Background. Nowadays, the immunomodulatory properties of plants have been studied extensively with greater interest due to increasing awareness and combating the severity of immunomodulatory diseases. Scope and Approach. This paper highlights the efficacy of the available literature evidence on natural immunomodulators of plant origin and synthetic ones. In addition, several aspects of plants and their phytoconstituents responsible for immunomodulation have been discussed. Moreover, this review also discusses the mechanism involved in immunomodulation. Key Findings. One hundred fifty medicinal immunomodulatory plants are currently identified to find novel immunomodulatory drugs. Of these plants, the plant family Asteraceae also takes the first rank by offering 18 plant species (12%). Similarly of the plants studied so far, 40% belong to the Asteraceae family. Echinacea purpurea of this family is most known for its immunostimulating activity. The most prominent immune‐active bioactive molecules are polyphenols, terpenoids, and alkaloids. Also, eight plant bioactive immunomodulators were checked for clinical trials and found in the market. These are six immunosuppressants, resveratrol, epigallocatechin‐3‐gallate, quercetin, colchicine, capsaicin, and andrographolide, and two immunostimulants, curcumin and genistein. Nowadays, there are a lot of polyherbal traditional medicinal products sold in the market and claimed to their immunomodulators. However, much work is still needed to find more active immunomodulatory agents. The mechanism by which immunomodulatory medicinal plant exert their effect is through the induction of cytokines and phagocyte cells and the inhibition of iNOS, PGE, and COX‐2 synthesis.

The medicinal benefits of P. lanceolata L. have been acknowledged worldwide for hundreds of years. The plant is now distributed worldwide, especially in temperate zones. This review gives an overview of ethnomedicinal use, phytochemistry, pharmacological activities, and other potential application of P. lanceolate L. Several effective chemical constituents such as polyphenols, tannins, flavonoids, alkaloids, terpenoids, iridoid glycosides, fatty acids, and polysaccharides are found in P. lanceolata L., which contribute to its exerting specific therapeutic effects. Correspondingly, studies have found that P. lanceolata L. has different biological activities, including antioxidant, antibacterial, wound-healing, anti-inflammatory, cytotoxic, and antiulcerogenic activity. The plant also treats various diseases related to the skin, respiratory organs, digestive organs, reproduction, circulation, cancer, pain relief, and infections. The plant has many applications in cosmetics such as lotion and creams; it is also used as an excellent indicator to know the presence and absence of heavy metals and the accumulation in industrial and urban areas. The plant suppresses soil nitrogen mineralization in agriculture due to allelochemicals such as aucubin. The biological activities, medicinal properties, and industrial application of P. lanceolata mainly depend on the activities of the responsible, active chemical constituents. However, this field still needs more study to determine the exact mechanisms and the main bioactive compound activity accountable for these activities. Also, most of the studies have been performed in vitro, so further in vivo studies are recommended for the future.

Biological synthesis of silver nanoparticles (AgNPs) is a green, simple, cost-effective, time-efficient, and single-step method. This study mainly focused on the synthesis of silver nanoparticles (AgNPs) using essential oil of Laggera tomentosa (LTEO) and investigates their potential applications. Ultraviolet-Visible (UV-Vis) result showed the characteristic Surface Plasmon Resonance (SPR) peak of LTEO-AgNPs at 420 nm. Fourier transform infrared (FT-IR) spectroscopy indicated the functional groups present in LTEO and LTEO-AgNPs. Scanning electron microscope (SEM) image depicted the synthesized AgNPs mainly has spherical shapes with average nanoparticles size 89.59 ± 5.14 nm. Energy dispersive X-ray (EDX) peak at 3.0 keV showed the presence of Ag element in LTEO-AgNPs. The X-ray diffraction (XRD) peaks at 38°, 44° and 67° are assigned to (111), (200), and (220), respectively which displays the crystal nature of LTEO-AgNPs. The average particle size and zeta potential of LTEO-AgNPs were determined as 94.98 nm and −49.6 mV, respectively. LTEO-AgNPs were stable for six months against aggregation at room temperature. LTEO-AgNPs solutions exhibited potential activities for the treatment of some pathogenic bacteria species, agricultural productivity growth, determination of metallic ions, and catalytic reduction. This study is the first work to report nanoparticles synthesis using L. tomentosa extracts and evaluate their potential applications.

Ethiopia is one of Africa’s six plant‐rich countries, with around 60% of the plants being indigenous and most of them having medicinal properties. 80% of people in the country use these plants as a primary health care system to tackle different diseases, including cancer. This review is aimed at summarizing the evidence gained from diverse MPs in Ethiopia that have been used ethnobotanically and ethnopharmacologically for treatment of cancer. The primary data sources were Google Scholar, Web of Science, Science Direct, Scopus, PubMed, and other electronic scientific databases. This literature review showed that there are around 200 MPs used as anticancer. Seventy‐four herbs, 39 trees, 77 shrubs, and 17 weed/climbers belonging to 56 families have been identified for their ethnobotanical anticancer potential, and 31 species were recognized for their pharmaceutically anticancer activities. The reviewed data also indicated that many Ethiopian MPs had been used to treat breast, lung, blood, and skin cancers and other tumors. Besides, the collected data showed that the leaves (36.76%), roots (27.2%), bark (12.5%), stem (5.1%), and fruit (7.35%) of plants are commonly used for the preparation of anticancer remedies. Among the reported plant species, Euphorbiaceae (10.71%), Acanthaceae (7.14%), and Asteraceae (7.1%) are the most prominent plant families being used to treat cancer ethnobotanically. Phytochemicals such as flavonoids (like xanthone, indirubin, flavopiridol, and silybin), alkaloids (like taxol, vincristine, evodiamine, and berberine), and physalin B, D, and F steroids exhibited anticancer activity on various cancer cell lines. The crude extracts of Aerva javanica, Vernonia leopoldi, Withania somnifera, Kniphofia foliosa, and Catharanthus roseus were powerful anticancer agents with an IC₅₀ value below 10 μg/mL. Although several Ethiopian plants possess anticancer potential, only a limited number of plants are scientifically studied. Therefore, more scientific studies on anticancer MPs should be carried out; it may lead to discovering and isolating cost‐effective and safe anticancer drugs.

Background: Rumex nepalensis, a widely known traditional medicinal plant and is used as the source of medicines and human diet in various communities. Currently, the phytochemical investigation and pharmacological studies ofR. nepalensisare of significant research interest. Therefore, the current review is mainly focused on the phytochemical investigation and pharmacological applications ofR. nepalensisMain body: Various secondary metabolites like emodin, endocrocin, chrysophanol, neopodin, physcion, torachrysone, aloesin, catechin, quercetin, resveratrol, and their derivatives were isolated from root and aerial parts of the plant. Both isolated compounds and extracts fromR. nepalensisare reported to have pharmacological activities such as anti-inflammatory, antioxidant, antimicrobial, wound healing, and anti-plasmodial activitiesConclusions: Different parts ofR. nepalensishave ethnomedicinal importance.R. nepalensisis one of the potential sources of pharmacologically active extracts and isolated compounds. In futureR. nepalensiscan play a vital role for the preparation of modern drugs.Graphical

Plants are the primary sources of cellulose. This paper is aimed at isolating cellulose from Oxytenanthera abyssinica via chemical treatments. The thermal behavior, functional group, chemical composition, crystallinity, and morphology of raw (ROA), dewaxed (DOA), alkali-treated (AOA), and bleached (BOA) fibers were examined. TGA, FTIR, DSC, DTA, XRD, and SEM were used for characterization techniques. The effects of chemical treatments were examined by determining the content of cellulose, hemicellulose, lignin, and ash. The cellulose content in the ROA improved from wt% to wt% due to the removal of noncellulose components using waxing, alkali treatment, and bleaching with alkali peroxide bleaching stages followed by aqueous chlorite in buffer solution. The highest content of cellulose and holocellulose was exhibited in the BOA samples with a yield of wt% and wt%, respectively. ROA had greater hemicellulose ( wt%), lignin ( wt%), and ash content ( wt%) in comparison to AOA and BOA. The XRD data showed a change in crystallinity after each treatment. Because of the high amount of crystalline cellulose, the XRD results revealed that BOA has a higher crystallinity index (CrI) (59.89%) and peak intensity than AOA, DOA, and ROA. The strength of the FTIR peaks increased in the order of ROA, DOA, AOA, and BOA, indicating that pretreatment causes hemicellulose and lignin to be gradually removed from the Oxytenanthera abyssinica fiber. The TGA, DTG, DTA, and DSC data also confirmed that BOA has the highest thermal stability due to the high content of cellulose. The SEM analysis showed a morphological change in the surface due to chemical treatment. These results confirmed that through chemical pretreatment, a high amount of cellulose was produced from Oxytenanthera abyssinica. Even though Oxytenanthera abyssinica is commonly grown in Ethiopia, few studies have been done on it, and no works have been carried out to isolate and characterize cellulose from the plant. Thus, the findings in this work will encourage researchers to use Oxytenanthera abyssinica as a source of cellulose for various applications, including the manufacture of cellulose nanocrystals, polymer matrix biofilters, green biocomposite reinforcing agents, and hydrogel synthesis.