Recently, deep convolutional neural networks (CNNs) have been successfully applied to the single-image super-resolution (SISR) task with great improvement in terms of both peak signal-to-noise ratio (PSNR) and structural similarity (SSIM). However, most of the existing CNN-based SR models require high computing power, which considerably limits their real-world applications. In addition, most CNN-based methods rarely explore the intermediate features that are helpful for final image recovery. To address these issues, in this article, we propose a dense lightweight network, called MADNet, for stronger multiscale feature expression and feature correlation learning. Specifically, a residual multiscale module with an attention mechanism (RMAM) is developed to enhance the informative multiscale feature representation ability. Furthermore, we present a dual residual-path block (DRPB) that utilizes the hierarchical features from original low-resolution images. To take advantage of the multilevel features, dense connections are employed among blocks. The comparative results demonstrate the superior performance of our MADNet model while employing considerably fewer multiadds and parameters.

Deep convolutional neural networks (CNNs) have contributed to the significant progress of the single-image super-resolution (SISR) field. However, the majority of existing CNN-based models maintain high performance with massive parameters and exceedingly deeper structures. Moreover, several algorithms essentially have underused the low-level features, thus causing relatively low performance. In this article, we address these problems by exploring two strategies based on novel local wider residual blocks (LWRBs) to effectively extract the image features for SISR. We propose a cascading residual network (CRN) that contains several locally sharing groups (LSGs), in which the cascading mechanism not only promotes the propagation of features and the gradient but also eases the model training. Besides, we present another enhanced residual network (ERN) for image resolution enhancement. ERN employs a dual global pathway structure that incorporates nonlocal operations to catch long-distance spatial features from the the original low-resolution (LR) input. To obtain the feature representation of the input at different scales, we further introduce a multiscale block (MSB) to directly detect low-level features from the LR image. The experimental results on four benchmark datasets have demonstrated that our models outperform most of the advanced methods while still retaining a reasonable number of parameters.

Alzheimer's disease (AD) is one of the most common progressive neurodegenerative diseases. Structural magnetic resonance imaging (MRI) would provide abundant information on the anatomical structure of human organs. Fluorodeoxy‐glucose positron emission tomography (PET) obtains the metabolic activity of the brain. Previous studies have demonstrated that multi‐modality images could contribute to improve diagnosis of AD. However, these methods need to extract the handcrafted features that demand domain specific knowledge and image processing stage is time consuming. In order to tackle these problems, in this study, the authors propose a novel framework that ensembles three state‐of‐the‐art deep convolutional neural networks (DCNNs) with multi‐modality images for AD classification. In detail, they extract some slices from each subject of each modality, and every DCNN generates a probabilistic score for the input slices. Furthermore, a ‘dropout’ mechanism is introduced to discard low discrimination slices of the category probabilities. Then average reserved slices of each subject are acquired as a new feature. Finally, they train the Adaboost ensemble classifier based on single decision tree classifier with the MRI and PET probabilistic scores of each DCNN. Evaluations on Alzheimer's Disease Neuroimaging Initiative database show that the proposed algorithm has better performance compared to existing method, the algorithm proposed in this study significantly improved the classification accuracy.

The increased amount of tertiary lymphoid structures (TLSs) is associated with a favorable prognosis in patients with lung adenocarcinoma (LUAD). However, evaluating TLSs manually is an experience-dependent and time-consuming process, which limits its clinical application. In this multi-center study, we developed an automated computational workflow for quantifying the TLS density in the tumor region of routine hematoxylin and eosin (H&E)-stained whole-slide images (WSIs). The association between the computerized TLS density and disease-free survival (DFS) was further explored in 802 patients with resectable LUAD of three cohorts. Additionally, a Cox proportional hazard regression model, incorporating clinicopathological variables and the TLS density, was established to assess its prognostic ability. The computerized TLS density was an independent prognostic biomarker in patients with resectable LUAD. The integration of the TLS density with clinicopathological variables could support individualized clinical decision-making by improving prognostic stratification.