This study compared the acute effects of a session of different high-intensity interval exercise (HIIE) protocols and a session of moderate-intensity continuous exercise (MICE) on blood glucose, blood pressure (BP), and heart rate (HR) in people with Type 2 Diabetes Mellitus (DM2). The trial included 44 participants (age: 55.91 ± 1.25 years; BMI: 28.95 ± 0.67 kg/m²; Hb1Ac: 9.1 ± 2.3%; 76 mmol/mol) randomized into three exercise protocols based on the velocity at which maximum oxygen consumption was obtained (vVO2 max): long HIIE (2 min at 100% vV̇o2peak + 2 min of passive rest); short HIIE (30 s at 100% vV̇o2peak + 30 s of passive rest); or MICE (14 min at 70% vV̇o2peak) on a treadmill. Capillary blood glucose, BP, and HR measurements were taken at rest, during peak exercise, immediately after the end of exercise, and 10 min after exercise. Long and short HIIE protocols reduced capillary blood glucose by 32.14 mg/dL and 31.40 mg/dL, respectively, and reduced systolic BP by 12.43 mmHg and 8.73 mmHg, respectively. No significant changes were observed for MICE. HIIE was found to promote more acute effects than MICE on glycemia and BP in people with DM2.

Background: The effects of long-distance walking on the cardiovascular system have been little studied. Objectives: The general objective of this study was to verify these effects on the behavior of diastolic function and the cardiac biomarkers CK-MB (mass), troponin T, and NT-proBNP, in amateur athletes. Method: This longitudinal study, conducted in 2015, evaluated participants during the following 5 stages: E0 (baseline) before starting the trajectory and the others, E1, E2, E3, and E4, at the end of each day, [...] Abstract Background: The effects of long-distance walking on the cardiovascular system have been little studied. Objectives: The general objective of this study was to verify these effects on the behavior of diastolic function and the cardiac biomarkers CK-MB (mass), troponin T, and NT-proBNP, in amateur athletes. Method: This longitudinal study, conducted in 2015, evaluated participants during the following 5 stages: E0 (baseline) before starting the trajectory and the others, E1, E2, E3, and E4, at the end of each day,

Objetivo: Avaliar as respostas agudas do exercício com cicloergômetro no pós-operatório de idosos e idosos longevos submetidos ao implante transcateter de válvula aórtica (TAVI), incluindo a segurança e viabilidade do exercício físico. Métodos: Ensaio clínico não randomizado com 39 pacientes. Coletadas variáveis de pressão arterial (PA), frequência cardíaca (FC), percepção de esforço e parâmetros funcionais (fragilidade: teste de caminhada de 5 metros – T5M e capacidade funcional: teste de caminhada de 6 minutos – TC6) em momentos pré-TAVI, pós-TAVI (primeiro dia de pós-operatório) e na alta hospitalar. No pós-TAVI foi realizado protocolo de exercício físico com cicloergômetro de membros superiores em uma sessão com duas séries de cinco minutos. Resultados: Após o exercício, houve alteração (p=0,001) da PA sistólica (127,28±17,52 vs 138,36±19,20mmHg), FC (72,36±12,83 vs 81,13±17,92), Borg dispneia (0,62±1,17 vs 2,49±1,52) e Borg fadiga membros superiores (0,50±0,80 vs 3,08±1,49). O comportamento hemodinâmico ao exercício foi similar entre idosos e idosos longevos. A fragilidade e a capacidade funcional pioraram entre pré e pós-TAVI, mas melhoraram na alta hospitalar. Conclusão: O exercício com cicloergômetro foi seguro, viável e se mostrou benéfico na melhora da fragilidade e capacidade funcional para a alta hospitalar. Não houve registro de eventos adversos.

Introduction: Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) infection have been found to impact physical function significantly. However, data regarding the effect of TB/HIV co-infection on functional status remain limited. This study aimed to assess the impact of HIV co-infection on the functional independence and physical performance of TB patients during hospitalization, and associated mortality. Methods: This cross-sectional study included hospitalized TB patients from the Brazilian infectious diseases reference center. Their sociodemographic and clinical characteristics were recorded. Functional independence was assessed using the Functional Independence Measure (FIM), and physical performance was evaluated with the Short Physical Performance Battery (SPPB). Results: A total of 49 patients were included: 22 with TB/HIV co-infection and 27 with TB-only. The TB-only group showed significant increases in total FIM scores (p=0.027) and SPPB (p = 0.001) at discharge compared to admission, which was not observed in the TB/HIV co-infected group. Mortality occurred only in the TB/HIV co-infected group (p=0.01). Discussion: This study demonstrated that HIV co-infection impaired functional independence and physical performance in TB patients during hospitalization. This impairment was associated with poorer clinical outcomes, including elevated mortality, which aligns with previously documented HIV-related functional deficits. Our findings, which reveal higher mortality among co-infected individuals, are consistent with the widely recognized role of functional limitations in predicting poorer patient outcomes. Conclusion: The present study highlights the detrimental effect of HIV co-infection on both functional outcomes and survival in hospitalized TB patients. This underscores the urgent need for integrated care strategies to enhance functional outcomes and reduce mortality in this population.