A hybrid cooling system which combines natural ventilation with a radiant cooling system for a hot and humid climate was studied. Indirect evaporative cooling was used to produce chilled water at temperatures slightly higher than the dew point. With this hybrid system, the condensation issue on the panel surface of a chilled ceiling was overcome. A computational fluid dynamics (CFD) model was employed to determine the cooling load and the parameters required for thermal comfort analysis for this hybrid system in an office-sized, well-insulated test room. Upon closer investigation, it was found that the thermal comfort by the hybrid system was acceptable only in limited outdoor conditions. Therefore, the hybrid system with a secondary fresh air supply system was suggested. Furthermore, the energy consumptions of conventional all-air, radiant cooling, and hybrid systems including the secondary air supply system were compared under similar thermal comfort conditions. The predicted results indicated that the hybrid system saves up to 77% and 61% of primary energy when compared with all-air and radiant cooling systems, respectively, while maintaining similar thermal comfort.