In total knee arthroplasty, the optimal length and material of tibial stem remain controversial. This study aimed to evaluate influences of lengths and materials of cementless stems on tibial remodeling behaviors. Three groups of lengths were investigated (i.e., 110, 60, and 30 mm), and four materials (i.e., titanium, flexible 'iso-elastic' material, and two functionally graded materials [FGMs]) were selected for each group. FGM is a kind of material whose composition gradually varies in space. In this study, the compositions of two FGMs were Ti and hydroxyapatite (FGM I), and Ti and bioglass (FGM II), respectively. Tibial models were incorporated with finite element analysis to simulate bone remodeling. Distributions of bone mineral density, von Mises stress, and interface shear stress were obtained. For the length, the long stem produced more serious stress shielding and stress concentration than the short stem, but it could provide better mechanical stability. For the material, FGM I could reduce stress shielding and stress concentration and reduce the risk of loosening. Compared with the length, the material had a pronounced effect on remodeling. This study provided theoretical basis for optimal design of stem to improve service life of tibial components and to reduce pain of patients.

The negative effect of long-term working load on lumbar is widely known. However, insertion of different resting modes on long-term working load, and its effects on the lumbar spine is rarely studied. The purpose of this study was to investigate the biomechanical responses of lumbar spine with different levels of degenerated intervertebral discs under different working-resting modes. Four poroelastic finite element models of lumbar spinal segments L2-L3 with different grades of disc degeneration were developed. Four different loading conditions represented four different resting frequencies, namely, no rest, one-time long rest, three-time moderate rests, and five-time short rests, on the condition that the total resting time was the same except in the no rest mode. Loading amplitudes of diurnal activities included 100 N, 300 N, and 500 N. With increasing resting frequency, the axial effective stress and fluid loss decreased, whereas the pore pressure and radial displacement increased. Under different resting frequencies, the changing rate of each biomechanical parameter was different. Under a situation of fixed total resting time, high resting frequency was advisable. If sufficient resting frequency was unavailable for healthy people as well as patients with mildly and moderately degenerated intervertebral discs, they could similarly benefit from relatively less resting frequencies. However, one-time rest will not be useful in cases where intervertebral discs were seriously degenerated. Reasonable working-resting modes for different degrees of disc degeneration, which could assist patients achieve a better restoration, were provided in this study.

Long-term exposure to low-frequency vibration generated by vehicle driving impairs human lumbar spine health. However, few studies have investigated how low-frequency vibration affects human lumbar mechanical properties. This study established a poroelastic finite element model of human lumbar spinal segments L2–L3 to perform time-dependent vibrational simulation analysis and investigated the effects of different vibrational frequencies generated by normal vehicle driving on the lumbar mechanical properties in one hour. Analysis results showed that vibrational load caused more injury to lumbar health than static load, and vibration at the resonant frequency generated the most serious injury. The axial effective stress and the radial displacement in the intervertebral disc, as well as the fluid loss in the nucleus pulposus, increased, whereas the pore pressure in the nucleus pulposus decreased with increased vibrational frequency under the same vibrational time, which may aggravate the injury degree of human lumbar spine. Therefore, long-term driving on a well-paved road also induces negative effects on human lumbar spine health. When driving on a nonpaved road or operating engineering machinery under poor navigating condition, the auto seat transmits relatively high vibrational frequency, which is highly detrimental to the lumbar spine health of a driver.

Bone mechanical properties vary with age; meanwhile, a close relationship exists among bone mechanical properties at different levels. Therefore, conducting multilevel analyses for bone structures with different ages are necessary to elucidate the effects of aging on bone mechanical properties at different levels. In this study, an approach that combined microfinite element (micro-FE) analysis and macrocompressive test was established to simulate the failure of male rat femoral cortical bone. Micro-FE analyses were primarily performed for rat cortical bones with different ages to simulate their failure processes under compressive load. Tissue-level failure strains in tension and compression of these cortical bones were then back-calculated by fitting the experimental stress–strain curves. Thus, tissue-level failure strains of rat femoral cortical bones with different ages were quantified. The tissue-level failure strain exhibited a biphasic behavior with age: in the period of skeletal maturity (1–7 months of age), the failure strain gradually increased; when the rat exceeded 7 months of age, the failure strain sharply decreased. In the period of skeletal maturity, both the macro- and tissue-levels mechanical properties showed a large promotion. In the period of skeletal aging (9–15 months of age), the tissue-level mechanical properties sharply deteriorated; however, the macromechanical properties only slightly deteriorated. The age-related changes in tissue-level failure strain were revealed through the analysis of male rat femoral cortical bones with different ages, which provided a theoretical basis to understand the relationship between rat cortical bone mechanical properties at macro- and tissue-levels and decrease of bone strength with age.

Introduction: The principal strain or equivalent strain is mainly used in current numerical studies to determine the mechanical state of the element in the cortical bone finite element model and then perform fracture simulation. However, it is unclear which strain is more suitable for judging the element mechanical state under different loading conditions due to the lack of a general strain judging criterion for simulating the cortical bone fracture.Methods: This study aims to explore a suitable strain judging criterion to perform compressive fracture simulation on the rat femoral cortical bone based on continuum damage mechanics. The mechanical state of the element in the cortical bone finite element model was primarily assessed using the principal strain and equivalent strain separately to carry out fracture simulation. The prediction accuracy was then evaluated by comparing the simulated findings with different strain judging criteria to the corresponding experimental data.Results: The results showed that the fracture parameters predicted using the principal strain were closer to the experimental values than those predicted using the equivalent strain.Discussion: Therefore, the fracture simulation under compression was more accurate when the principal strain was applied to control the damage and failure state in the element. This finding has the potential to improve prediction accuracy in the cortical bone fracture simulation.