Heat transfer is a vital fact of daily life, engineering, and industrial mechanisms such as cryogenic systems, spaceborne thermal radiometers, electronic cooling, aircraft engine cooling, aircraft environmental control systems, etc. The addition of nanoparticles helps to stabilize the flowing of a nanofluid and keeps the symmetry of the flowing structure. Purpose: In this attempt, the effect of endothermic/exothermic chemical reactions accompanied by activation energy on a ternary hybrid nanofluid with the geometry of a wedge is taken into consideration. The mathematical form of PDEs is obtained by Navier–Stokes equations, the second law of thermodynamics, and Fick’s second law of diffusion. The geometric model is therefore described using a symmetry technique. Formulation: The MATLAB built-in Lobatto III A structure is utilized to find the computational solution of the dimensionless ODEs. All computational outcomes are presented by graphs and statistical graphs in order to check the performance of various dimensionless quantities against drag force factor and Nusselt quantity. Finding: the addition of tri-hybridizing nanomolecules in the standard liquid improves the thermic performance of the liquid much better in comparison to simple hybrid nanofluids. Wedge angle parameter $\alpha$ brings about a decrement in fluid velocity and augmentation in thermal conductivity $ϵ$, thermal radiation $Rd$, thermophoresis parameter $Nt$ and endothermic/exothermic reaction $\Omega$, and fitted rate constant $n$ accelerates the heat transmission rate. Novelty: The effect of tri-hybridizing nanomolecules along with endothermic/exothermic reactions on the fluid past a wedge have not been investigated before in the available literature.