Cardiovascular disease (CVD) is a life-threatening disease rising considerably in the world. Early detection and prediction of CVD as well as other heart diseases might protect many lives. This requires tact clinical data analysis. The potential of predictive machine learning algorithms to develop the doctor’s perception is essential to all stakeholders in the health sector since it can augment the efforts of doctors to have a healthier climate for patient diagnosis and treatment. We used the machine learning (ML) algorithm to carry out a significant explanation for accurate prediction and decision making for CVD patients. Simple random sampling was used to select heart disease patients from the Khyber Teaching Hospital and Lady Reading Hospital, Pakistan. ML methods such as decision tree (DT), random forest (RF), logistic regression (LR), Naïve Bayes (NB), and support vector machine (SVM) were implemented for classification and prediction purposes for CVD patients in Pakistan. We performed exploratory analysis and experimental output analysis for all algorithms. We also estimated the confusion matrix and recursive operating characteristic curve for all algorithms. The performance of the proposed ML algorithm was estimated using numerous conditions to recognize the best suitable machine learning algorithm in the class of models. The RF algorithm had the highest accuracy of prediction, sensitivity, and recursive operative characteristic curve of 85.01%, 92.11%, and 87.73%, respectively, for CVD. It also had the least specificity and misclassification errors of 43.48% and 8.70%, respectively, for CVD. These results indicated that the RF algorithm is the most appropriate algorithm for CVD classification and prediction. Our proposed model can be implemented in all settings worldwide in the health sector for disease classification and prediction.

Bitcoin (BTC-USD) is a virtual currency that has grown in popularity after its inception in 2008. BTC-USD is an internet communication network that makes using digital money, including digital payments, easy. It offers decentralized clearing of transactions and money supply. This study attempts to accurately anticipate the BTC-USD prices (Close) using data from September 2023 to September 2024, comprising 390 observations. Four machine learning models—Multi-layer Perceptron, Extreme Learning Machine, Neural Network AutoRegression, and Extreme-Gradient Boost—as well as four time series models—Auto-Regressive Integrated Moving Average, Auto-Regressive, Non-Parametric Auto-Regressive, and Simple Exponential Smoothing models—are used to achieve this end. Various hybrid models are then proposed utilizing these models, which are based on simple averaging of these models. The data-splitting technique, commonly used in comparative analysis, splits the data into training and testing data sets. Through comparison testing with training data sets consisting of 30%, 20%, and 10%, the present work demonstrated that the suggested hybrid model outperforms the individual approaches in terms of error metrics, such as the MAE, RMSE, MAPE, SMAPE, and direction accuracy, such as correlation and the MDA of BTC. Furthermore, the DM test is utilized in this study to measure the differences in model performance, and a graphical evaluation of the models is also provided. The practical implication of this study is that financial analysts have a tool (the proposed model) that can yield insightful information about potential investments.

Bio-informatics and gene expression analysis face major hurdles when dealing with high-dimensional data, where the number of variables or genes much outweighs the number of samples. These difficulties are exacerbated, particularly in microarray data processing, by redundant genes that do not significantly contribute to the response variable. To address this issue, gene selection emerges as a feasible method for identifying the most important genes, hence reducing the generalization error of classification algorithms. This paper introduces a new hybrid approach for gene selection by combining the Signal-to-Noise Ratio (SNR) score with the robust Mood median test. The Mood median test is beneficial for reducing the impact of outliers in non-normal or skewed data since it may successfully identify genes with significant changes across groups. The SNR score measures the significance of a gene's classification by comparing the gap between class means and within-class variability. By integrating both of these approaches, the suggested approach aims to find genes that are significant for classification tasks. The major objective of this study is to evaluate the effectiveness of this combination approach in choosing the optimal genes. A significant P-value is consistently identified for each gene using the Mood median test and the SNR score. By dividing the SNR value of each gene by its significant P-value, the Md score is calculated. Genes with a high signal-to-noise ratio (SNR) have been considered favorable due to their minimal noise influence and significant classification importance. To verify the effectiveness of the selected genes, the study utilizes two dependable classification techniques: Random Forest and K-Nearest Neighbors (KNN). These algorithms were chosen due to their track record of successfully completing categorization-related tasks. The performance of the selected genes is evaluated using two metrics: error reduction and classification accuracy. These metrics offer an in-depth assessment of how well the selected genes improve classification accuracy and consistency. According to the findings, the hybrid approach put out here outperforms conventional gene selection methods in high-dimensional datasets and has lower classification error rates. There are considerable improvements in classification accuracy and error reduction when specific genes are exposed to the Random Forest and KNN classifiers. The outcomes demonstrate how this hybrid technique might be a helpful tool to improve gene selection processes in bioinformatics.

Background of study: Over the past few decades, the utilization of Artificial Intelligence (AI) has surged in popularity, and its application in the medical field is witnessing a global increase. Nevertheless, the implementation of AI-based healthcare solutions has been slow in developing nations like Pakistan. This unique study aims to assess the opinion of clinical specialists on the future replacement of AI, its associated benefits, and its drawbacks in form southern region of Pakistan. Material and methods: A cross-sectional selective study was conducted from 140 clinical specialists (Surgery = 24, Pathology = 31, Radiology = 35, Gynecology = 35, Pediatric = 17) from the neglected southern Punjab region of Pakistan. The study was analyzed using χ² - the test of association and the nexus between different factors was examined by multinomial logistic regression. Results: Out of 140 respondents, 34 (24.3%) believed hospitals were ready for AI, while 81 (57.9%) disagreed. Additionally, 42(30.0%) were concerned about privacy violations, and 70(50%) feared AI could lead to unemployment. Specialists with less than 6 years of experience are more likely to embrace AI (p = 0.0327, OR = 3.184, 95% C.I; 0.262, 3.556) and those who firmly believe that AI knowledge will not replace their future tasks exhibit a lower likelihood of accepting AI (p = 0.015, OR = 0.235, 95% C.I: (0.073, 0.758). Clinical specialists who perceive AI as a technology that encompasses both drawbacks and benefits demonstrated a higher likelihood of accepting its adoption (p = 0.084, OR = 2.969, 95% C.I; 0.865, 5.187). Conclusion: Clinical specialists have embraced AI as the future of the medical field while acknowledging concerns about privacy and unemployment.

Cardiovascular disease (CVD) is a leading cause of death and disability worldwide, and its incidence and prevalence are increasing in many countries. Modeling of CVD plays a crucial role in understanding the trend of CVD death cases, evaluating the effectiveness of interventions, and predicting future disease trends. This study aims to investigate the modeling and forecasting of CVD mortality, specifically in the Sindh province of Pakistan. The civil hospital in the Nawabshah area of Sindh province, Pakistan, provided the data set used in this study. It is a time series dataset with actual cardiovascular disease (CVD) mortality cases from 1999 to 2021 included. This study analyzes and forecasts the CVD deaths in the Sindh province of Pakistan using classical time series models, including Naïve, Holt-Winters, and Simple Exponential Smoothing (SES), which have been adopted and compared with a machine learning approach called the Artificial Neural Network Auto-Regressive (ANNAR) model. The performance of both the classical time series models and the ANNAR model has been evaluated using key performance indicators such as Root Mean Square Deviation Error, Mean Absolute Error (MAE), and Mean Absolute Percentage Error (MAPE). After comparing the results, it was found that the ANNAR model outperformed all the selected models, demonstrating its effectiveness in predicting CVD mortality and quantifying future disease burden in the Sindh province of Pakistan. The study concludes that the ANNAR model is the best-selected model among the competing models for predicting CVD mortality in the Sindh province. This model provides valuable insights into the impact of interventions aimed at reducing CVD and can assist in formulating health policies and allocating economic resources. By accurately forecasting CVD mortality, policymakers can make informed decisions to address this public health issue effectively.

Particulate matter with a diameter of 2.5 microns or less (PM2.5) is a significant type of air pollution that affects human health due to its ability to persist in the atmosphere and penetrate the respiratory system. Accurate forecasting of particulate matter is crucial for the healthcare sector of any country. To achieve this, in the current work, a new time series ensemble approach is proposed based on various linear (autoregressive, simple exponential smoothing, autoregressive moving average, and theta) and nonlinear (nonparametric autoregressive and neural network autoregressive) models. Three ensemble models are also developed, each employing distinct weighting strategies: equal distribution of weight among all single models (ESME), weight assignment based on training average accuracy errors (ESMT), and weight assignment based on validation mean accuracy measures (ESMV). This technique was applied to daily PM2.5 concentration data from 1 January 2019, to 31 May 2023, in Pakistan’s main cities, including Lahore, Karachi, Peshawar, and Islamabad, to forecast short-term PM2.5 concentrations. When compared to other models, the best ensemble model (ESMV) demonstrated mean errors ranging from 3.60% to 25.79% in Islamabad, 0.81%–13.52% in Lahore, 1.08%–7.06% in Karachi, and 1.09%–12.11% in Peshawar. These results indicate that the proposed ensemble approach is more efficient and accurate for short-term PM2.5 forecasting than existing models. Furthermore, using the best ensemble model, a forecast was made for the next 15 days (June 1 to 15 June 2023). The forecast showed that in Lahore, the highest PM2.5 value (236.00 μg/m3) was observed on 8 June 2023. Other days also displayed higher and poor air quality throughout the 15 days. Conversely, Karachi experienced moderate PM2.5 concentration levels between 50 μg/m3 and 80 μg/m3. In Peshawar, the PM2.5 concentration levels were consistently unhealthy, with the highest peak (153.00 μg/m3) observed on 9 June 2023. This forecasting experience can assist environmental monitoring organizations in implementing cost-effective planning to minimize air pollution.