Limenew Abate Worku Abate

Mr. Limenew Abate Worku Abate

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Research Focus & Metrics

Academic Career Length

5Years (2022-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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14 February 2023 in Membranes
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LALimenew Abate Worku Abate
Limenew Abate Worku Abate
ABArchana Bachheti
Archana Bachheti
Rakesh Kumar BachhetiRakesh Kumar Bachheti
Rakesh Kumar Bachheti
CRCristiano E.R. Reis
Cristiano E.R. Reis
Anuj Kumar ChandelAnuj Kumar Chandel
Anuj Kumar Chandel
The need for pulp and paper has risen significantly due to exponential population growth, industrialization, and urbanization. Most paper manufacturing industries use wood fibers to meet pulp and paper requirements. The shortage of fibrous wood resources and increased deforestation are linked to the excessive dependence on wood for pulp and paper production. Therefore, non-wood substitutes, including corn stalks, sugarcane bagasse, wheat, and rice straw, cotton stalks, and others, may greatly alleviate the shortage of raw materials used to make pulp and paper. Non-woody raw materials can be pulped easily using soda/soda-AQ (anthraquinone), organosolv, and bio-pulping. The use of agricultural residues can also play a pivotal role in the development of polymeric membranes separating different molecular weight cut-off molecules from a variety of feedstocks in industries. These membranes range in applications from water purification to medicinal uses. Considering that some farmers still burn agricultural residues on the fields, resulting in significant air pollution and health issues, the use of agricultural residues in paper manufacturing can eventually help these producers to get better financial outcomes from the grown crop. This paper reviews the current trends in the technological pitch of pulp and paper production from agricultural residues using different pulping methods, with an insight into the application of membranes developed from lignocellulosic materials.

4 July 2022 in Evidence-Based Complementary and Alternative Medicine
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Rakesh Kumar BachhetiRakesh Kumar Bachheti
Rakesh Kumar Bachheti
LALimenew Abate Worku Abate
Limenew Abate Worku Abate
YGYilma Hunde Gonfa
Yilma Hunde Gonfa
MZMeseret Zebeaman
Meseret Zebeaman
DEDeepti
Deepti
ABArchana Bachheti
Archana Bachheti
Cardiovascular diseases (CVDs) are the worlds leading killers, accounting for 30 deaths. According to the WHO report, CVDs kill 17.9 million people per year, and there will be 22.2 million deaths from CVD in 2030. The death rates rise as people get older. Regarding gender, the death rate of women by CVD (51) is higher than that of men (42). To decrease and prevent CVD, most people rely on traditional medicine originating from the plant (phytochemicals) in addition to or in preference to commercially available drugs to recover from their illness. The CVD therapy efficacy of 92 plants, including 15 terrestrial plants, is examined. Some medicinal plants well known to treat CVD are, Daucus carota, Nerium oleander, Amaranthus Viridis, Ginkgo biloba, Terminalia arjuna, Picrorhiza kurroa, Salvia miltiorrhiza, Tinospora cordifolia, Mucuna pruriens, Hydrocotyle asiatica, Bombax ceiba, and Andrographis paniculate. The active phytochemicals found in these plants are flavonoids, polyphenols, plant sterol, plant sulphur compounds, and terpenoids. A general flavonoid mechanism of action is to prevent low-density lipoprotein oxidation, which promotes vasodilatation. Plant sterols prevent CVD by decreasing cholesterol absorption in the blood. Plant sulphur compound also prevent CVD by activation of nuclear factor-erythroid factor 2-related factor 2 (Nrf2) and inhibition of cholesterol synthesis. Quinone decreases the risk of CVD by increasing ATP production in mitochondria while terpenoids by decreasing atherosclerotic lesion in the aortic valve. Although several physiologically active compounds with recognized biological effects have been found in various plants because of the increased prevalence of CVD, appropriate CVD prevention and treatment measures are required. More research is needed to understand the mechanism and specific plants phytochemicals responsible for treating CVD.

24 February 2025 in Scientific Reports
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AKArun Kumar Khajuria
Arun Kumar Khajuria
AKAnuj Kandwal
Anuj Kandwal
RSR. K. Sharma
R. K. Sharma
RBRakesh Kumar Bachheti
Rakesh Kumar Bachheti
LALimenew Abate Worku Abate
Limenew Abate Worku Abate
ABArchana Bachheti
Archana Bachheti
The preparation of metallic nanoparticles (NPs) using the green method is rapid, eco-friendly, and easily scaled up at room temperature and pressure. In the current study, zinc oxide nanoparticles (ZnO NPs) were prepared utilizing leaf extract from Mallotus philippinensis, employing two distinct precursors of zinc oxide: zinc acetate and zinc nitrate. The antioxidant and antibacterial properties of the synthesized nanoparticles were also evaluated. The synthesis of ZnO NPs was preliminary monitored by UV–visible analysis. The biosynthesized nanoparticles were further characterized using a variety of techniques, such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM), and ultraviolet-visible (UV-Vis) spectroscopy. XRD peaks showed that nanoparticles synthesized from both zinc precursors exhibit crystalline properties, having wurtzite hexagonal shapes. The TEM analysis indicates that the average crystallite size was determined to be 21 nm and 28 nm for zinc nitrate and zinc acetate as precursor. FTIR analysis confirmed the presence of polyphenolic compounds on the surface of the nanoparticles, which likely acted as reducing and capping agents during ZnO NP synthesis. The antioxidant activity of M. philippinensis-mediated ZnO NPs was assessed in vitro. ZnO NPs synthesized using zinc nitrate exhibited higher antioxidant potential (IC50 = 65.31 µg/ml) compared to those synthesized using zinc acetate (IC50 = 66.87 µg/ml). Furthermore, the ZnO NPs demonstrated significant antibacterial activity against both gram-positive and gram-negative bacteria, including Klebsiella pneumoniae (K. pneumoniae), Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), and Streptococcus pneumoniae (S. pneumoniae). The highest antibacterial activity was observed against S. pneumoniae, with a zone of inhibition of 14.97 ± 0.38 mm for ZnO NPs synthesized using zinc nitrate. These findings suggest that M. philippinensis leaf extract is an effective reducing and capping agent for the biosynthesis of ZnO NPs. The resulting nanoparticles exhibit potent antioxidant and antibacterial properties, highlighting their potential applications in biomedical and environmental fields.

27 March 2022 in Journal of Chemistry
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LALimenew Abate Worku Abate
Limenew Abate Worku Abate
Rakesh Kumar BachhetiRakesh Kumar Bachheti
Rakesh Kumar Bachheti
MTMesfin Getachew Tadesse
Mesfin Getachew Tadesse
ABArchana Bachheti
Archana Bachheti
The medicinal benefits of P. lanceolata L. have been acknowledged worldwide for hundreds of years. The plant is now distributed worldwide, especially in temperate zones. This review gives an overview of ethnomedicinal use, phytochemistry, pharmacological activities, and other potential application of P. lanceolate L. Several effective chemical constituents such as polyphenols, tannins, flavonoids, alkaloids, terpenoids, iridoid glycosides, fatty acids, and polysaccharides are found in P. lanceolata L., which contribute to its exerting specific therapeutic effects. Correspondingly, studies have found that P. lanceolata L. has different biological activities, including antioxidant, antibacterial, wound-healing, anti-inflammatory, cytotoxic, and antiulcerogenic activity. The plant also treats various diseases related to the skin, respiratory organs, digestive organs, reproduction, circulation, cancer, pain relief, and infections. The plant has many applications in cosmetics such as lotion and creams; it is also used as an excellent indicator to know the presence and absence of heavy metals and the accumulation in industrial and urban areas. The plant suppresses soil nitrogen mineralization in agriculture due to allelochemicals such as aucubin. The biological activities, medicinal properties, and industrial application of P. lanceolata mainly depend on the activities of the responsible, active chemical constituents. However, this field still needs more study to determine the exact mechanisms and the main bioactive compound activity accountable for these activities. Also, most of the studies have been performed in vitro, so further in vivo studies are recommended for the future.

1 January 2022 in BioMed Research International
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LALimenew Abate Worku Abate
Limenew Abate Worku Abate
MTMesfin Getachew Tadesse
Mesfin Getachew Tadesse
ABArchana Bachheti
Archana Bachheti
Rakesh Kumar BachhetiRakesh Kumar Bachheti
Rakesh Kumar Bachheti
Ethiopia is one of Africa’s six plant‐rich countries, with around 60% of the plants being indigenous and most of them having medicinal properties. 80% of people in the country use these plants as a primary health care system to tackle different diseases, including cancer. This review is aimed at summarizing the evidence gained from diverse MPs in Ethiopia that have been used ethnobotanically and ethnopharmacologically for treatment of cancer. The primary data sources were Google Scholar, Web of Science, Science Direct, Scopus, PubMed, and other electronic scientific databases. This literature review showed that there are around 200 MPs used as anticancer. Seventy‐four herbs, 39 trees, 77 shrubs, and 17 weed/climbers belonging to 56 families have been identified for their ethnobotanical anticancer potential, and 31 species were recognized for their pharmaceutically anticancer activities. The reviewed data also indicated that many Ethiopian MPs had been used to treat breast, lung, blood, and skin cancers and other tumors. Besides, the collected data showed that the leaves (36.76%), roots (27.2%), bark (12.5%), stem (5.1%), and fruit (7.35%) of plants are commonly used for the preparation of anticancer remedies. Among the reported plant species, Euphorbiaceae (10.71%), Acanthaceae (7.14%), and Asteraceae (7.1%) are the most prominent plant families being used to treat cancer ethnobotanically. Phytochemicals such as flavonoids (like xanthone, indirubin, flavopiridol, and silybin), alkaloids (like taxol, vincristine, evodiamine, and berberine), and physalin B, D, and F steroids exhibited anticancer activity on various cancer cell lines. The crude extracts of Aerva javanica, Vernonia leopoldi, Withania somnifera, Kniphofia foliosa, and Catharanthus roseus were powerful anticancer agents with an IC50 value below 10 μg/mL. Although several Ethiopian plants possess anticancer potential, only a limited number of plants are scientifically studied. Therefore, more scientific studies on anticancer MPs should be carried out; it may lead to discovering and isolating cost‐effective and safe anticancer drugs.

1 July 2022 in South African Journal of Botany
Verified
Journal Article
Open access
ABArchana Bachheti
Archana Bachheti
RBRakesh Kumar Bachheti
Rakesh Kumar Bachheti
LALimenew Abate Worku Abate
Limenew Abate Worku Abate
AHAzamal Husen
Azamal Husen