1,3,4-Thiadiazole molecules showed an inhibitory effect for the Staphylococcus epidermidis protein.

Most industries struggle with corrosion. Corrosion inhibitors are needed in these sectors. Eco-friendly corrosion inhibitors should be effective even at low concentrations. In this work, the compound 2- Fluorophenyl-2, 5- dithiohydrazodicarbonamide (2F-TSC) was utilized as a corrosion inhibitor for copper in a 3.5% NaCl solution. The inhibitor efficiency was calculated by using a series of electrochemical methods like, open circuit potential (OCP), potentiodynamic polarization (PDP), and electrochemical impedance spectroscopy (EIS). All tests have been done in a stagnant condition. The results show that the compound 2F-TSC looked to be of mixed type. Furthermore, the maximum inhibitor efficiency was reached at 99.2% at 10-2 M 2F-TSC and 5 h. The adsorption of 2F-TSC on the copper surface in 3.5% NaCl obeyed the Langmuir isotherm with a negative value of the standard Gibbs free energy of adsorption of -35.4 kJ/mol (chemisorption and physisorption). SEM, EDX, and AFM confirmed the presence of 2F-TSC on the surface of copper. The adsorption of the inhibitor molecules on the Cu (111) surface was further verified by a Monte Carlo simulation study. The results approved that the 2F-TSC can be utilized as a corrosion inhibitor for copper in an aggressive solution (3.5% NaCl).

In this study we investigated the structure-activity relationships by using the Electron- Topological Method (ETM) for a class of AChE inhibitors related to tacrine (9-amino-1,2,3,4-tetrahydroacridine) and 11 H -Indeno-[1,2-b]-quinolin-10-ylamine that tetracyclic tacrine analogues, a drug currently in use for the treatment of the AD. Molecular fragments being specific for active and inactive compounds were revealed by using ETM. The result of testing showed the high ability of ETM in predicting the activity and inactivity in investigated series.