Consider a person with total mental capacity and an active lifestyle who can now not communicate or connect with the world around them due to a severe motor impairment to being locked into their body. Assume the person cannot notify their caregiver when uncomfortable or in distress. Caregivers dealing with locked-in patients must currently rely on their instincts, troubleshooting skills, and standard operating procedures to offer the best care possible. And with these safeguards in place, patients continue to suffer from needless rashes, illnesses, and deaths that should have been avoided. Modern technologies could significantly change this outcome and are being under-utilized in such healthcare environments. This chapter explores patient behavioral analysis with smart healthcare and IoT.