training method for enhancing attention; however, the optimal parameters for tES interventions remain unclear. This study aims to identify the most responsive cortical area and the most effective tES type for attention enhancement. In Experiment 1, 62 healthy male soldiers were examined to determine the most effective stimulation target for attention improvement after 4 (cathodal electrodes) × 1 (anodal electrodes) high‐definition transcranial direct current stimulation (tDCS) on the right inferior frontal gyrus (IFG) or the left dorsolateral prefrontal cortex (DLPFC). Experiment 2, involving 75 participants, focused on modulating the previously identified appropriate cortex using both high‐definition transcranial alternating current stimulation (tACS) and tDCS to ascertain the most effective tES method based on behavioral and neural activity changes. Both experiments were double‐blind and sham‐controlled. Executive control of attention networks was significantly improved after tDCS modulation of both the right IFG and the left DLPFC. Notably, only the modulation of the right IFG effectively decreased the Stroop effect. While both tACS and tDCS on the right IFG induced lower neural activity related to the Stroop effect, only tDCS significantly reduced the behavioral performance of the Stroop effect. Consequently, the right IFG emerges as a key targeted cortex for tES modulation in enhancing attention, with tDCS proving more effective than tACS in regulating the right IFG to improve executive control. These findings lay the groundwork for applying tES interventions in the training of attention abilities among military personnel.