Lung cancer is the leading cause of cancer-related mortality worldwide, primarily driven by genetic mutations. The most common genetic alterations implicated in lung cancer include mutations in TP53, KRAS, KEAP1, NF1, EGFR, NRF2, ATM, ALK, Rb1, BRAF, MET, and ERBB2. Targeted therapies have been developed to inhibit cancer growth by focusing on these specific genetic mutations. However, either the mutations are undruggable or the efficacy of these therapies is often compromised over time due to the emergence of drug resistance, which can occur through additional mutations in the targeted protein or alternative growth signaling pathways. In recent years, immunotherapy has emerged as a promising approach to enhance the effectiveness of cancer treatment by leveraging the body’s immune system. Notable advancements include immune checkpoint inhibitors, monoclonal antibodies targeting cell surface receptors, antibody–drug conjugates, and bispecific antibodies. This review provides an overview of the mechanisms of FDA-approved immunotherapeutic drugs, offering an updated perspective on the current state and future developments in lung cancer therapy. More importantly, the factors that positively and negatively impact the immunotherapy’s efficacy will also be discussed.

Chinese medicinal herbs (CMHs) have been used for thousands of years because of their significant properties regarding the prevention and treatment of diseases, such as COVID-19. There is an increasingly diminishing supply of wild medicinal resources, and the demand is greater than the supply. Ecological balance and the conservation of natural Chinese medicinal herbs are serious issues in sustainable development, which requires the minimum requirements to be met without compromising the resources of future generations, especially with respect to the maintenance of production and consumption as well as the quality control of CMHs. Hong Kong is an urban business city, busy with work and the fast pace of life. The sustainable development of CMHs is difficult in a huge population situated in an area with very scarce land coverage. The conservation of CMHs in urban horticulture is extremely neglected because people lack living space; for example, Aquilaria Sinensis (the incense tree), also called “pak muk heung” in Cantonese, was an indigenous species that was illegally logged in the past. This led to detrimental effects on the population density and genetic diversity of the species. There is no doubt that Hong Kong is required to set up a management model in community facilities for these emerging modern social configurations, such as building a Chinese herbal garden for the conservation and promotion of a healthy urban environment and giving people a chance to gain more information on CMHs. The current study employed problem analysis and strategic decisions for the sustainable development of 62 kinds of CMHs in a Chinese herbal garden, which converged with some medicinal itineraries of Lingnan herbal medications, and implemented a theoretical framework of management models for ten secondary schools, e.g., the Aroma garden of the L’Occitane at the Technological and Higher Education Institute of Hong Kong (THEi) Tsing Yi campus and Land from the Far East Consortium International Limited in Sai Kung Pak Kong. In the present original article, we would like to establish a sustainable management model for Chinese herbal gardens in an urban city. The sustainable development model for the Chinese herbal gardens is based on five major aspects: (1) land resources, (2) manpower planning, (3) economy, (4) education or training, and (5) ecosystem (cultivation). These are the essential factors of management and are implemented in our Chinese herbal gardens. We aim to find a suitable management model for Chinese herbal gardens and to promote it in other urban cities.

Eczema is the most common skin disease among Hong Kong’s adults and children, affecting an estimated 30% of the total population. Western and Chinese medicinal ointments are the usual treatment for eczema. Conventional Western medicinal ointments are topical corticosteroids and non-steroidal agents. Eczema skin products include “Aveeno Parabens Lotion”, “Cerave Moisturizing Cream”, and “Cetaphil Lotion”. However, these are not a long-term solution for managing significant erythema. Chinese medicinal ointments are based on adjusting the formula, including the ingredients and amount, to address an individual’s skin condition and other factors that may be worsening symptoms. This approach aims to regulate the immune system and make it less reactive to environmental and food allergies. This approach is mainly for local topical use. The ingredients of eczema skin products should include Coptis chinensis Franch, Phellodendron chinense Schneid, Angelica sinensis (Oliv.) Diels, Rehmannia glutinosa Libosch, Curcuma longa L., and sesame oil. Chinese medicinal ointments are natural ingredients, personalized formulas, and concerned with holistic healing, while Western medicinal ointments provide fast-acting relief, targeted action, and a standardized dosage. Methods: Nine electronic databases, such as WanFang Data, PubMed, Science Direct, Scopus, Web of Science, Springer Link, SciFinder, and the China National Knowledge Infrastructure (CNKI), were searched mainly within the past twenty years and without any language restrictions. The inclusion criteria were the keywords “Western medicine and ointment”, “Chinese medicine and ointment”, and “Western and Chinese medicines and ointment”. Differences in effectiveness between Western and Chinese ointments were evaluated to determine if they had functions against eczema. This review included an analysis and summary of all relevant papers. Results: Western medicinal ointments are topical corticosteroids, and they exert their pharmacological activities via many mechanisms, including anti-inflammatory, immunosuppressive, antiproliferative, and vasoconstrictive effects on eczema. Similarly, Chinese medicinal ointments have the same pharmacological functions, but they may focus on the immune system for the treatment of inflammatory and skin conditions, including erythema, edema, dryness, desquamation, and callus exfoliation. Conclusion: Based on the clinical research, the effectiveness rate of integrated Chinese and Western medicines was 88%, which was greater than the 70% rate for using Western medicine alone to treat eczema. Western and Chinese medicinal ointments have different active ingredients with advantages and disadvantages for eczema or when acting as skin care products. The most important thing is knowing “How” to use Western and Chinese medicinal ointments properly, especially for some formulations of Chinese ointments. It may be beneficial to consider the pharmacokinetic studies of herbal ingredients, which offer personalized formulas tailored to individual body constitutions and conditions, as well as to emphasize holistic healing, addressing both symptoms and underlying imbalances in the body. Much more work needs to be carried out, such as safety assessments of these ointments for use as skin care products for eczema.

The coronavirus disease 2019 (COVID‐19) pandemic occurred in Hong Kong for more than two years. This article conducted a cross‐sectional study for participants to investigate the behavioral prevention, treatment, and rehabilitation of using Western medicines or herbal products for COVID‐19 in Hong Kong. A questionnaire was designed and performed over 2 weeks from 1 May to 15 May 2022. It consisted of five parts with around 20 questions conducted including sociodemographic information, prevention, treatment, rehabilitation of COVID‐19, and also the sources of information. The pattern usage of Chinese or Western medicines for COVID‐19 was studied after data collection. 318 people participated in this survey, and only 311 were qualified. The sociodemographic information, e.g., personal educational level, and behavior for the prevention of COVID‐19, which included wearing masks (98.7%), using alcohol hand sanitizer (83.0%), washing hands frequently (82.4%), avoiding crowds (53.1%), and staying home more often (50.6%). Western medicines, such as antipyretic drugs, antitussive drugs, and pain reliever drugs, whilst Chinese medicines, such as Lianhua Qingwen Jiaonang, Huoxiang Zhengqi San or Wan, and Nin Jiom Pei Pa Koa, were most commonly used in the treatment and rehabilitation periods of COVID‐19. Herbal products, including lemon, honey, ginger, and herbal tea, were used as a daily diet to fight against COVID‐19. Based on the result findings, Chinese medicines or herbal products were used during the COVID‐19 pandemic, but most of the participants used an unknown Chinese medicine practitioner’s prescription and self‐administered Chinese medicine. The pattern of Chinese medicines and Western medicines’ usage in the prevention, treatment, and rehabilitation of COVID‐19 was also investigated; this showed a statistically significant association between the variables according to gender, age, and Chinese or Western medicines for further investigation.